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Thermogenic mechanisms in brown fat.
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“UCP1 plays a role in adaptive thermogenesis in mammalian brown adipose tissue to produce heat (314), whereas the actions of UCP2 and 3 are upregulated in response to oxidant stress caused by nutrient deprivation, glucose sensing, fatty acid metabolism, or other metabolic changes in order to lessen mitochondrial ROS production (49).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [314]
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Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Role of ROS and RNS Sources in Physiological and Pathological Conditions
Meo, S. D., Reed, T. T., Venditti, P., & Víctor, V. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1245049 · Cited by 1,712
“However, whether in tissues differently from BAT UCP1 homologues are responsible for mitochondrial basal or inducible proton conductance is yet controversial [280].”
Background
Metadata
- Authors
- Nicholls, D. G., & Locke, R. M.
- ORCID
- Nicholls, D G
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1984-01
- Volume
- 64
- Issue
- 1
- Pages
- 1-64
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1900866157
- Cited by
- 1,602
- References
- 0
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 24 · 2023: 21 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 34 · 2018: 40 · 2017: 36 · 2016: 45 · 2015: 35 · 2014: 42 · 2013: 38 · 2012: 34
- FWCI
- 44.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipose tissue, thermogenesis, non-shivering thermogenesis, UCP1, mitochondrial respiration, energy expenditure
- MeSH terms
- Adaptation, Physiological, Cyclic AMP, Adenosine Triphosphate, Animals, Biomechanical Phenomena, Body Temperature Regulation, Adipose Tissue, Brown, Carrier Proteins, Cyclic AMP Receptor Protein, Cell Physiological Phenomena, Central Nervous System, Chlorides, Cytosol, Diet, Fatty Acids, Cricetinae, Hibernation, Hydrogen-Ion Concentration, Insulin, Lipolysis, Mitochondria, Obesity, Oxidation-Reduction, Permeability, Protein Kinases, Proteins, Protons, Receptors, Adrenergic, beta, Respiratory Physiological Phenomena, Sympathetic Nervous System, Thyroid Hormones, Time Factors, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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