Cited by 1,602Adipose Tissue and MetabolismLipid metabolism and biosynthesisPeroxisome Proliferator-Activated Receptors

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Thermogenic mechanisms in brown fat.

Nicholls, D G, Locke, R M·1984·Physiological Reviews

DOI 10.1152/physrev.1984.64.1.1

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Background
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Background
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Background
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Background
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Background
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Intrinsic and extrinsic uncoupling of oxidative phosphorylation
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Rinaldo, P., Matern, D., & Bennett, M. J. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.082201.154705 · Cited by 483
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Background
Developmental programming of obesity in mammals
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Background
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de Jesus, L. A., Carvalho, S. D., Ribeiro, M. O., Schneider, M. J., Kim, S.-W., Harney, J. W., Larsen, P. R., & Bianco, A. C. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113803 · Cited by 537
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Brookes, P. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.016 · Cited by 447
Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion
Chavin, K. D., Yang, S., Lin, H. Z., Chatham, J. C., Chacko, V. P., Hoek, J. B., Walajtys-Rode, E., Rashid, A., Chen, C., Huang, C., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5692 · Cited by 443
The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism
Halestrap, A. P. (1989) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(89)80378-0 · Cited by 440
Differential Expression of Peroxisome Proliferator-Activated Receptor- , - , and - during Rat Embryonic Development
Braissant, O., & Wahli, W. (1998) · Endocrinology · doi:10.1210/endo.139.6.6049 · Cited by 457
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Background
The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues
Mráček, T., Drahota, Z., & Houštěk, J. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.11.014 · Cited by 438
“Cytosolic ATP production in BAT is important despite the high rate of fatty acid oxidation as mitochondria contain only tiny amount of ATP synthase [50,51] and all energy generated by OXPHOS is released by the action of uncoupling protein (UCP1) as heat [52].”
The efficiency and plasticity of mitochondrial energy transduction.
Brand, M. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330897 · Cited by 406
Thyroid hormones and their effects: a new perspective
Hulbert, A. J. (2000) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s146479310000556x · Cited by 436
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Gong, D., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Chou, C. J., Everett, C. A., Kozak, L. P., Li, C., Deng, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910177199 · Cited by 382
White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis
Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 390
“This phenomenon is primarily mediated by UCP 1 (Ucp1), which is a specific BAT marker (Nicholls and Locke, 1984).”
Background
Thyroid Hormone Control of Thermogenesis and Energy Balance
Silva, J. E. (1995) · Thyroid · doi:10.1089/thy.1995.5.481 · Cited by 392
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Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance
Ricquier, D., & Bouillaud, F. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00003.x · Cited by 392
“Cold-induced thermogenesis in rodents has long been known to involve brown adipose tissue and a mitochondrial uncoupling protein (UCP) (Girardier, 1983; Nicholls & Locke, 1984; Cannon & Nedergaard, 1985; Himms-Hagen & Ricquier, 1998).”
BackgroundInfluential
Mitochondrial uncoupling proteins in the cns: in support of function and survival
Andrews, Z. B., Diano, S., & Horváth, T. L. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1767 · Cited by 374
Effect of fatty acids on energy coupling processes in mitochondria
Wojtczak, L., & Schönfeld, P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90004-y · Cited by 363
Structure and function of the uncoupling protein from brown adipose tissue
Klingenberg, M., & Huang, S. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00232-6 · Cited by 359
Pten positively regulates brown adipose function, energy expenditure, and longevity
Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gómez-López, G., Cañamero, M., Mulero, F., Pastor, J., Martinez, S., Romanos, E., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.001 · Cited by 356
“Energy dissipation in brown adipocytes is mediated by the uncoupling protein Ucp1 (Nicholls and Locke, 1984).”
Background
Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity
Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 353
“mice, rats, Syrian (Mesocricetus auratus) and Djungarian (Phodopus sungorus) hamsters (24).”
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Chan, C. B., De Leo, D., Joseph, J. W., McQuaid, T. S., Ha, X. F., Xu, F., Tsushima, R. G., Pennefather, P. S., Salapatek, A. M. F., & Wheeler, M. B. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1302 · Cited by 341
“UCP-2 shares homology with UCP-1 (2), a moiety known to dissipate the mitochondrial membrane potential (Cm) and uncouple oxidative respiration (4).”
Background
Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent
Matthias, A., Ohlson, K. B. E., Fredriksson, J. M., Jacobsson, A., Nedergaard, J., & Cannon, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000547200 · Cited by 343
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Dyar, K. A., Lutter, D., Artati, A., Ceglia, N., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.042 · Cited by 345
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Background
The Fuzzy Logic of Physiological Cardiac Hypertrophy
Dorn, G. W. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.079426 · Cited by 328
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Garlid, K., Orosz, D. E., Modrianský, M., Vassanelli, S., & Ježek, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2615 · Cited by 327
Coenzyme Q is an obligatory cofactor for uncoupling protein function
Echtay, K. S., Winkler, E., & Klingenberg, M. (2000) · Nature · doi:10.1038/35046114 · Cited by 334
“(1) The reconstituted IB-UCP1 may not attain the full native con®guration.”
BackgroundResult
Brown adipose tissue thermogenesis and obesity
Himms‐Hagen, J. (1989) · Progress in Lipid Research · doi:10.1016/0163-7827(89)90009-x · Cited by 324
Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
Jabůrek, M., Vařecha, M., Gimeno, R. E., Dembski, M., Ježek, P., Zhang, M., Burn, P., Tartaglia, L. A., & Garlid, K. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26003 · Cited by 321
Brown Adipose Tissue Energy Metabolism in Humans
Carpentier, A. C., Blondin, D. P., Virtanen, K. A., Richard, D., Haman, F., & Turcotte, É. E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00447 · Cited by 338
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Background
Uncoupling proteins 2 and 3 are highly active H + transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
Echtay, K. S., Winkler, E., Frischmuth, K., & Klingenberg, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1416 · Cited by 313
Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice
Surwit, R. S., Wang, S., Petro, A. E., Sanchı́s, D., Raimbault, S., Ricquier, D., & Collins, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4061 · Cited by 311
Implications of nonshivering thermogenesis for energy balance regulation in humans
Lichtenbelt, W. D. V. M., & Schrauwen, P. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00652.2010 · Cited by 318
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Sanchı́s, D., Fleury, C., Chomiki, N., Goubern, M., Huang, Q., Neverova, M., Gregoire, F. M., Easlick, J. L., Raimbault, S., Lévi-Meyrueis, C., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34611 · Cited by 310
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Pearen, M. A., & Muscat, G. E. O. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0015 · Cited by 308
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Mancini, M., Anderson, B. O., Caldwell, E., Sedghinasab, M., Paty, P. B., & Hockenbery, D. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.2.449 · Cited by 305
“There is precedent for the activation or upregulation of specific agents of mitochondrial dysfunction in the mitochondrial uncoupling protein present in brown fat adipocytes (80).”
Background
Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression
Jacobsson, A., Stadler, U., Glotzer, M. A., & Kozak, L. P. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36228-2 · Cited by 300
Slow TCA flux and ATP production in primary solid tumours but not metastases
Bartman, C. R., Weilandt, D. R., Shen, Y., Lee, W. D., Han, Y., TeSlaa, T., Jankowski, C. S. R., Samarah, L., Park, N. R., da Silva-Diz, V., et al. (2023) · Nature · doi:10.1038/s41586-022-05661-6 · Cited by 299
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Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., & Samad, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91014.2008 · Cited by 295
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Background
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Guan, Y., & Breyer, M. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00766.x · Cited by 292
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Flier, J. S. (1995) · Cell · doi:10.1016/0092-8674(95)90445-x · Cited by 290
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Trayhurn, P., Duncan, J. S., & Rayner, D. V. (1995) · Biochemical Journal · doi:10.1042/bj3110729 · Cited by 291
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
Almind, K., Manieri, M., Sivitz, W. I., Cinti, S., & Kahn, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610416104 · Cited by 286
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Xue, B., Rim, J.-S., Hogan, J. C., Coulter, A. A., Koza, R. A., & Kozak, L. P. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600287-jlr200 · Cited by 288
“Heat generated through the uncoupling of oxidative phosphorylation via uncoupling protein 1 (UCP1) in brown adipose tissue maintains body temperature in small and newborn mammals exposed to cold (6, 7).”
Background
The uncoupling protein ucp: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue
Klaus, S., Casteilla, L., Bouillaud, F., & Ricquier, D. (1991) · International Journal of Biochemistry · doi:10.1016/0020-711x(91)90062-r · Cited by 286
Brown adipose tissue: physiological function and evolutionary significance
Oelkrug, R., Polymeropoulos, E. T., & Jastroch, M. (2015) · Journal of Comparative Physiology B · doi:10.1007/s00360-015-0907-7 · Cited by 297
“It is broadly accepted that BAT is the major source of adaptive NST in modern eutherian mammals (Nicholls and Locke 1984; Cannon and Nedergaard 2004).”
Background
Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315737 · Cited by 281
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Yang, Y. T., & McElligott, M. A. (1989) · Biochemical Journal · doi:10.1042/bj2610001 · Cited by 274
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The effects of Xanthigen ™ in the weight management of obese premenopausal women with non‐alcoholic fatty liver disease and normal liver fat
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“• Induction of the mitochondrial uncoupling protein 1 (UCP1) [13], which leads to an increased resting energy expenditure (REE) by uncoupling a step during cellular metabolism [14].”
Background
The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases
Lee, J. H., Park, A., Oh, K., Lee, S. C., Kim, W. K., & Bae, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194924 · Cited by 280
“They focused on the elevation of mitochondrial ROS during BAT thermogenesis and established that thermogenic ROS alters the redox status of cysteine thiols in BAT to drive increased respiration and that Cys-253 of UCP1 is a key target [78,79].”
BackgroundInfluential
Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.
Rogler, C. E., Yang, D., Rossetti, L., Donohoe, J. M., Alt, E., Chang, C., Rosenfeld, R. G., Neely, K., & Hintz, R. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36715-7 · Cited by 272
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“UCP-1 or thermogenin was discovered in brown adipose tissue where it serves as a proton leak to uncouple electron transport from ATP synthesis and hence in thermoregulation in newborns and hibernating animals (Matthias et al., 1999; Nedergard and Cannon, 1992; Nicholls and Locke, 1984; Nicholls and Rial, 1999; Silva a…”
Background
Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure
Carrière, A., Jeanson, Y., Berger-Müller, S., André, M., Chenouard, V., Arnaud, E., Barreau, C., Walther, R., Galinier, A., Wdziekonski, B., et al. (2014) · Diabetes · doi:10.2337/db13-1885 · Cited by 277
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Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
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“By expecting UCP1-deficient mice to have increased susceptibility to obesity, we have failed to appreciate that brown fat in the mouse and rat is extraordinarily efficient at generating heat (25, 26).”
Background
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells
Kiyonaka, S., Kajimoto, T., Sakaguchi, R., Shinmi, D., Omatsu‐Kanbe, M., Matsuura, H., Imamura, H., Yoshizaki, T., Hamachi, I., Morii, T., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2690 · Cited by 263
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“In the brown adipose tissue, mitochondrial uncoupling is mediated by uncoupling protein 1 (UCP1) and serves non-shivering thermogenesis.(41) UCP1 is an H+ translocase, which channels protons from the intermembrane space back into the matrix space, thereby bypassing the F0F1-ATPase, reducing ATP production with the gen…”
Background

Authors: Nicholls, D. G., & Locke, R. M.
ORCID: Nicholls, D G
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 1984-01
Volume: 64
Issue: 1
Pages: 1-64
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.1984.64.1.1
OpenAlex: W1900866157
Cited by: 1,602
References: 0
Citations by year: 2026: 10 · 2025: 14 · 2024: 24 · 2023: 21 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 34 · 2018: 40 · 2017: 36 · 2016: 45 · 2015: 35 · 2014: 42 · 2013: 38 · 2012: 34
FWCI: 44.71
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: brown adipose tissue, thermogenesis, non-shivering thermogenesis, UCP1, mitochondrial respiration, energy expenditure
MeSH terms: Adaptation, Physiological, Cyclic AMP, Adenosine Triphosphate, Animals, Biomechanical Phenomena, Body Temperature Regulation, Adipose Tissue, Brown, Carrier Proteins, Cyclic AMP Receptor Protein, Cell Physiological Phenomena, Central Nervous System, Chlorides, Cytosol, Diet, Fatty Acids, Cricetinae, Hibernation, Hydrogen-Ion Concentration, Insulin, Lipolysis, Mitochondria, Obesity, Oxidation-Reduction, Permeability, Protein Kinases, Proteins, Protons, Receptors, Adrenergic, beta, Respiratory Physiological Phenomena, Sympathetic Nervous System, Thyroid Hormones, Time Factors, Mice, Rats

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