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Synaptic vesicle biogenesis, docking, and fusion: a molecular description
Abstract
Secretion of neurotransmitter is the primary means of intercellular communication within the nervous system. This process is regulated by a highly orchestrated cycle of membrane trafficking within the presynaptic nerve terminal. Characterization of proteins localized to the synaptic vesicle and the subsequent studies of their properties have led to a model for the biochemical pathway that underlies vesicle docking, activation, and fusion. The proteins found to function in the synapse are related to those in yeast and other organisms, demonstrating that the mechanisms that mediate vesicle trafficking are conserved in all eukaryotic species.
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Citations
Cited by
DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Somogyi, P., Tamás, G., Lujan, R., & Buhl, E. H. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00061-1 · Cited by 872
Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release
Reim, K., Mansour, M., Varoqueaux, F., McMahon, H. T., Südhof, T. C., Brose, N., & Rosenmund, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00192-1 · Cited by 499
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Matsuura, Y., Iwanaga, T., et al. (2000) · Nature Cell Biology · doi:10.1038/35041046 · Cited by 481
Metadata
- Authors
- Calakos, N., & Scheller, R. H.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1996-01-01
- Volume
- 76
- Issue
- 1
- Pages
- 1-29
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2172586216
- Cited by
- 348
- References
- 0
- FWCI
- 21.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Calakos, N., & Scheller, R. H. (1996). Synaptic vesicle biogenesis, docking, and fusion: a molecular description. Physiological Reviews. https://doi.org/10.1152/physrev.1996.76.1.1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.