Antibiotic Susceptibilities of Helicobacter pylori Strains Isolated in the Province of Alberta
Open accessAbstract
The incidence of antibiotic resistance to amoxicillin, clarithromycin, erythromycin, metronidazole and tetracycline in Helicobacter pylori strains isolated from gastric biopsy specimens obtained in Alberta was investigated. Results for all antibiotics were obtained using agar dilution, and in addition to metronidazole, the E test was used. Resistance to amoxicillin and tetracycline was not detected. Metronidazole resistance determined using agar dilution was approximately 12% (95% CI 4% to 26%) when minimal inhibitory concentrations (MICs) were at least 8 µg/mL, but fell to 2% (95% CI 0.1% to 13%) when MICs were set at 32 µg/mL or greater. The E test for metronidazole resistance (MIC 8 µg/mL or greater) yielded a slightly higher percentage of resistant strains compared with agar dilution tests (14%, 95% CI 5% to 29%). One of the 31 strains was resistant to clarithromycin (MIC 8 µg/mL) and erythromycin (MIC 16 µg/mL). Thus, the incidence of resistance to clarithromycin, part of the currently used triple therapy for eradication of H pylori, was 3% (95% CI 0.1% to 17%).
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MICs of tetracycline for susceptible H. pylori strains are usually between 0.125 and 0.5 μg/ml.
“MICs of tetracycline for susceptible H. pylori strains are usually between 0.125 and 0.5 μg/ml (33), and the MIC for strain 26695 is 0.5 μg/ml (Table 2).”
From Mutations in the 16S rRNA Genes of<i>Helicobacter pylori</i>Mediate Resistance to Tetracycline (2002) · cites this paper as [33]
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Mutations in the 16S rRNA Genes of<i>Helicobacter pylori</i>Mediate Resistance to Tetracycline
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- Authors
- Taylor, D. E., Jiang, Q., & Fedorak, R. N.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Taylor, Diane E
- Venue
- Canadian Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 12
- Issue
- 4
- Pages
- 295-298
- ISSN
- 2291-2789 (ISSN-L)
- 2291-2797
- OpenAlex
- W2332875228
- Cited by
- 25
- References
- 25
- Citations by year
- 2019: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Canadian Journal of Gastroenterology and Hepatology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Terry Fox Run
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- Helicobacter pylori, antibiotic resistance, metronidazole resistance, clarithromycin resistance, erythromycin resistance, amoxicillin, tetracycline, triple therapy, eradication therapy, minimum inhibitory concentration, Alberta
- MeSH terms
- Alberta, Anti-Bacterial Agents, Drug Resistance, Microbial, Humans, Microbial Sensitivity Tests, Helicobacter pylori, Helicobacter Infections
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