Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice
Open accessAbstract
We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil dietary administered at three concentrations (0.4% thyme and 0.2% oregano oils; 0.2% thyme and 0.1% oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis. Treatment of colitic animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines IL-1β, IL-6, GM-CSF, and TNFα, especially after application of the medium dose. The medium dose of the essential oils significantly lowered the amount of IL-1βand IL-6 proteins too. Moreover, administration of the medium dose decreased the mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic damage of the colonic tissue. Our results indicate that combined treatment with appropriate concentrations of thyme and oregano essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate TNBS-induced colitis in mice.
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The inhibitory effect of some essential oils on pro-inflammatory cytokine production seems to be mediated by suppressing gene expression of these cytokines, mainly at the transcriptional level.
“The inhibitory effect of some of the essential oils on the production of pro-inflammatory cytokines reported in this chapter seems to be mediated by suppressing gene expression of these cytokines. Such was described by some authors because they found that the essential oils studied significantly suppressed the protein and mRNA expression of the cytokines in stimulated cells, assuming therefore,”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [124]
Some combinations of thyme and oregano oils lower amounts of IL-1β and IL-6 cytokines in mice with TNBS-induced colitis.
“The anti-inflammatory effects of diverse combination of thyme (p-cymene and thymol as main components) and oregano (carvacrol as major component) oils on mice with TNBS-induced colitis showed that some combinations lowered the amounts of IL-1β and IL-6 cytokines [124].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [124]
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References 47 · Cited by 125
Research works printed but not linked: 2
- [16]Brasseur T Etudes botaniques, phytochimiques et pharmacologiques consacrées au thym Journal de Pharmacie de Belgique 1983 38 5 261 272 6668539
- [34]Juhás Š Čikoš Š Czikková S Effects of borneol and thymoquinone on TNBS induced colitis in mice submitted to Folia Biologica. 18226358
- Authors
- Bukovská, A., Cikoš, Š., Juhás, Š., Il’ková, G., Rehák, P., & Koppel, J.
- Affiliations
- Slovak Academy of Sciences (SK)
- Corresponding author
- Koppel, Juraj
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2007
- Volume
- 2007
- Pages
- 1-9
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC2233768
- OpenAlex
- W2042655248
- Cited by
- 125
- References
- 47
- Citations by year
- 2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 10 · 2015: 2 · 2014: 7 · 2013: 8 · 2012: 2
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Slovak Research and Development Agency (APVT-51-015404)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- thyme essential oil, oregano essential oil, TNBS-induced colitis, inflammatory bowel disease, anti-inflammatory activity, inflammatory cytokines, IL-1β, interleukin-6, TNF-α, GM-CSF, mortality
- MeSH terms
- Animals, Body Weight, Colitis, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Inflammation, Male, Mice, Inbred BALB C, Oils, Volatile, Trinitrobenzenesulfonic Acid, Interleukin-6, Origanum, Thymus Plant, Mice, Interleukin-1beta
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