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Mass Spectrometry-Based Label-Free Quantitative Proteomics
Open accessAbstract
In order to study the differential protein expression in complex biological samples, strategies for rapid, highly reproducible and accurate quantification are necessary. Isotope labeling and fluorescent labeling techniques have been widely used in quantitative proteomics research. However, researchers are increasingly turning to label-free shotgun proteomics techniques for faster, cleaner, and simpler results. Mass spectrometry-based label-free quantitative proteomics falls into two general categories. In the first are the measurements of changes in chromatographic ion intensity such as peptide peak areas or peak heights. The second is based on the spectral counting of identified proteins. In this paper, we will discuss the technologies of these label-free quantitative methods, statistics, available computational software, and their applications in complex proteomics studies.
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Cites
Mass spectrometry-based proteomics
Aebersold, R., & Mann, M. (2003) · Nature · doi:10.1038/nature01511 · Cited by 6,955
Lu, P., Vogel, C., Wang, R., Yao, X., & Marcotte, E. M. (2007) · Nature Biotechnology · doi:10.1038/nbt1270 · Cited by 1,139
Cited by
Wang, H., Alvarez, S., & Hicks, L. M. (2012) · Journal of Proteome Research · doi:10.1021/pr2008225 · Cited by 142
Wei, Y.-N., Hu, H.-Y., Xie, G.-C., Fu, N., Ning, Z.-B., Zeng, R., & Khaitovich, P. (2015) · Genome Biology · doi:10.1186/s13059-015-0608-2 · Cited by 117
Wu, Q., Yuan, H., Zhang, L., & Zhang, Y. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.04.010 · Cited by 94
Metadata
- Authors
- Zhu, W., Smith, J. W., & Huang, C.-M.
- Venue
- Journal of Biomedicine and Biotechnology
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-6
- ISSN
- 1110-7243 (ISSN-L)
- 1110-7251
- OpenAlex
- W2014032285
- Cited by
- 629
- References
- 2
- FWCI
- 15.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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