The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Early-Life Origins of Type 2 Diabetes: Fetal Programming of the Beta-Cell Mass
Open accessAbstract
A substantial body of evidence suggests that an abnormal intrauterine milieu elicited by maternal metabolic disturbances as diverse as undernutrition, placental insufficiency, diabetes or obesity, may program susceptibility in the fetus to later develop chronic degenerative diseases, such as obesity, hypertension, cardiovascular diseases and diabetes. This paper examines the developmental programming of glucose intolerance/diabetes by disturbed intrauterine metabolic condition experimentally obtained in various rodent models of maternal protein restriction, caloric restriction, overnutrition or diabetes, with a focus on the alteration of the developing beta-cell mass. In most of the cases, whatever the type of initial maternal metabolic stress, the beta-cell adaptive growth which normally occurs during gestation, does not take place in the pregnant offspring and this results in the development of gestational diabetes. Therefore gestational diabetes turns to be the ultimate insult targeting the offspring beta-cell mass and propagates diabetes risk to the next generation again. The aetiology and the transmission of spontaneous diabetes as encountered in the GK/Par rat model of type 2 diabetes, are discussed in such a perspective. This review also discusses the non-genomic mechanisms involved in the installation of the programmed effect as well as in its intergenerational transmission.
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“These individuals are more likely to have experienced hyperglycemia and β-cell fatigue even before birth, predisposing them to hyperglycemia during times of later metabolic stress, such as during pregnancy [55].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [55]
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Cites
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
(2000) · PubMed · Cited by 13,173
Obesity : Preventing and managing the global epidemic
Akram, D. S., Astrup, A. V., Atinmo, T., Boissin, J.-L., Bray, G. A., Carroll, K. N., Chitson, P., Chen, C., Dietz, W. H., Hill, J. O., et al. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 12,945
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016
Fetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327
Flagged first, then by citations
Research works printed but not linked: 14
- 1995, American Journal of Human Genetics, 57, 160
- 1981, Diabetologia, 20, 540
- 1989, American Journal of Obstetrics and Gynecology, 160, 1091
- 1990, Diabetes/Metabolism Reviews, 16, 147
- 1990, Adult offspring from mildly hyperglycemic rats show impairment of glucose regulation and insulin secretion which is transmissible to the next generation, 555
- 2008, Diabetologia, 51, 151A
- 1997, American Journal of Physiology, 272, E634
- 1991, Diabetes, 40, 115
- 1996, American Journal of Physiology, 270, E559
- 10.1210/en.138.6.2267 · DOI
- 2007, American Journal of Physiology—Regulatory Integrative and Comparative Physiology, 292, E187
- 10.1172/JCI200421845 · DOI
- 2001, American Journal of Physiology—Regulatory Integrative and Comparative Physiology, 281, E592
- 2009, Trends in Endocrinology and Metabolism, 21, 223
Cited by
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Items 101–127 of 127
Using data on biomarkers and siblings to study early‐life economic determinants of type‐2 diabetes
Alessie, R. J. M., Angelini, V., van den Berg, G. J., Mierau, J. O., & Niccodemi, G. (2024) · Health Economics · doi:10.1002/hec.4815 · Cited by 1
CCKergic System, Hypothalamus-Pituitary-Adrenal (HPA) Axis, and Early-Life Stress (ELS)
Tang, M., Joseph, A. M., Chen, Q., Jiao, J., & Tang, Y. (2012) · InTech eBooks · doi:10.5772/52042 · Cited by 1
Pregestational Diabetes Mellitus
Norwitz, E. R., Saade, G. R., Miller, H. S., & Davidson, C. M. (2016) · Wiley eBooks · doi:10.1002/9781118849897.ch13 · Cited by 1
Lu, Y., Jjang, Z., Jia, Y., Liu, J., Xu, Y., Wu, Q., & Chen, K. (2020) · doi:10.21203/rs.3.rs-78696/v1 · Cited by 1
High-Fat Programming of β-Cell Dysfunction
Cerf, M. E. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_3-6
Bacani, J. G. (2013) · YorkSpace (York University)
Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation
Tran, K. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/e746-pp32
Romero, A., & Gabriela, M. (2012) · USFQ Digital Repository (Universidad San Francisco de Quito)
Association birth weight overweight and hypertension in adolescents
Arrocha, M. F., Fernández, J. E., Rodríguez, B., Martínez, A., Martínez, R. C., Pérez, H., Assef, & de Investigaciones, C. (2015) · Revista Habanera de Ciencias Médicas
Early Screening of Gestational Diabetes Mellitus
Mahdavian, M. (2015) · Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)
Nishimura, H., Yaoita, E., Nameta, M., Yamaguchi, K., Sato, M., Ihoriya, C., Zhao, L., Kawachi, H., Sasaki, T., Ikezumi, Y., et al. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174416000787
Origine développementale des maladies métaboliques : l’empreinte du père
Portha, B., Grandjean, V., Maouche, K., & Movassat, J. (2018) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2018.07.004
Self-citationComputational Analysis of Pyocyanin (Phz Gene) From Pseudomonas
Rathan, S., & Sundararaman, G. (2020) · Scholars Journal of Applied Medical Sciences · doi:10.36347/sjams.2020.v08i09.028
Skills, Early-Life Environment and Health in Adulthood
Niccodemi, G. (2022) · doi:10.33612/diss.194511989
Aydos, D., Aksoy, Z. B., Ünal, M. A., Akçalı, K. C., Bitirim, C. V., & Turan, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.09.648025
Roy, I., Sultana, N., Hasan, M., Mahmood, T., Shayedat-Ullah, M., & Hasan, M. R. (2025) · Cureus · doi:10.7759/cureus.85562
Fisher, R. E. (2013) · The Atrium (University of Guelph)
Ilchmann-Diounou, H. (2019) · theses.fr (ABES) · doi:10.70675/77d1e895zc1e7z4ff0zab27z0432cc19c25d · Cited by 1
Le réseau de cellules hypophysaires thyréotropes
Kemkem, Y. (2020) · theses.fr (ABES) · doi:10.70675/90549cc3z54daz42adza2a0zb29b72c265ee
Delangre, E. (2021) · theses.fr (ABES) · doi:10.70675/622d48edz59dcz427ez85c9z9da5f8129e84
Metabolic environment and epigenetic programming of the early embryo in rabbit
y Rada, R. V. (2022) · theses.fr (ABES) · doi:10.70675/536319d0z3a53z4da0z808cz9ab1c3f5ac7a
Dino, K. Ó., Santos, P. H. L. D., Klann, T. V., Felix, C. B., & Lopes, G. F. A. (2026) · Revista de Geopolítica · doi:10.56238/revgeov17n5-056
Oh, T. K., & Song, I. (2026) · Nutrients · doi:10.3390/nu18152406
Ahmadasadi, H., Emamgholi, P. R., Layali, I., Kianfar, T., Tork, S., Jafarpour, M., Aliabadi, M., & Heydari, H. (2026) · PLoS ONE · doi:10.1371/journal.pone.0354870
Solihah, I., Garmana, A. N., Happyana, N., & İnsanu, M. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119951
Metadata
- Authors
- Portha, B., Chavey, A., & Movassat, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Portha, Bernard
- ORCID
- Movassat, Jamileh
- Venue
- Experimental Diabetes Research
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-16
- ISSN
- 1687-5214 (ISSN-L)
- 1687-5303
- PMC
- PMC3202114
- OpenAlex
- W2154337610
- Cited by
- 127
- References
- 147
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 14
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Experimental Diabetes Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- French National Research Agency (ANR-06-PHYSIO-028)
- Égide (ANR-06-PHYSIO-028)
- NEB Association (ANR-06-PHYSIO-028)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- type 2 diabetes, fetal programming, beta-cell mass, maternal protein restriction, caloric restriction, maternal overnutrition, maternal diabetes, gestational diabetes mellitus, impaired glucose tolerance, intergenerational transmission, developmental programming
- MeSH terms
- Animals, Energy Intake, Diabetes Mellitus, Type 2, Disease Models, Animal, Female, Humans, Male, Pancreas, Pregnancy, Pregnancy in Diabetics, Prenatal Exposure Delayed Effects, Protein Deficiency, Risk Factors, Diabetes, Gestational, Overnutrition, Fetal Development, Insulin-Secreting Cells, Mice, Rats
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