Successful Treatment of Chronic Mucocutaneous Candidiasis Caused by Azole-Resistant Candida albicans with Posaconazole
Open accessAbstract
Refractory or recurrent infections of skin, nails, and the mucous membranes are clinical signs of chronic mucocutaneous candidiasis, frequently associated with immunological defects. Here we describe a 39-years-old female patient, with familial CMC, that presented with an extensive infection caused by an azole-resistant Candida albicans isolate, successfully treated with posaconazole.
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Posaconazole effectively treated infections resistant to first-line azoles in A. fumigatus, C. albicans, and C. neoformans.
“One of the newest azoles, posaconazole (POS), effectively treated infections resistant to first-line azoles in A. fumigatus, C. albicans, and C. neoformans (Chau et al. 2004; Xiao et al. 2004; Firinu et al. 2011; Sionov et al. 2012).”
From Acquisition of cross-azole tolerance and aneuploidy in <i>Candida albicans</i> strains evolved to posaconazole (2022) · cites this paper as Firinu et al. 2011
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- Authors
- Firinu, D., Massidda, O., Lorrai, M. M., Serusi, L., Peralta, M., Barca, M. P., Serra, P., & Manconi, P. E.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Firinu, Davide
- Venue
- Clinical and Developmental Immunology
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-4
- ISSN
- 1740-2522 (ISSN-L)
- 1740-2530
- PMC
- PMC3003968
- OpenAlex
- W1987908342
- Cited by
- 23
- References
- 21
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical and Developmental Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- chronic mucocutaneous candidiasis, Candida albicans, azole resistance, posaconazole, antifungal therapy, immunodeficiency
- MeSH terms
- Administration, Oral, Adult, Antifungal Agents, Candida albicans, Candidiasis, Chronic Mucocutaneous, Female, Humans, Triazoles, Treatment Outcome, Drug Resistance, Fungal
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