Cited by 13Renal Diseases and GlomerulopathiesRenal and related cancersChronic Kidney Disease and Diabetes

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Relevance of VEGF and Nephrin Expression in Glomerular Diseases

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Bertuccio, Claudia A.·2011·Journal of Signal Transduction

DOI 10.1155/2011/718609PMC PMC3144718

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Abstract

The glomerular filtration barrier is affected in a large number of acquired and inherited diseases resulting in extensive leakage of plasma albumin and larger proteins, leading to nephrotic syndrome and end-stage renal disease. Unfortunately, the molecular mechanisms governing the development of the nephrotic syndrome remain poorly understood. Here, I give an overview of recent investigations that have focused on characterizing the interrelationships between the slit diaphragm components and podocytes-secreted VEGF, which have a significant role for maintaining the normal podocyte structure and the integrity of the filtering barrier.

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See all 13

Authors: Bertuccio, C. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Bertuccio, Claudia A.
Venue: Journal of Signal Transduction
Publisher: Hindawi Limited
Published: 2011-07-26
Volume: 2011
Pages: 1-9
ISSN: 2090-1739 (ISSN-L)
2090-1747
DOI: 10.1155/2011/718609
PMC: PMC3144718
OpenAlex: W2080899474
Cited by: 12
References: 133
Citations by year: 2025: 1 · 2024: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2014: 2 · 2012: 1
FWCI: 0.74
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Journal of Signal Transduction (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
Health Sciences › Medicine › Oncology › Renal and related cancers
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: vascular endothelial growth factor, nephrin, glomerular disease, nephrotic syndrome, slit diaphragm, podocytes, glomerular filtration barrier, proteinuria, end-stage renal disease

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Relevance of VEGF and Nephrin Expression in Glomerular Diseases

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