Combined Venlafaxine and Olanzapine Prescription in Women with Psychotic Major Depression: A Case Series
Open accessAbstract
Patients with psychotic major depression suffer prolonged duration and greater severity of illness, including an increased likelihood of recurrent episodes and resistance to conventional pharmacotherapies. They do not respond to placebo and respond poorly to antidepressant or antipsychotic monotherapy. On the other hand, as has been demonstrated, they do respond well to antidepressant and antipsychotic combination therapies. Different combinations of drugs were studied, but little is known up to now with regard to the combination of venlafaxine and olanzapine. The following paper presents three separate case studies of female patients suffering from psychotic unipolar major depression, all of whom were admitted to a psychiatric ward and successfully treated with a combination of venlafaxine and olanzapine.
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In a PTSD model induced by single prolonged stress, decreased glutathione reductase in the amygdala significantly elevated when grape powder treatment was applied.
“employing a model of PTSD induced by a single prolonged stress, it was noticed that the decreased levels of glutathione reductase found in the amygdala significantly elevated when grape powder treatment was applied.”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [174]
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Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“Also, when grape powder was given before the inducing of PTSDmodel, it was observed that raises in oxidative rates and inflammation were prevented, as proven, for example, by the analysis of plasma 8-isoprostane levels [174].”
- Authors
- Ghio, L., Natta, W., Rossi, P., Peruzzo, L., Zanelli, E., Gotelli, S., & Gabrielli, F.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Ghio, Lucio
- Venue
- Case Reports in Medicine
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-4
- ISSN
- 1687-9627 (ISSN-L)
- 1687-9635
- PMC
- PMC3087461
- OpenAlex
- W2015262019
- Cited by
- 6
- References
- 20
- Citations by year
- 2022: 2 · 2017: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Case Reports in Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- psychotic depression, venlafaxine, olanzapine, women, treatment-resistant depression, major depressive disorder
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