The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?
Open accessAbstract
One of the main features of the immune response to M. Tuberculosis is the formation of an organized structure called granuloma. It consists mainly in the recruitment at the infectious stage of macrophages, highly differentiated cells such as multinucleated giant cells, epithelioid cells and Foamy cells, all these cells being surrounded by a rim of lymphocytes. Although in the first instance the granuloma acts to constrain the infection, some bacilli can actually survive inside these structures for a long time in a dormant state. For some reasons, which are still unclear, the bacilli will reactivate in 10% of the latently infected individuals, escape the granuloma and spread throughout the body, thus giving rise to clinical disease, and are finally disseminated throughout the environment. In this review we examine the process leading to the formation of the granulomatous structures and the different cell types that have been shown to be part of this inflammatory reaction. We also discuss the different in vivo and in vitro models available to study this fascinating immune structure.
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Cites
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
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Foamy macrophages and the progression of the human tuberculosis granuloma
Russell, D. G., Cardona, P.-J., Kim, M.-J., Allain, S., & Altare, F. (2009) · Nature Immunology · doi:10.1038/ni.1781 · Cited by 827
Self-citationHuman Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
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Self-citationTuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates
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DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
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Cited by
The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells
Dartois, V. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3200 · Cited by 388
Mateos-Hernández, L., Risco-Castillo, V., Torres-Maravilla, E., Bermúdez-Humarán, L. G., Alberdi, P., Hodžić, A., Hernández-Jarguin, A., Rakotobe, S., Galon, C., Devillers, E., et al. (2020) · Vaccines · doi:10.3390/vaccines8020285 · Cited by 46
Metadata
- Authors
- Silva Miranda, M., Breiman, A., Allain, S., Deknuydt, F., & Altare, F.
- Venue
- Clinical and Developmental Immunology
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-14
- ISSN
- 1740-2522 (ISSN-L)
- 1740-2530
- OpenAlex
- W2071527192
- Cited by
- 318
- References
- 113
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Silva Miranda, M., Breiman, A., Allain, S., Deknuydt, F., & Altare, F. (2012). The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria? Clinical and Developmental Immunology. https://doi.org/10.1155/2012/139127
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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