Alternative activation of macrophages: mechanism and functions

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Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation

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T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

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Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells

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CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock

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mTOR differentially regulates effector and regulatory T cell lineage commitment

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Macrophage Polarization Comes of Age

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Dectin-1: a signalling non-TLR pattern-recognition receptor

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Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences

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IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis

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Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response

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Pulmonary fibrosis: pathogenesis, etiology and regulation

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Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

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Chitin induces accumulation in tissue of innate immune cells associated with allergy

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IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasionPreprint

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Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

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IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

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Alternative Macrophage Activation Is Essential for Survival during Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology

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Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism

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Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

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Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB

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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

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FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

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Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

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The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

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IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

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Control of Macrophage Activation and Function by PPARs

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Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

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Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites

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Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

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Epigenetic regulation of the alternatively activated macrophage phenotype

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The phenotype of murine wound macrophages

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Asthma and Allergic Inflammation

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Folate Receptor β Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

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Alternative activation of macrophages: immune function and cellular biology

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Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system

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The IL-21 receptor augments Th2 effector function and alternative macrophage activation

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The Macrophage Mannose Receptor Induces IL-17 in Response to Candida albicans

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Fundamental Immunology

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Molecular mediators of macrophage fusion

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IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype

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Interleukin‐13 alters the activation state of murine macrophages in vitro: Comparison with interleukin‐4 and interferon‐γ

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IL4Rα+ Myeloid-Derived Suppressor Cell Expansion in Cancer Patients

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SHIP Represses the Generation of Alternatively Activated Macrophages

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Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

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Dynamics of macrophage polarization reveal new mechanism to inhibit IL‐1β release through pyrophosphates

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Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response

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A Two-Step Process for Cytokine Production Revealed by IL-4 Dual-Reporter Mice

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Features of the dendritic cell lineage

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Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity

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Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4-, and IFN-β-dependent

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Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis

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Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion

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Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain

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Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

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Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

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IL-13 Signaling via IL-13Rα2 Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis

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Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10.

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IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL

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Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13Rα2

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IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin

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Chronic Helminth Infection Induces Alternatively Activated Macrophages Expressing High Levels of CCR5 with Low Interleukin-12 Production and Th2-Biasing Ability

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Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity

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Interleukin-13 Protects Against Experimental Autoimmune Myocarditis by Regulating Macrophage Differentiation

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Innate Immune Responses to Lung-Stage Helminth Infection Induce Alternatively Activated Alveolar Macrophages

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Francisella tularensis Live Vaccine Strain Induces Macrophage Alternative Activation as a Survival Mechanism

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Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1β System by IL-13

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Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4

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