Cited by 624Renin-Angiotensin System StudiesCoagulation, Bradykinin, Polyphosphates, and AngioedemaEicosanoids and Hypertension Pharmacology

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Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease

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Tikellis, Chris, Thomas, M. C.·2012·International Journal of Peptides

DOI 10.1155/2012/256294PMC PMC3321295

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Abstract

Angiotensin-converting enzyme 2 (ACE2) shares some homology with angiotensin-converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the degradation of Ang II resulting in the formation of angiotensin 1–7 (Ang 1–7) which opposes the actions of Ang II. Increased Ang II levels are thought to upregulate ACE2 activity, and in ACE2 deficient mice Ang II levels are approximately double that of wild-type mice, whilst Ang 1–7 levels are almost undetectable. Thus, ACE2 plays a crucial role in the RAS because it opposes the actions of Ang II. Consequently, it has a beneficial role in many diseases such as hypertension, diabetes, and cardiovascular disease where its expression is decreased. Not surprisingly, current therapeutic strategies for ACE2 involve augmenting its expression using ACE2 adenoviruses, recombinant ACE2 or compounds in these diseases thereby affording some organ protection.

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See all 624

Authors: Tikellis, C., & Thomas, M. C.
Affiliations: Baker Heart and Diabetes Institute (AU)
Corresponding author: Tikellis, Chris
ORCID: Thomas, M. C.
Venue: International Journal of Peptides
Publisher: Hindawi Limited
Published: 2012-03-20
Volume: 2012
Pages: 1-8
ISSN: 1687-9767 (ISSN-L)
1687-9775
DOI: 10.1155/2012/256294
PMC: PMC3321295
OpenAlex: W2082133861
Cited by: 624
References: 85
Citations by year: 2026: 8 · 2025: 11 · 2024: 31 · 2023: 57 · 2022: 87 · 2021: 164 · 2020: 244 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3
FWCI: 1.65
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: International Journal of Peptides (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders: National Health and Medical Research Council
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: angiotensin-converting enzyme 2, renin-angiotensin system, angiotensin II, angiotensin-(1-7), hypertension, diabetes mellitus, cardiovascular disease, organ protection

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Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease

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