COVID-19 and cardiovascular disease
Abstract
Coronavirus disease 2019 (COVID-19) is a global pandemic affecting 185 countries and >3 000 000 patients worldwide as of April 28, 2020. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2, which invades cells through the angiotensin-converting enzyme 2 receptor. Among patients with COVID-19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury from the infection (22% of critically ill patients). Although angiotensin-converting enzyme 2 serves as the portal for infection, the role of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers requires further investigation. COVID-19 poses a challenge for heart transplantation, affecting donor selection, immunosuppression, and posttransplant management. There are a number of promising therapies under active investigation to treat and prevent COVID-19.
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Aging, obesity and inflammation-related diseases such as diabetes and cardiovascular diseases are risk factors for the severity of COVID-19.
“Of note, aging, obesity and inflammation-related diseases such as diabetes and cardiovascular diseases have been shown to be risk factors for the severity of COVID-19 (293, 371–373).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [373]
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- Authors
- Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., Jain, S. S., Burkhoff, D., Kumaraiah, D., Rabbani, L., Schwartz, A., & Uriel, N.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- ORCID
- Venue
- Circulation
- Published
- 2020-05-19
- Volume
- 141
- Issue
- 20
- Pages
- 1648-1655
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W3012454642
- Cited by
- 1,738
- References
- 7
- Citations by year
- 2026: 30 · 2025: 46 · 2024: 105 · 2023: 168 · 2022: 291 · 2021: 509 · 2020: 587
- FWCI
- 18.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Oncology › COVID-19 and healthcare impacts
- Keywords
- COVID-19 pandemic, SARS-CoV-2, cardiovascular disease, myocardial injury, ACE2 receptor, ACE inhibitors, angiotensin receptor blockers, heart transplantation, donor selection, immunosuppression, COVID-19 treatment
- MeSH terms
- Betacoronavirus, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Angiotensin-Converting Enzyme Inhibitors, Cardiovascular Diseases, Humans, Peptidyl-Dipeptidase A, Pneumonia, Viral, Receptors, Virus, Coronavirus Infections, Angiotensin Receptor Antagonists, Pandemics
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