The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
Structure and Pathology of Tau Protein in Alzheimer Disease
Open accessAbstract
Alzheimer's disease (AD) is the most common type of dementia. In connection with the global trend of prolonging human life and the increasing number of elderly in the population, the AD becomes one of the most serious health and socioeconomic problems of the present. Tau protein promotes assembly and stabilizes microtubules, which contributes to the proper function of neuron. Alterations in the amount or the structure of tau protein can affect its role as a stabilizer of microtubules as well as some of the processes in which it is implicated. The molecular mechanisms governing tau aggregation are mainly represented by several posttranslational modifications that alter its structure and conformational state. Hence, abnormal phosphorylation and truncation of tau protein have gained attention as key mechanisms that become tau protein in a pathological entity. Evidences about the clinicopathological significance of phosphorylated and truncated tau have been documented during the progression of AD as well as their capacity to exert cytotoxicity when expressed in cell and animal models. This paper describes the normal structure and function of tau protein and its major alterations during its pathological aggregation in AD.
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Cited by
Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
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Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases
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Role of tau protein in Alzheimer’s disease: The prime pathological player
Muralidar, S., Ambi, S. V., Sekaran, S., Thirumalai, D., & Palaniappan, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.327 · Cited by 278
Tau immunotherapy for Alzheimer's disease
Pedersen, J. T., & Sigurdsson, E. M. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.03.003 · Cited by 247
Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus
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Metadata
- Authors
- Kolarova, M., García-Sierra, F., Bartos, A., Ricny, J., & Ripova, D.
- Venue
- International Journal of Alzheimer's Disease
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-13
- ISSN
- 2090-0252 (ISSN-L)
- 2090-8024
- OpenAlex
- W1972493045
- Cited by
- 468
- References
- 168
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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