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Inhibitory Activities of Cudrania tricuspidata Leaves on Pancreatic Lipase In Vitro and Lipolysis In Vivo
Open accessAbstract
To identify effective herb to treat obesity, we screened 115 herbal extracts for inhibition of porcine pancreatic lipase (triacylg-ycerol acylhydrolase, EC 3.1.1.3) activity in vitro . Of the extracts tested, Cudrania tricuspidata leaves exhibited the most pronounced inhibitory effect on lipase activity with an IC 50 value of 9.91 μ g/mL. Antilipid absorption effects of C. tricuspidata leaves were examined in rats after oral administration of lipid emulsions containing 50 or 250 mg C. tricuspidata /kg body weight. Plasma triacylglycerol levels 2 h after the oral administration of emulsions containing C. tricuspidata were significantly reduced compared to the untreated group ( P < 0.05 ). These results suggest that C. tricuspidata leaves may be useful for the treatment of obesity.
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“Previous reports have shown that lipase inhibitors can effectively reduce fat absorption to suppress weight gain in obese patients [13,18].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [18]
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Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose
Zhang, R., Chen, J., Mao, X., Qi, P., & Zhang, X. (2019) · Molecules · doi:10.3390/molecules24193527 · Cited by 34
Metadata
- Authors
- Kim, Y. S., Lee, Y., Kim, J., Sohn, E., Kim, C. S., Lee, Y. M., Jo, K., Shin, S., Song, Y., Kim, J. H., & Kim, J. S.
- Affiliations
- Korea Institute of Oriental Medicine (KR)
- Gachon University (KR)
- Corresponding author
- Kim, Jin Sook
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-8
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC3529879
- OpenAlex
- W1988664047
- Cited by
- 37
- References
- 25
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 6 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 2
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Korea Institute of Oriental Medicine (K11040, K12040)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Keywords
- Cudrania tricuspidata, leaves, pancreatic lipase inhibition, lipolysis, obesity, plant extracts, plasma triglycerides, lipid emulsions, herbal medicine
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