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Cited by 44Preterm Birth and ChorioamnionitisReproductive System and PregnancyMaternal and Perinatal Health Interventions

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor

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Vrachnis, Nikolaos, Malamas, Fotodotis M., Sifakis, Stavros, Tsikouras, Panayiotis, Iliodromiti, Zoe·2012·Clinical and Developmental Immunology
DOI 10.1155/2012/937618PMC PMC3199111
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Abstract

Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility. The mechanisms related to their effect differ between humans and other species, thus, despite extensive research, many questions remain to be answered regarding their mediation in human labor. Immune responses to progesterone and CRH are important for labor. Progesterone acts as an immunomodulator which controls many immune actions during pregnancy, and its withdrawal releases the inhibitory action on inflammatory pathways. In humans, a “functional” progesterone withdrawal occurs with onset of labor through changes in progesterone metabolism, progesterone receptors, and other molecules that either facilitate or antagonize progesterone function. Placental CRH acts on the fetal pituitary-adrenal axis to stimulate adrenal production of androgens and cortisol and also acts directly on myometrial cells via its receptors. CRH also affects inflammatory signals and vice versa. Interactions between progesterone and CRH additionally occur during labor. We describe the role of these two hormones in human myometrium and their interactions with the immune system during labor.

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  • The R1 subtype mediates signaling pathways that inhibit phosphorylation of contractile proteins, thereby promoting smooth muscle relaxation.

    “The R1 subtype mediates signaling pathways that inhibit phosphorylation of contractile proteins, thereby promoting smooth muscle relaxation [63].”

    From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [63]

    Section 3.2 says that CRH-R1 is suggested to promote smooth-muscle relaxation through intracellular signals that inhibit myosin light-chain phosphorylation. This supports the proposed mechanism, but the citing sentence states it as established rather than suggested. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • The direct actions of CRH on myometrial contractility involve distinct CRH receptor isoforms.

    “The direct actions of CRH on myometrial contractility involve distinct CRH receptor isoforms.”

    From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [63]

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Authors
Vrachnis, N., Malamas, F. M., Sifakis, S., Tsikouras, P., & Iliodromiti, Z.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • University Hospital of Heraklion (GR)
  • Democritus University of Thrace (GR)
  • 2nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieio Hospital, 11528 Athens, Greece
Corresponding author
Vrachnis, Nikolaos
ORCID
Venue
Clinical and Developmental Immunology
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-10
ISSN
  • 1740-2522 (ISSN-L)
  • 1740-2530
DOI
10.1155/2012/937618
PMC
PMC3199111
OpenAlex
W2026856056
Cited by
44
References
1
Citations by year
2026: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 7 · 2012: 4
FWCI
0.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical and Developmental Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords
progesterone, corticotropin-releasing factor, labor, myometrium, immunomodulation, progesterone withdrawal, progesterone receptor, cortisol, androgens, inflammation, myometrial quiescence, uterine contractility
MeSH terms
Animals, Corticotropin-Releasing Hormone, Female, Humans, Immunity, Inflammation, Labor, Obstetric, Myometrium, Pregnancy, Progesterone, Uterine Contraction, Immunomodulation

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