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Cited by 70Endoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyIon Channels and Receptors

Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus

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Su, Jing, Zhou, Lei, Kong, Xiaoxia, Yang, Xiaochun, Xiang, Xiyan, Zhang, Yu, Li, Xiaoning, Sun, Liankun·2013·Journal of Diabetes Research
DOI 10.1155/2013/193461PMC PMC3673337
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Abstract

Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide. The endoplasmic reticulum (ER) is a central component of cellular functions and is involved in protein folding and trafficking, lipid synthesis, and maintenance of calcium homeostasis. The ER is also a sensor of both intra- and extracellular stress and thus participates in monitoring and maintaining cellular homeostasis. Therefore, the ER is one site of interaction between environmental signals and a cell’s biological function. The ER is tightly linked to autophagy, inflammation, and apoptosis, and recent evidence suggests that these processes are related to the pathogenesis of DM and its complications. Thus, the ER has been considered an intersection integrating multiple stress responses and playing an important role in metabolism-related diseases including DM. Here, we review the relationship between the ER and autophagy, inflammation, and apoptosis in DM to better understand the molecular mechanisms of this disease.

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  • Sustained ER stress and maladaptive IRE1α signaling amplify inflammatory and apoptotic pathways in diabetic states.

    “Sustained ER stress and maladaptive IRE1α signaling amplify inflammatory and apoptotic pathways in diabetic states [245,246].”

    From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [245]

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Cited by

Sorted by citations

Authors
Su, J., Zhou, L., Kong, X., Yang, X., Xiang, X., Zhang, Y., Li, X., & Sun, L.
Affiliations
  • Jilin University (CN)
  • Changchun University of Chinese Medicine (CN)
  • Wenzhou Medical University (CN)
Corresponding author
Sun, Liankun
ORCID
Venue
Journal of Diabetes Research
Publisher
Hindawi Limited
Published
2013
Volume
2013
Pages
1-6
ISSN
  • 2314-6745 (ISSN-L)
  • 2314-6753
DOI
10.1155/2013/193461
PMC
PMC3673337
OpenAlex
W2096850155
Cited by
70
References
3
Citations by year
2026: 2 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 3 · 2015: 7 · 2014: 11 · 2013: 3
FWCI
0.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Diabetes Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
501100001809 National Natural Science Foundation of China (81272876, 81202552, 81200010)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
endoplasmic reticulum, diabetes mellitus, autophagy, inflammation, apoptosis, endoplasmic reticulum stress, unfolded protein response, calcium homeostasis, protein folding, lipogenesis, stress signaling, diabetes complications
MeSH terms
Animals, Autophagy, Diabetes Mellitus, Endoplasmic Reticulum, Humans, Inflammation, Signal Transduction, Apoptosis, Unfolded Protein Response, Endoplasmic Reticulum Stress

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