The molecular inflammatory process in aging

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

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The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

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NF-κB: Ten Years After

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PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

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The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

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Gene expression profile of aging and its retardation by caloric restriction

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Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

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Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

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Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

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PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

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Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

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Oxidative stress and nuclear factor-κB activation

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Regulation of cytokine signaling and inflammation

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The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

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Calorie restriction and aging: review of the literature and implications for studies in humans

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Endothelium-derived relaxing factor

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An overview on biological mechanisms of PPARs

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Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

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The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation

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Peroxynitrite reactions and formation in mitochondria

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Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

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Inducible Nitric Oxide Synthase and Inflammatory Diseases

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Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

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Multiple pathways of peroxynitrite cytotoxicity

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Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators

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Aging and oxidative stress: Modulation by dietary restriction

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Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

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Nitric oxide and oxygen radicals in infection, inflammation, and cancer.

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Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice

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Centenarians as a model for healthy aging

Franceschi, C., & Bonafè, M. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310457 · Cited by 380 · see citing works

Dietary modulation of endothelial function: implications for cardiovascular disease

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Oxidative stress and aging: beyond correlation

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Oxidized Low Density Lipoprotein Inhibits Interleukin-12 Production in Lipopolysaccharide-activated Mouse Macrophages via Direct Interactions between Peroxisome Proliferator-activated Receptor-γ and Nuclear Factor-κB

Chung, S. W., Kang, B. Y., Kim, S. H., Pak, Y. K., Cho, D., Trinchieri, G., & Kim, T. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002577200 · Cited by 336 · see citing works

Role of inflammation in neurodegenerative diseases

Minghetti, L. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000169752.54191.97 · Cited by 335 · see citing works

Aging and oxidative stress

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Reactive oxygen species and angiotensin II signaling in vascular cells: implications in cardiovascular disease

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Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation

Blanquart, C., Barbier, O., Fruchart, J., Staels, B., & Glineur, C. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00214-0 · Cited by 312 · see citing works

Expression of Constitutive and Inducible Nitric Oxide Synthases in the Vascular Wall of Young and Aging Rats

Cernadas, M. R., de Miguel, L. S., Garcı́a-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, A. P., de Frutos, T., et al. (1998) · Circulation Research · doi:10.1161/01.res.83.3.279 · Cited by 310 · see citing works

Role of redox-regulated transcription factors in inflammation, aging and age-related diseases

Lavrovsky, Y. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00118-2 · Cited by 305 · see citing works

The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction

Chung, H. Y., Kim, H. J., Kim, J. W., & Yu, B. P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05662.x · Cited by 305 · see citing works

Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction

Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10203 · Cited by 297 · see citing works

Nuclear factor–kB in rheumatoid synovium. Localization of P50 and P65

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Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation

Savage, D. B., Petersen, K. F., & Shulman, G. I. (2005) · Hypertension · doi:10.1161/01.hyp.0000163475.04421.e4 · Cited by 284 · see citing works

Dietary Restriction and Aging

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Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB

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Peroxisome Proliferator-Activated Receptor-α Activation as a Mechanism of Preventive Neuroprotection Induced by Chronic Fenofibrate Treatment

Deplanque, D., Gelé, P., Pétrault, O., Six, I., Furman, C., Bouly, M., Nion, S., Dupuis, B., Leys, D., Fruchart, J., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06264.2003 · Cited by 219 · see citing works

Aging, Longevity, Inflammation, and Cancer

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Aging-induced Up-regulation of Nuclear Binding Activities of Oxidative Stress Responsive NF-kB Transcription Factor in Mouse Cardiac Muscle

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Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines

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The effect of age on cyclooxygenase-2 gene expression

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MOLECULAR REGULATION OF THE HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS) GENE

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Rat Aortic MCP-1 and Its Receptor CCR2 Increase With Age and Alter Vascular Smooth Muscle Cell Function

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PPARγ activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes

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Modulation of redox-sensitive transcription factors by calorie restriction during aging

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Critical Evaluation of the Free Radical Theory of Aging

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Effects of Adipocyte-Derived Cytokines on Endothelial Functions: Implication of Vascular Disease

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Molecular Mechanisms Mediating Inflammation in Vascular Disease

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Antioxidative, Antinitrative, and Vasculoprotective Effects of a Peroxisome Proliferator–Activated Receptor-γ Agonist in Hypercholesterolemia

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Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging

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Modulation of PPAR in Aging, Inflammation, and Calorie Restriction

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Age-related changes in the regulation of transcription factor NF-κB in rat brain

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Stress Resistance by Caloric Restriction for Longevity

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Biphasic Regulation of Leukocyte Superoxide Generation by Nitric Oxide and Peroxynitrite

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TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK Activation, NF-κB Activation, and Apoptosis

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PPARs as Drug Targets to Modulate Inflammatory Responses?

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Suppression of age-related inflammatory NF-κB activation by cinnamaldehyde

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Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

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Dietary Restriction and Aging: Historical Phases, Mechanisms and Current Directions

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Peroxisome Proliferator-Activated Receptors (PPARs): from metabolic control to epidermal wound healing

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Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction

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Vitamin E and Macrophage Cyclooxygenase Regulation in the Aged

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Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-kappaB.

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Different Mitogen-activated Protein Kinase Signaling Pathways Cooperate to Regulate Tumor Necrosis Factor α Gene Expression in T Lymphocytes

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Inflammation in End-Stage Renal Disease – A Fire that Burns within

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Cooperation of heat shock protein 90 and p23 in aryl hydrocarbon receptor signaling

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Zinc Modulates PPARγ Signaling and Activation of Porcine Endothelial Cells

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Molecular exploration of age-related NF-κB/IKK downregulation by calorie restriction in rat kidney

Kim, H.-J., Yu, B.-P., & Chung, H. Y. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00798-0 · Cited by 80 · see citing works

Mechanism of age-associated up-regulation in macrophage PGE2 synthesis

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Oxidative stress and vascular aging

Yu, B. P., & Chung, H. Y. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00338-2 · Cited by 78 · see citing works

Adipose Tissue Interleukin‐18 mRNA and Plasma Interleukin‐18: Effect of Obesity and Exercise

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Upregulation of Aortic Adhesion Molecules During Aging

Zou, Y., Yoon, S. Y., Jung, K. J., Kim, C. H., Son, T. G., Kim, M.-S., Kim, Y. J., Lee, J., Yu, B. P., & Chung, H. Y. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.3.232 · Cited by 69 · see citing works

Modulation of the age‐related nuclear factor‐κB (NF‐κB) pathway by hesperetin

Kim, J., Jung, K. J., Choi, J. S., & Chung, H. Y. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00233.x · Cited by 68 · see citing works

Influence of aging and calorie restriction on MAPKs activity in rat kidney

Kim, H. J., Jung, K. J., Yu, B. P., Cho, C. G., & Chung, H. Y. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00082-7 · Cited by 68 · see citing works

The role of PPARs in the transcriptional control of cellular processes

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Enhanced Proliferation and Migration and Altered Cytoskeletal Proteins in Early Passage Smooth Muscle Cells from Young and Old Rat Aortic Explants

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The inflammatory process in aging

Yu, B. P., & Chung, H. Y. (2006) · Reviews in Clinical Gerontology · doi:10.1017/s0959259807002110 · Cited by 65 · see citing works

The effect of age and calorie restriction on HIF-1-responsive genes in aged liver

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Aging decreases the production of PGI2 in rat aortic endothelial cells

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The Functions of PPARs in Aging and Longevity

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Chronic caloric restriction induces forestomach hypertrophy with enhanced ghrelin levels during aging

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Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians

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Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet

Bhattacharya, A., Chandrasekar, B., Rahman, M. M., Banu, J., Kang, J. X., & Fernandes, G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.093 · Cited by 51 · see citing works

Betaine Modulates Age-Related NF-.KAPPA.B by Thiol-Enhancing Action

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Conserved and Tissue-Specific Genic and Physiologic Responses to Caloric Restriction and Altered IGFI Signaling in Mitotic and Postmitotic Tissues

Spindler, S. R., & Dhahbi, J. M. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093743 · Cited by 49 · see citing works

Ceramide Mediates Age-associated Increase in Macrophage Cyclooxygenase-2 Expression

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