The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells
Open accessAbstract
Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells and result in oxidative and nitrative DNA damage, such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has been implicated in the initiation and/or promotion of inflammation-mediated carcinogenesis. It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1), including parasites (Schistosoma haematobium(SH) and Opisthorchis viverrini(OV)), viruses (hepatitis C virus (HCV), human papillomavirus (HPV), and Epstein-Barr virus (EBV)), and bacterium Helicobacter pylori(HP). SH, OV, HCV, HPV, EBV, and HP are important risk factors for bladder cancer, cholangiocarcinoma, hepatocellular carcinoma, cervical cancer, nasopharyngeal carcinoma, and gastric cancer, respectively. We demonstrated that 8-nitroguanine was strongly formed via inducible nitric oxide synthase (iNOS) expression at these cancer sites of patients. Moreover, 8-nitroguanine was formed in Oct3/4-positive stem cells in SH-associated bladder cancer tissues and in Oct3/4- and CD133-positive stem cells in OV-associated cholangiocarcinoma tissues. Therefore, it is considered that oxidative and nitrative DNA damage in stem cells may play a key role in inflammation-related carcinogenesis.
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Cites
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
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Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
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Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma
Thanan, R., Oikawa, S., Yongvanit, P., Hiraku, Y., Ma, N., Pinlaor, S., Pairojkul, C., Wongkham, C., Sripa, B., Khuntikeo, N., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.018 · Cited by 70
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Thanan, R., Oikawa, S., Hiraku, Y., Ohnishi, S., Ma, N., Pinlaor, S., Yongvanit, P., Kawanishi, S., & Murata, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010193 · Cited by 455
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Metadata
- Authors
- Ohnishi, S., Ma, N., Thanan, R., Pinlaor, S., Hammam, O., Murata, M., & Kawanishi, S.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-9
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2097560466
- Cited by
- 207
- References
- 5
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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