The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Microglia Control Neuronal Network Excitability via BDNF Signalling
Open accessAbstract
Microglia‐neuron interactions play a crucial role in several neurological disorders characterized by altered neural network excitability, such as epilepsy and neuropathic pain. While a series of potential messengers have been postulated as substrates of the communication between microglia and neurons, including cytokines, purines, prostaglandins, and nitric oxide, the specific links between messengers, microglia, neuronal networks, and diseases have remained elusive. Brain‐derived neurotrophic factor (BDNF) released by microglia emerges as an exception in this riddle. Here, we review the current knowledge on the role played by microglial BDNF in controlling neuronal excitability by causing disinhibition. The efforts made by different laboratories during the last decade have collectively provided a robust mechanistic paradigm which elucidates the mechanisms involved in the synthesis and release of BDNF from microglia, the downstream TrkB‐mediated signals in neurons, and the biophysical mechanism by which disinhibition occurs, via the downregulation of the K + ‐Cl − cotransporter KCC2, dysrupting Cl − homeostasis, and hence the strength of GABA A ‐ and glycine receptor‐mediated inhibition. The resulting altered network activity appears to explain several features of the associated pathologies. Targeting the molecular players involved in this canonical signaling pathway may lead to novel therapeutic approach for ameliorating a wide array of neural dysfunctions.
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Inflammatory Response in the CNS: Friend or Foe?
Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573
Bidirectional Microglia–Neuron Communication in Health and Disease
Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459
Hellwig, S., Brioschi, S., Dieni, S., Frings, L., Masuch, A., Blank, T., & Biber, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.008 · Cited by 252
Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission
Marinelli, S., Basilico, B., Marrone, M. C., & Ragozzino, D. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.05.017 · Cited by 233
Normal and abnormal coding of somatosensory stimuli causing pain
Prescott, S. A., Ma, Q., & De Koninck, Y. (2014) · Nature Neuroscience · doi:10.1038/nn.3629 · Cited by 210
Metadata
- Authors
- Ferrini, F., & De Koninck, Y.
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 2013
- Issue
- 1
- Pages
- 429815-429815
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- OpenAlex
- W2099030247
- Cited by
- 318
- References
- 130
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- gold
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