Normal and abnormal coding of somatosensory stimuli causing pain
Open accessAbstract
Noxious stimuli usually cause pain and pain usually arises from noxious stimuli, but exceptions to these apparent truisms are the basis for clinically important problems and provide valuable insight into the neural code for pain. In this Review, we discuss how painful sensations arise. We argue that, although primary somatosensory afferents are tuned to specific stimulus features, natural stimuli often activate more than one type of afferent. Manipulating coactivation patterns can alter perception in ways that argue against each type of afferent acting independently (as expected for strictly labeled lines), suggesting instead that signals conveyed by different types of afferents interact. Deciphering the central circuits that mediate those interactions is critical for explaining the generation and modulation of neural signals that ultimately elicit pain. The advent of genetic and optical dissection techniques promise to dramatically accelerate progress toward this goal, which will facilitate the rational design of future pain therapeutics.
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Many studies have investigated the relationship between optogenetic stimulation and neurological disorders and control, including Parkinson's, Alzheimer's, spinal cord injuries, and somatosensory nociception, which relate to prosthetic control, feedback, and human movement rehabilitation.
“Many studies have delved into the relationship between optogenetic stimulation and neurological disorders and control, such as Parkinson's,[557] Alzheimer's,[558] spinal cord injuries,[559] and somatosensory nociception,[560,561] which have indistinguishable relationship with prosthetic control, feedback, and human movement rehabilitation.”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [558]
Nerve injury induces hyperexcitability, causing functional alterations such as loss of function of inhibitory neurons in the dorsal horn, and results in neuropathic pain.
“Nerve injury induces hyperexcitability, thereby causing functional alterations in the neuronal network such as loss of function of inhibitory neurons in the dorsal horn, and results in neuropathic pain (Prescott et al, 2014;Todd, 2010).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Prescott et al, 2014
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A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486 · see citing works
A theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578 · see citing works
The Bayesian brain: The role of uncertainty in neural coding and computation
Knill, D. C., & Pouget, A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.007 · Cited by 2,588 · see citing works
Combinatorial Receptor Codes for Odors
Malnic, B., Hirono, J., Sato, T., & Buck, L. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80581-4 · Cited by 2,302 · see citing works
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076 · see citing works
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works
Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
Costigan, M., Scholz, J., & Woolf, C. J. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135531 · Cited by 2,025 · see citing works
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
The Petilla Interneuron Nomenclature Group (PING) (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2402 · Cited by 1,491 · see citing works
Whole-brain functional imaging at cellular resolution using light-sheet microscopy
Ahrens, M. B., Orger, M. B., Robson, D. N., Li, J. M., & Keller, P. J. (2013) · Nature Methods · doi:10.1038/nmeth.2434 · Cited by 1,392 · see citing works
Topographic organization of sensory projections to the olfactory bulb
Vassar, R. J., Chao, S. K., Sitcheran, R., ̃ez, J. M. N., Vosshall, L. B., & Axel, R. (1994) · Cell · doi:10.1016/0092-8674(94)90029-9 · Cited by 1,281 · see citing works
An Expanded Palette of Genetically Encoded Ca 2+ Indicators
Zhao, Y., Araki, S., Wu, J., Teramoto, T., Chang, Y.-F., Nakano, M., Abdelfattah, A. S., Fujiwara, M., Ishihara, T., Nagai, T., et al. (2011) · Science · doi:10.1126/science.1208592 · Cited by 1,265 · see citing works
Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons
Wickersham, I. R., Lyon, D. C., Barnard, R. J. O., Mori, T., Finke, S., Conzelmann, K., Young, J. A. T., & Callaway, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.033 · Cited by 1,176 · see citing works
Miniaturized integration of a fluorescence microscope
Ghosh, K. K., Burns, L. D., Cocker, E. D., Nimmerjahn, A., Ziv, Y., Gamal, A. E., & Schnitzer, M. J. (2011) · Nature Methods · doi:10.1038/nmeth.1694 · Cited by 1,130 · see citing works
Maier, C., Baron, R., Tölle, T. R., Binder, A., Birbaumer, N., Birklein, F., Gierthmühlen, J., Flor, H., Geber, C., Huge, V., et al. (2010) · Pain · doi:10.1016/j.pain.2010.05.002 · Cited by 1,021 · see citing works
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
Buch, T., Heppner, F. L., Tertilt, C., Heinen, T. J. A. J., Kremer, M., Wunderlich, F. T., Jung, S., & Waisman, A. (2005) · Nature Methods · doi:10.1038/nmeth762 · Cited by 922 · see citing works
Kobayashi, K., Fukuoka, T., Obata, K., Yamanaka, H., Dai, Y., Tokunaga, A., & Noguchi, K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20794 · Cited by 766 · see citing works
Optogenetic investigation of neural circuits underlying brain disease in animal models
Tye, K. M., & Deisseroth, K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3171 · Cited by 745 · see citing works
Mantyh, P. W., Rogers, S. D., Honoré, P., Allen, B. J., Ghilardi, J. R., Li, J., Daughters, R. S., Lappi, D. A., Wiley, R. G., & Simone, D. A. (1997) · Science · doi:10.1126/science.278.5336.275 · Cited by 634 · see citing works
Probabilistic brains: knowns and unknowns
Pouget, A., Beck, J. M., Ma, W. J., & Latham, P. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3495 · Cited by 615 · see citing works
Cellular Basis of Itch Sensation
Sun, Y.-G., Zhao, Z.-Q., Meng, X.-L., Yin, J., Liu, X., & Chen, Z. (2009) · Science · doi:10.1126/science.1174868 · Cited by 612 · see citing works
小林, 希. (2007) · Medical Entomology and Zoology · Cited by 575 · see citing works
Central mechanisms of odour object perception
Gottfried, J. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2883 · Cited by 549 · see citing works
Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice
Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Noda, M., Inui, Y., Mekada, E., Kimata, Y., Tsuru, A., & Kohno, K. (2001) · Nature Biotechnology · doi:10.1038/90795 · Cited by 512 · see citing works
The Cells and Circuitry for Itch Responses in Mice
Mishra, S. K., & Hoon, M. A. (2013) · Science · doi:10.1126/science.1233765 · Cited by 507 · see citing works
The Thermal Grill Illusion: Unmasking the Burn of Cold Pain
Craig, A. D., & Bushnell, M. C. (1994) · Science · doi:10.1126/science.8023144 · Cited by 497 · see citing works
Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
Ross, S. E., Mardinly, A. R., McCord, A. E., Zurawski, J. D., Cohen, S., Jung, C. C., Hu, L. S., Mok, S. I., Shah, A., Savner, E. M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.025 · Cited by 445 · see citing works
Self-citationThe machinery of colour vision
Solomon, S. G., & Lennie, P. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2094 · Cited by 436 · see citing works
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
Andersson, L. S., Larhammar, M., Memic, F., Wootz, H., Schwochow, D., Rubin, C., Patra, K., Árnason, T., Wellbring, L., Hjälm, G., et al. (2012) · Nature · doi:10.1038/nature11399 · Cited by 431 · see citing works
Torsney, C., & MacDermott, A. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4584-05.2006 · Cited by 407 · see citing works
Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
Gross, M. K., Dottori, M., & Goulding, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00690-6 · Cited by 396 · see citing works
Müller, T., Brohmann, H., Pierani, A., Heppenstall, P. A., Lewin, G. R., Jessell, T. M., & Birchmeier, C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00689-x · Cited by 368 · see citing works
Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition
Ray, R. S., Corcoran, A. E., Brust, R. D., Kim, J. C., Richerson, G. B., Nattie, E., & Dymecki, S. M. (2011) · Science · doi:10.1126/science.1205295 · Cited by 363 · see citing works
Specification of dorsal spinal cord interneurons
Helms, A. W., & Johnson, J. E. B. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00010-2 · Cited by 357 · see citing works
Chloride extrusion enhancers as novel therapeutics for neurological diseases
Gagnon, M., Bergeron, M. J., Lavertu, G., Castonguay, A., Tripathy, S., Bonin, R. P., Pérez-Sánchez, J., Boudreau, D., Wang, B., Dumas, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3356 · Cited by 357 · see citing works
Nanotools for Neuroscience and Brain Activity Mapping
Alivisatos, A. P., Andrews, A. M., Boyden, E. S., Chun, M., Church, G. M., Deisseroth, K. A., Donoghue, J. P., Fraser, S. E., Lippincott‐Schwartz, J., Looger, L. L., et al. (2013) · ACS Nano · doi:10.1021/nn4012847 · Cited by 353 · see citing works
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P. A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1221 · Cited by 350 · see citing works
Self-citationTargeting neurons and photons for optogenetics
Packer, A. M., Roska, B., & Häusser, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3427 · Cited by 345 · see citing works
Todd, A. J., & SPIKE, R. C. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90045-t · Cited by 330 · see citing works
Microglia Control Neuronal Network Excitability via BDNF Signalling
Ferrini, F., & Koninck, Y. D. (2013) · Neural Plasticity · doi:10.1155/2013/429815 · Cited by 321 · see citing works
Churchland, P. S., Ramachandran, V. S., & B, T. J. S. A. (1993) · PhilPapers (PhilPapers Foundation) · Cited by 304 · see citing works
Proprioceptor Pathway Development Is Dependent on MATH1
Bermingham, N. A., Hassan, B. A., Wang, V. Y., Fernandez, M., Banfi, S., Bellen, H. J., Fritzsch, B., & Zoghbi, H. Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00305-1 · Cited by 304 · see citing works
A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia
Lü, Y., Dong, H., Gao, Y., Gong, Y., Ren, Y., Gu, N., Zhou, S., Xia, N., Sun, Y., Ji, R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70026 · Cited by 287 · see citing works
A Specific Inhibitory Pathway between Substantia Gelatinosa Neurons Receiving Direct C-Fiber Input
Lü, Y., & Perl, E. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08752.2003 · Cited by 286 · see citing works
Fibre function and perception during cutaneous nerve block.
Mackenzie, R. A., Burke, D. J., Skuse, N. F., & Lethlean, A. K. (1975) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.38.9.865 · Cited by 274 · see citing works
Baba, H., Ji, R., Kohno, T., Moore, K. A., Ataka, T., Wakai, A., Okamoto, M., & Woolf, C. J. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00236-7 · Cited by 274 · see citing works
Placebo analgesia: Psychological and neurobiological mechanisms
Colloca, L., Klinger, R., Flor, H., & Bingel, U. (2013) · Pain · doi:10.1016/j.pain.2013.02.002 · Cited by 263 · see citing works
Keller, A. F., Beggs, S., Salter, M. W., & Koninck, Y. D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-27 · Cited by 262 · see citing works
Lü, Y., & Perl, E. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0102-05.2005 · Cited by 255 · see citing works
Ideas about pain, a historical view
Perl, E. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2042 · Cited by 249 · see citing works
Isbister, G. K., & Kiernan, M. C. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70041-7 · Cited by 241 · see citing works
Optogenetic pharmacology for control of native neuronal signaling proteins
Krämer, R., Mourot, A., & Adesnik, H. (2013) · Nature Neuroscience · doi:10.1038/nn.3424 · Cited by 240 · see citing works
Melzack, R., Wall, P. D., & Ty, T. C. (1982) · Pain · doi:10.1016/0304-3959(82)90078-1 · Cited by 236 · see citing works
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn
Glasgow, S. M., Henke, R. M., MacDonald, R. J., Wright, C. V. E., & Johnson, J. E. (2005) · Development · doi:10.1242/dev.02167 · Cited by 225 · see citing works
Physiological Properties of the Lamina I Spinoparabrachial Neurons in the Rat
Bester, H., Chapman, V., Besson, J., & Bernard, J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.2239 · Cited by 223 · see citing works
RELEASE OF COLD-INDUCED BURNING PAIN BY BLOCK OF COLD-SPECIFIC AFFERENT INPUT
Yarnitsky, D., & Ochoa, J. L. (1990) · Brain · doi:10.1093/brain/113.4.893 · Cited by 220 · see citing works
Color Vision, Cones, and Color-Coding in the Cortex
Conway, B. R. (2009) · The Neuroscientist · doi:10.1177/1073858408331369 · Cited by 210 · see citing works
Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons
Miraucourt, L. S., Dallel, R., & Voisin, D. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001116 · Cited by 208 · see citing works
Cheng, L., Samad, O. A., Xu, Y., Mizuguchi, R., Luo, P., Shirasawa, S., Goulding, M., & Ma, Q. (2005) · Nature Neuroscience · doi:10.1038/nn1569 · Cited by 198 · see citing works
Self-citationRemote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice
Daou, I., Tuttle, A. H., Longo, G., Wieskopf, J. S., Bonin, R. P., Ase, A. R., Wood, J. N., De Koninck, Y., Ribeiro-da-Silva, A., Mogil, J. S., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2424-13.2013 · Cited by 175 · see citing works
Labeled lines meet and talk: population coding of somatic sensations
Ma, Q. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43426 · Cited by 171 · see citing works
Self-citationSensory determinants of thermal pain
Defrin, R., Ohry, A., Blumen, N., & Urca, G. (2002) · Brain · doi:10.1093/brain/awf055 · Cited by 169 · see citing works
Sikand, P., Shimada, S. G., Green, B. G., & LaMotte, R. H. (2009) · Pain · doi:10.1016/j.pain.2009.03.001 · Cited by 160 · see citing works
A microprobe for parallel optical and electrical recordings from single neurons in vivo
LeChasseur, Y., Dufour, S., Lavertu, G., Bories, C., Deschênes, M., Vallée, R., & Koninck, Y. D. (2011) · Nature Methods · doi:10.1038/nmeth.1572 · Cited by 157 · see citing works
Human cutaneous C fibres activated by cooling, heating and menthol
Campero, M., Baumann, T., Bostock, H., & Ochoa, J. L. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.176040 · Cited by 154 · see citing works
Hughes, D. I., Sikander, S., Kinnon, C. M., Boyle, K. A., Watanabe, M., Callister, R. J., & Graham, B. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.235655 · Cited by 151 · see citing works
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
Müller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M., & Birchmeier, C. (2005) · Genes & Development · doi:10.1101/gad.326105 · Cited by 150 · see citing works
Luxotonic responses of units in macaque striate cortex.
Kayama, Y., Riso, R. R., Bartlett, J. R., & Doty, R. W. (1979) · Journal of Neurophysiology · doi:10.1152/jn.1979.42.6.1495 · Cited by 138 · see citing works
Circuits for Grasping: Spinal dI3 Interneurons Mediate Cutaneous Control of Motor Behavior
Bui, T. V., Akay, T., Loubani, O. M., Hnasko, T. S., Jessell, T. M., & Brownstone, R. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.007 · Cited by 135 · see citing works
Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats
Carstens, E. E., Carstens, M. I., Simons, C. T., & Jinks, S. L. (2010) · Neuroreport · doi:10.1097/wnr.0b013e328337310a · Cited by 135 · see citing works
Linking Genetically Defined Neurons to Behavior through a Broadly Applicable Silencing Allele
Kim, J. C., Cook, M. N., Carey, M. R., Shen, C., Regehr, W. G., & Dymecki, S. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.010 · Cited by 134 · see citing works
Chen, Z., Rebelo, S., White, F. A., Malmberg, A. B., Baba, H., Lima, D., Woolf, C. J., Basbaum, A. I., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00341-5 · Cited by 133 · see citing works
Wang, X., Zhang, J., Eberhart, D. E., Urban, R., Meda, K., Solórzano, C., Yamanaka, H., Rice, D. S., & Basbaum, A. I. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.001 · Cited by 127 · see citing works
Ochoa, J. L., & Yarnitsky, D. (1994) · Brain · doi:10.1093/brain/117.1.185 · Cited by 127 · see citing works
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
Vetter, I., Touška, F., Hess, A., Hinsbey, R., Sattler, S., Lampert, A., Sergejeva, M., Sharov, A., Collins, L. S., Eberhardt, M. J., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.207 · Cited by 116 · see citing works
Molecular Neuroanatomy's “Three Gs”: A Primer
Dymecki, S. M., & Kim, J. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.009 · Cited by 110 · see citing works
Zheng, J., Lü, Y., & Perl, E. R. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.188052 · Cited by 102 · see citing works
CONGENITAL UNIVERSAL INSENSITIVITY TO PAIN
BAXTER, D. W., & Olszewski, J. (1960) · Brain · doi:10.1093/brain/83.3.381 · Cited by 100 · see citing works
Huang, M.-G., Huang, T., Xiang, Y., Xie, Z., Chen, Y., Yan, R., Xu, J., & Cheng, L.-P. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.06.031 · Cited by 99 · see citing works
Polgár, E., Sardella, T. C. P., Tiong, S. Y. X., Locke, S., Watanabe, M., & Todd, A. J. (2013) · Pain · doi:10.1016/j.pain.2013.05.001 · Cited by 93 · see citing works
Bröhl, D., Strehle, M., Wende, H., Hori, K., Bormuth, I., Nave, K., Müller, T. H., & Birchmeier, C. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.002 · Cited by 90 · see citing works
Free-Energy and Illusions: The Cornsweet Effect
Brown, H. R., & Friston, K. J. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00043 · Cited by 88 · see citing works
Takazawa, T., & MacDermott, A. B. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.188292 · Cited by 87 · see citing works
Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons
Xu, Y., Lopes, C., Qian, Y., Liu, Y., Cheng, L., Goulding, M., Turner, E. E., Lima, D., & Ma, Q. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4126-07.2008 · Cited by 76 · see citing works
Self-citationPopulation coding of somatic sensations
Ma, Q. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1201-2 · Cited by 75 · see citing works
Self-citationAdaptive Movement Compensation for In Vivo Imaging of Fast Cellular Dynamics within a Moving Tissue
Laffray, S., Pagès, S., Dufour, H., Koninck, P. D., Koninck, Y. D., & Côté, D. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019928 · Cited by 73 · see citing works
Mesnage, B., Gaillard, S., Godin, A. G., Rodeau, J., Hammer, M., Von Engelhardt, J., Wiseman, P. W., De Koninck, Y., Schlichter, R., & Cordero‐Erausquin, M. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22668 · Cited by 71 · see citing works
Enhancing K–Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model
Lavertu, G., Côté, S., & Koninck, Y. D. (2013) · Brain · doi:10.1093/brain/awt334 · Cited by 71 · see citing works
Representation of pain in the brain
Bushnell, M. C., & Apkarian, A. V. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50011-4 · Cited by 68 · see citing works
Green, B. G., & Pope, J. V. (2003) · Experimental Brain Research · doi:10.1007/s00221-002-1280-9 · Cited by 66 · see citing works
Functional imaging in freely moving animals
Kerr, J. N. D., & Nimmerjahn, A. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.002 · Cited by 65 · see citing works
Ontogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities
Xu, Y., Lopes, C., Wende, H., Guo, Z., Cheng, L., Birchmeier, C., & Ma, Q. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5512-12.2013 · Cited by 63 · see citing works
Self-citationA STUDY OF POST-ISCHAeMIC PARAeSTHESIAe
Merrington, W. R., & Nathan, P. W. (1949) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.12.1.1 · Cited by 59 · see citing works
Pain processing by spinal microcircuits: afferent combinatorics
Prescott, S. A., & Ratté, S. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.02.010 · Cited by 57 · see citing works
Self-citationInhibitory Coupling between Inhibitory Interneurons in the Spinal Cord Dorsal Horn
Labrakakis, C., Lorenzo, L.-É., Bories, C., Ribeiro‐da‐Silva, A., & Koninck, Y. D. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-24 · Cited by 56 · see citing works
Paradoxical heat sensations during moderate cooling of the skin
̈inen, H. H. ̈. ̈., Vartiainen, M. A., Karvanen, L., & Järvilehto, T. (1982) · Brain Research · doi:10.1016/0006-8993(82)91275-6 · Cited by 52 · see citing works
Cordero‐Erausquin, M., Allard, S., Dolique, T., Bachand, K., Ribeiro‐da‐Silva, A., & Koninck, Y. D. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22179 · Cited by 51 · see citing works
Morphological and Neurochemical Organization of the Spinal Dorsal Horn
Ribeiro‐da‐Silva, A., & Koninck, Y. D. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00163-8 · Cited by 48 · see citing works
Bélanger, E., Crépeau, J., Laffray, S., Vallée, R., Koninck, Y. D., & Côté, D. C. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.2.021107 · Cited by 45 · see citing works
Guo, Z., Zhao, C., Huang, M.-G., Huang, T., Fan, M., Xie, Z., Chen, Y., Zhao, X., Xia, G., Geng, J., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6301-11.2012 · Cited by 39 · see citing works
Can the basis for central neuropathic pain be identified by using a thermal grill?
Craig, A. D. (2008) · Pain · doi:10.1016/j.pain.2008.01.022 · Cited by 30 · see citing works
ISCHAEMIC AND POST-ISCHAEMIC NUMBNESS AND PARAESTHESIAE
Nathan, P. W. (1958) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.21.1.12 · Cited by 29 · see citing works
Odorant receptor diversity and patterned gene expression in the mammalian olfactory epithelium.
Sullivan, S. L., Ressler, K. J., & Buck, L. B. (1994) · PubMed · Cited by 28 · see citing works
Laminar optical tomography of the hemodynamic response in the lumbar spinal cord of rats
Ouakli, N., Guevara, E., Dubeau, S., Beaumont, É., & Lesage, F. (2010) · Optics Express · doi:10.1364/oe.18.010068 · Cited by 25 · see citing works
Green, B. G., & Schoen, K. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.015 · Cited by 21 · see citing works
Dunfield, D., & Haas, K. Z. (2010) · Nature Protocols · doi:10.1038/nprot.2010.10 · Cited by 11 · see citing works
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Transition from acute to chronic pain after surgery
Glare, P., Aubrey, K. R., & Myles, P. S. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30352-6 · Cited by 914 · see citing works
Structural plasticity and reorganisation in chronic pain
Kuner, R., & Flor, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.162 · Cited by 700 · see citing works
Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics
Heng, W., Solomon, S., & Gao, W. (2022) · Advanced Materials · doi:10.1002/adma.202107902 · Cited by 609 · see citing works
Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.003 · Cited by 582 · see citing works
Self-citationHäring, M., Zeisel, A., Hochgerner, H., Rinwa, P., Jakobsson, J. E. T., Lönnerberg, P., La Manno, G., Sharma, N., Borgius, L., Kiehn, O., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0141-1 · Cited by 470 · see citing works
Etiology and Pharmacology of Neuropathic Pain
Alles, S. R. A., & Smith, P. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014399 · Cited by 395 · see citing works
Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
Kardon, A. P., Polgár, E., Hachisuka, J., Snyder, L. M., Cameron, D., Savage, S., Cai, X., Karnup, S., Fan, C. R., Hemenway, G. M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.046 · Cited by 369 · see citing works
Specialized cutaneous Schwann cells initiate pain sensation
Abdo, H., Calvo-Enrique, L., Martínez‐López, J. A., Song, J., Zhang, M.-D., Usoskin, D., Manira, A. E., Adameyko, I. I., Hjerling‐Leffler, J., & Ernfors, P. (2019) · Science · doi:10.1126/science.aax6452 · Cited by 361 · see citing works
Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain
Kuner, R., & Kuner, T. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2019 · Cited by 342 · see citing works
Dorsal Horn Circuits for Persistent Mechanical Pain
Peirs, C., Williams, S.-P. G., Zhao, X., Walsh, C. E., Gedeon, J. Y., Cagle, N. E., Goldring, A. C., Hioki, H., Liu, Z., Marell, P. S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.029 · Cited by 327 · see citing works
Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury
Petitjean, H., Pawlowski, S. A., Fraine, S. L., Sharif, B., Hamad, D., Fatima, T., Berg, J., Brown, C. M., Jan, L.-Y., Ribeiro-da-Silva, A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.080 · Cited by 326 · see citing works
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
The search for pain biomarkers in the human brain
Mouraux, A., & Iannetti, G. D. (2018) · Brain · doi:10.1093/brain/awy281 · Cited by 286 · see citing works
Keep Calm and Cuddle on: Social Touch as a Stress Buffer
Morrison, I. (2016) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-016-0052-x · Cited by 256 · see citing works
Spinal Circuits for Touch, Pain, and Itch
Koch, S. C., Acton, D. G., & Goulding, M. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034303 · Cited by 248 · see citing works
Microglia in the spinal cord and neuropathic pain
Tsuda, M. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12379 · Cited by 238 · see citing works
Arcourt, A., Gorham, L., Dhandapani, R., Prato, V., Taberner, F. J., Wende, H., Gangadharan, V., Birchmeier, C., Heppenstall, P. A., & Lechner, S. G. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.027 · Cited by 213 · see citing works
Pathology of pain and its implications for therapeutic interventions
Cao, B., Xu, Q., Shi, Y., Zhao, R., Li, H., Zheng, J., Liu, F., Wan, Y., & Wei, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01845-w · Cited by 220 · see citing works
Tsuda, M., Koga, K., Chen, T., & Zhuo, M. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14001 · Cited by 167 · see citing works
Central circuit mechanisms of itch
Chen, X., & Sun, Y.-G. (2020) · Nature Communications · doi:10.1038/s41467-020-16859-5 · Cited by 169 · see citing works
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem
Ghazisaeidi, S., Muley, M. M., & Salter, M. W. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051421-112259 · Cited by 169 · see citing works
Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system
Montgomery, K. L., Iyer, S. M., Christensen, A. J., Deisseroth, K., & Delp, S. L. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7577 · Cited by 147 · see citing works
Rösner, J., de Andrade, D. C., Davis, K. D., Gustin, S. M., Kramer, J. L. K., Seal, R. P., & Finnerup, N. B. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00484-9 · Cited by 155 · see citing works
Zhou, J., Xiong, Q., Chen, H., Yang, C., & Fan, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00091 · Cited by 141 · see citing works
Hildebrand, M. E., Xu, J., Dedek, A., Li, Y., Sengar, A. S., Beggs, S., Lombroso, P. J., & Salter, M. W. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.024 · Cited by 139 · see citing works
Neuropathic pain caused by miswiring and abnormal end organ targeting
Gangadharan, V., Zheng, H., Taberner, F. J., Landry, J. J. M., Nees, T. A., Pistolic, J., Agarwal, N., Männich, D., Beneš, V., Helmstaedter, M. N., et al. (2022) · Nature · doi:10.1038/s41586-022-04777-z · Cited by 138 · see citing works
Sensory Afferents Use Different Coding Strategies for Heat and Cold
Wang, F., Bélanger, E., Côté, S., Desrosiers, P., Prescott, S. A., Côté, D. C., & Koninck, Y. D. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.065 · Cited by 133 · see citing works
Self-citationSpinal Circuits Transmitting Mechanical Pain and Itch
Duan, B., Cheng, L., & Ma, Q. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0136-z · Cited by 132 · see citing works
Self-citationPsychological therapy for centralized pain: an integrative assessment and treatment model
Lumley, M. A., & Schubiner, H. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000654 · Cited by 116 · see citing works
Spinal presynaptic inhibition in pain control
Guo, D., & Hu, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.032 · Cited by 113 · see citing works
A functional subdivision within the somatosensory system and its implications for pain research
Ma, Q. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.015 · Cited by 109 · see citing works
Self-citationBoakye, P. A., Tang, S.-J., & Smith, P. A. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.698157 · Cited by 102 · see citing works
The dorsal spinal cord and hindbrain: From developmental mechanisms to functional circuits.
Hernandez-Miranda, L. R., Müller, T., & Birchmeier, C. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2016.10.008 · Cited by 88 · see citing works
Molecular and cellular mechanisms that initiate pain and itch
Luo, J., Feng, J., Liu, S., Walters, E. T., & Hu, H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1904-4 · Cited by 93 · see citing works
A new minimally-invasive method for microinjection into the mouse spinal dorsal horn
Kohro, Y., Sakaguchi, E., Tashima, R., Tozaki‐Saitoh, H., Okano, H., Inoue, K., & Tsuda, M. (2015) · Scientific Reports · doi:10.1038/srep14306 · Cited by 92 · see citing works
Smith, K. M., Boyle, K. A., Madden, J. F., Dickinson, S. A., Jobling, P., Callister, R. J., Hughes, D. I., & Graham, B. A. (2015) · The Journal of Physiology · doi:10.1113/jp270855 · Cited by 88 · see citing works
Afferent hyperexcitability in neuropathic pain and the inconvenient truth about its degeneracy
Ratté, S., & Prescott, S. A. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.08.007 · Cited by 78 · see citing works
Self-citationTashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki‐Saitoh, H., Fukazawa, Y., Inoue, K., et al. (2018) · eNeuro · doi:10.1523/eneuro.0450-17.2018 · Cited by 79 · see citing works
Microglia-Mediated Regulation of Neuropathic Pain: Molecular and Cellular Mechanisms
Tsuda, M. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00715 · Cited by 79 · see citing works
P2 receptors, microglial cytokines and chemokines, and neuropathic pain
Tsuda, M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23816 · Cited by 71 · see citing works
Ziegler, K., Folkard, R., Gonzalez, A. J., Burghardt, J., Antharvedi-Goda, S., Martín-Cortecero, J., Isaías-Camacho, E. U., Kaushalya, S. K., Tan, L. L., Kuner, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38798-7 · Cited by 71 · see citing works
Rate and timing of cortical responses driven by separate sensory channels
Saal, H. P., Harvey, M. A., & Bensmaı̈a, S. J. (2015) · eLife · doi:10.7554/elife.10450 · Cited by 63 · see citing works
How microglia contribute to the induction and maintenance of neuropathic pain
Malcangio, M., & Sideris-Lampretsas, G. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00914-5 · Cited by 66 · see citing works
Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain
Vasylyev, D. V., Zhao, P., Schulman, B. R. M., & Waxman, S. G. (2024) · The Journal of General Physiology · doi:10.1085/jgp.202413596 · Cited by 60 · see citing works
Synaptic Inhibition and Disinhibition in the Spinal Dorsal Horn
Prescott, S. A. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.11.008 · Cited by 60 · see citing works
Self-citationTime-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain
Yousefpour, N., Locke, S., Deamond, H., Wang, C., Marques, L., Louis, M. S., Ouellette, J., Khoutorsky, A., Koninck, Y. D., & Ribeiro‐da‐Silva, A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112010 · Cited by 66 · see citing works
Lee, K. Y., Ratté, S., & Prescott, S. A. (2019) · eLife · doi:10.7554/elife.49753 · Cited by 55 · see citing works
Self-citationTime-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses
Browne, L. E., Latrémolière, A., Lehnert, B. P., Grantham, A., Ward, C., Alexandre, C., Costigan, M., Michoud, F., Roberson, D. P., Ginty, D. D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.024 · Cited by 55 · see citing works
Epidural optogenetics for controlled analgesia
Bonin, R. P., Wang, F., Desrochers-Couture, M., Gąsecka, A., Boulanger, M.-E., Côté, D. C., & Koninck, Y. D. (2016) · Molecular Pain · doi:10.1177/1744806916629051 · Cited by 53 · see citing works
Graham, R., Bruns, T. M., Duan, B., & Lempka, S. F. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.02.016 · Cited by 53 · see citing works
The neural circuits of thermal perception
Bokiniec, P., Zampieri, N., Lewin, G. R., & Poulet, J. F. A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.04.006 · Cited by 52 · see citing works
Brain Imaging Biomarkers for Chronic Pain
Zhang, Z., Gewandter, J. S., & Geha, P. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.734821 · Cited by 53 · see citing works
A novel spinal neuron connection for heat sensation
Wang, H., Chen, W., Dong, Z., Xing, G., Cui, W., Yao, L., Zou, W.-J., Robinson, H. L., Bian, Y., Liu, Z., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.021 · Cited by 53 · see citing works
Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways
Stachowski, N. J., & Dougherty, K. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052667 · Cited by 51 · see citing works
Novelty Manipulations, Memory Performance, and Predictive Coding: the Role of Unexpectedness
Reichardt, R., Polner, B., & Simor, P. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00152 · Cited by 48 · see citing works
Neuropathic pain; what we know and what we should do about it
Smith, P. A. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1220034 · Cited by 49 · see citing works
Sexual Dimorphism in the Mechanism of Pain Central Sensitization
Barcelon, E. E., Chung, S., Lee, J., & Lee, S. J. (2023) · Cells · doi:10.3390/cells12162028 · Cited by 48 · see citing works
Zhang, T. C., Janik, J. J., Peters, R. V., Chen, G., Ji, R., & Grill, W. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00147.2015 · Cited by 47 · see citing works
Khan, W. U., Michelini, G., & Battaglia, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.015 · Cited by 46 · see citing works
Medlock, L., Sekiguchi, K., Hong, S., Durá-Bernal, S., Lytton, W. W., & Prescott, S. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1199-21.2022 · Cited by 41 · see citing works
Self-citationLou, S., Pan, X., Huang, T., Duan, B., Yang, F.-C., Yang, J., Xiong, M., Liu, Y., & Ma, Q. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0122-15.2015 · Cited by 46 · see citing works
Self-citationSakai, A., & Suzuki, H. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_3 · Cited by 45 · see citing works
Biggs, J. E., Boakye, P. A., Ganesan, N., Stemkowski, P. L., Lantero, A., Ballanyi, K., & Smith, P. A. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00168.2014 · Cited by 42 · see citing works
Lee, K. Y., & Prescott, S. A. (2015) · Pain · doi:10.1097/j.pain.0000000000000301 · Cited by 41 · see citing works
Self-citationCircuit Mechanisms of Itch in the Brain
Mu, D., & Sun, Y.-G. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.09.022 · Cited by 40 · see citing works
BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended
Smith, P. A. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.02.020 · Cited by 38 · see citing works
Sullivan, S. J., & Sdrulla, A. D. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1860-21.2021 · Cited by 37 · see citing works
Prescott, S. A., & Ratté, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802381-5.00037-3 · Cited by 36 · see citing works
Self-citationInhibitory regulation of the pain gate and how its failure causes pathological pain
Price, T. J., & Prescott, S. A. (2015) · Pain · doi:10.1097/j.pain.0000000000000139 · Cited by 37 · see citing works
Self-citationGilbert, J. E., Titus, N. D., Zhang, T. C., Esteller, R., & Grill, W. M. (2022) · eNeuro · doi:10.1523/eneuro.0058-22.2022 · Cited by 36 · see citing works
Deciphering neuronal population codes for acute thermal pain
Chen, Z. S., Zhang, Q., Tong, A. P., Manders, T. R., & Wang, J. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa644d · Cited by 36 · see citing works
The characteristics of pain and dysesthesia in patients with diabetic polyneuropathy
Gylfadottir, S. S., Itani, M., Kristensen, A. G., Karlsson, P., Krøigård, T., Bennett, D., Tankişi, H., Andersen, N. T., Jensen, T. S., Sindrup, S. H., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263831 · Cited by 32 · see citing works
A cholinergic circuit that relieves pain despite opioid tolerance
Sullere, S., Kunczt, A., & McGehee, D. S. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.017 · Cited by 30 · see citing works
Bai, Y., Pacheco‐Barrios, K., Pacheco-Barrios, N. V., Liang, G., & Fregni, F. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00235-z · Cited by 31 · see citing works
Scaini, S., Davies, S., Francesco, S. D., Pelucchi, A., Rubino, S., & Battaglia, M. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106014 · Cited by 28 · see citing works
Organization of the Thermal Grill Illusion by Spinal Segments
Fardo, F., Finnerup, N. B., & Haggard, P. (2018) · Annals of Neurology · doi:10.1002/ana.25307 · Cited by 26 · see citing works
Reproducible and fully automated testing of nocifensive behavior in mice
Dedek, C., Azadgoleh, M. A., & Prescott, S. A. (2023) · Cell Reports Methods · doi:10.1016/j.crmeth.2023.100650 · Cited by 27 · see citing works
Self-citationAltered thermal grill response and paradoxical heat sensations after topical capsaicin application
Schaldemose, E. L., Horjales-Araújo, E., Svensson, P. J., & Finnerup, N. B. (2015) · Pain · doi:10.1097/j.pain.0000000000000155 · Cited by 27 · see citing works
Purinergic signalling in spinal pain processing
Tam, T. H., & Salter, M. W. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09748-5 · Cited by 27 · see citing works
Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord
Zhang, M., Kupari, J., Su, J., Magnusson, K. A., Hu, Y., Calvo-Enrique, L., Usoskin, D., Albisetti, G. W., Ceder, M. M., Henriksson, K., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01921-6 · Cited by 27 · see citing works
Quantitative sensory testing of temperature thresholds: Possible biomarkers for persistent pain?
Malmström, E.-M., Stjerna, J., Högestätt, E., & Westergren, H. (2016) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-2024 · Cited by 25 · see citing works
Differential modification of ascending spinal outputs in acute and chronic pain states
Yarmolinsky, D. A., Zeng, X., MacKinnon-Booth, N., Greene, C. A., Kim, C., Cheng, Y., Turnes, B. L., & Woolf, C. J. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.031 · Cited by 24 · see citing works
Probing pain pathways with light
Wang, F., Bélanger, E., Paquet, M.-È., Côté, D. C., & Koninck, Y. D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.035 · Cited by 25 · see citing works
Mechanisms Underlying Bone and Joint Pain
Havelin, J., & King, T. E. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0493-1 · Cited by 24 · see citing works
Nierula, B., Stephani, T., Bailey, E., Kaptan, M., Pohle, L.-M. G., Horn, U., Mouraux, A., Maeß, B., Villringer, A., Curio, G., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002828 · Cited by 23 · see citing works
Benarroch, E. E. (2016) · Neurology · doi:10.1212/wnl.0000000000002478 · Cited by 23 · see citing works
Novel treatments for chronic pain: moving beyond opioids
O’Brien, J. B., & Roman, D. L. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.008 · Cited by 21 · see citing works
Bladder infection with uropathogenic Escherichia coli increases the excitability of afferent neurons
Montalbetti, N., Dalghi, M. G., Bastacky, S., Clayton, D. R., Ruiz, W. G., Apodaca, G. L., & Carattino, M. D. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00167.2021 · Cited by 21 · see citing works
The structure of sensory afferent compartments in health and disease
Middleton, S. J., Pérez-Sánchez, J., & Dawes, J. M. (2021) · Journal of Anatomy · doi:10.1111/joa.13544 · Cited by 19 · see citing works
The Known Biology of Neuropathic Pain and Its Relevance to Pain Management
Smith, P. A. (2023) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2023.10 · Cited by 20 · see citing works
Astrocytes in the spinal dorsal horn and chronic itch
Tsuda, M. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.08.010 · Cited by 20 · see citing works
CT Afferent-Mediated Affective Touch: Brain Networks and Functional Hypotheses
Morrison, I. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6418-5_12 · Cited by 18 · see citing works
Zell, V., Juif, P., Hanesch, U., Poisbeau, P., Anton, F., & Darbon, P. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12796 · Cited by 19 · see citing works
The impact of bone cancer on the peripheral encoding of mechanical pressure stimuli
Kucharczyk, M. W., Chisholm, K. I., Denk, F., Dickenson, A. H., Bannister, K., & McMahon, S. B. (2020) · Pain · doi:10.1097/j.pain.0000000000001880 · Cited by 19 · see citing works
Glannon, W. (2018) · doi:10.1093/med/9780198758853.001.0001 · Cited by 29 · see citing works
New approach for investigating neuropathic allodynia by optogenetics
Tsuda, M. (2019) · Pain · doi:10.1097/j.pain.0000000000001506 · Cited by 18 · see citing works
Schorscher-Petcu, A., Takács, F., & Browne, L. E. (2021) · eLife · doi:10.7554/elife.62026 · Cited by 17 · see citing works
He, J. G., Wang, H., Huang, J., Zhang, L., Li, D., He, W., Xiong, Q. P., & Qin, Z. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10207 · Cited by 17 · see citing works
Gilbert, J. E., Zhang, T. C., Esteller, R., & Grill, W. M. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00186.2023 · Cited by 16 · see citing works
Stötzner, P., Spahn, V., Celik, M. Ö., Łabuz, D., & Machelska, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01478 · Cited by 17 · see citing works
- Authors
- Prescott, S. A., Ma, Q., & De Koninck, Y.
- Affiliations
- University of Toronto (CA)
- Harvard University (US)
- Corresponding author
- Prescott, Steven A
- Venue
- Nature Neuroscience
- Published
- 2014-01-28
- Volume
- 17
- Issue
- 2
- Pages
- 183-191
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4079041
- OpenAlex
- W2028575493
- Cited by
- 210
- References
- 106
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 18 · 2020: 10 · 2019: 10 · 2018: 31 · 2017: 14 · 2016: 24 · 2015: 21 · 2014: 7
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Canadian Institutes of Health Research (MOP12942)
- National Institute of Neurological Disorders and Stroke (P01NS072040, R01NS086372, R01NS047710, R21NS074146, R01NS076706, P01 NS0272040)
- National Institute of Dental and Craniofacial Research (R01DE018025)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain, somatosensory afferents, neural coding, noxious stimuli, labeled lines, pain perception, pain modulation, pain therapeutics
- MeSH terms
- Afferent Pathways, Animals, Humans, Models, Biological, Nociceptors, Pain, Perception, Physical Stimulation
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