The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytotoxicity of Biologically Synthesized Silver Nanoparticles in MDA-MB-231 Human Breast Cancer Cells
Open accessAbstract
Silver nanoparticles (AgNPs) have been used as an antimicrobial and disinfectant agents. However, there is limited information about antitumor potential. Therefore, this study focused on determining cytotoxic effects of AgNPs on MDA-MB-231 breast cancer cells and its mechanism of cell death. Herein, we developed a green method for synthesis of AgNPs using culture supernatant of Bacillus funiculus, and synthesized AgNPs were characterized by various analytical techniques such as UV-visible spectrophotometer, particle size analyzer, and transmission electron microscopy (TEM). The toxicity was evaluated using cell viability, metabolic activity, and oxidative stress. MDA-MB-231 breast cancer cells were treated with various concentrations of AgNPs (5 to 25 μ g/mL) for 24 h. We found that AgNPs inhibited the growth in a dose-dependent manner using MTT assay. AgNPs showed dose-dependent cytotoxicity against MDA-MB-231 cells through activation of the lactate dehydrogenase (LDH), caspase-3, reactive oxygen species (ROS) generation, eventually leading to induction of apoptosis which was further confirmed through resulting nuclear fragmentation. The present results showed that AgNPs might be a potential alternative agent for human breast cancer therapy.
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Cites
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., et al. (1995) · Science · doi:10.1126/science.270.5241.1491 · Cited by 1,964
Cited by
Rónavári, A., Igaz, N., Adamecz, D. I., Szerencsés, B., Molnar, C., Kónya, Z., Pfeiffer, I., & Kiricsi, M. (2021) · Molecules · doi:10.3390/molecules26040844 · Cited by 361
Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model
Zhang, X.-F., Shen, W., & Gurunathan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101603 · Cited by 308
Self-citationStrategic role of selected noble metal nanoparticles in medicine
Rai, M., Ingle, A. P., Birla, S., Yadav, A., & Santos, C. A. D. (2015) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1018131 · Cited by 290
Singh, R., Swanner, J., Mims, J., Akman, S., Furdui, C., Torti, S., & Carroll, D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s80349 · Cited by 130
Metadata
- Authors
- Gurunathan, S., Han, J. W., Eppakayala, V., Jeyaraj, M., & Kim, J.-H.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-10
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2164393253
- Cited by
- 390
- References
- 1
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gurunathan, S., Han, J. W., Eppakayala, V., Jeyaraj, M., & Kim, J.-H. (2013). Cytotoxicity of Biologically Synthesized Silver Nanoparticles in MDA-MB-231 Human Breast Cancer Cells. BioMed Research International. https://doi.org/10.1155/2013/535796
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