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Cited by 25Bariatric Surgery and OutcomesLiver Disease Diagnosis and TreatmentMinimally Invasive Surgical Techniques

Platelet Counts and Liver Enzymes after Bariatric Surgery

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Johansson, Hans-Erik, Haenni, Arvo, Zethelius, Björn·2013·Journal of Obesity
DOI 10.1155/2013/567984PMC PMC3590647
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Abstract

Background. Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are associated with inflammatory conditions and are a valuable biomarker of the degree of fibrosis in NAFLD. We investigated alterations in PC, GGT, and ALT after biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP).Methods. Ten morbidly obese patients (body mass index, BMI:53.5±3.8 kg/m 2) who underwent BPD-DS were evaluated preoperatively (baseline) and 1 year (1st followup) and 3 years (2nd followup) after surgery and compared with 21 morbidly obese patients (BMI:42.3±5.2 kg/m 2) who underwent RYGBP.Results. Over the 3 years of followup, changes in BPD-DS and RYGBP patients (BPD-DS/RYGBP) were as follows: BMI (−44%/−24%), GGT (−63%/−52%), and ALT (−48%/−62%). PC decreased (−21%) statistically significantly only in BPD-DS patients.Conclusions. Morbidly obese patients treated by RYGBP or BPD-DS show sustained reductions in BMI, ALT, and GGT. The decrease in PC and liver enzymes after BPD-DS may reflect a more pronounced decrease of liver-fat-content-related inflammation and, as a result, a lowered secondary thrombocytosis.

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Authors
Johansson, H.-E., Haenni, A., & Zethelius, B.
Affiliations
Uppsala University (SE)
Corresponding author
Johansson, Hans-Erik
ORCID
Venue
Journal of Obesity
Publisher
Hindawi Limited
Published
2013
Volume
2013
Pages
1-5
ISSN
  • 2090-0708 (ISSN-L)
  • 2090-0716
DOI
10.1155/2013/567984
PMC
PMC3590647
OpenAlex
W2083726700
Cited by
25
References
2
Citations by year
2025: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2
FWCI
1.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Obesity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Thureus Fund
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
Keywords
platelet count, liver enzymes, gamma-glutamyl transferase, alanine aminotransferase, bariatric surgery, biliopancreatic diversion with duodenal switch, Roux-en-Y gastric bypass, morbid obesity, non-alcoholic fatty liver disease, hepatic steatosis, secondary thrombocytosis, liver inflammation, weight loss
MeSH terms
Adult, Alanine Transaminase, Fatty Liver, Female, gamma-Glutamyltransferase, Humans, Inflammation, Liver, Male, Middle Aged, Obesity, Morbid, Platelet Count, Gastric Bypass, Weight Loss, Biliopancreatic Diversion, Body Mass Index, Bariatric Surgery, Non-alcoholic Fatty Liver Disease

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