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Cited by 172Advanced Neuroimaging Techniques and ApplicationsMultiple Sclerosis Research StudiesAdvanced MRI Techniques and Applications

DTI Measurements in Multiple Sclerosis: Evaluation of Brain Damage and Clinical Implications

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Sbardella, Emilia, Tona, Francesca, Petsas, Nikolaos, Pantano, Patrizia·2013·Multiple Sclerosis International
DOI 10.1155/2013/671730PMC PMC3628664
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Abstract

Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded noteworthy results. DTI abnormalities, which are already detectable in patients with clinically isolated syndrome (CIS), become more pronounced as disease duration and neurological impairment increase. The assessment of the microstructural alterations of white and grey matter in MS may shed light on mechanisms responsible for irreversible disability accumulation. In this paper, we examine the DTI analysis methods, the results obtained in the various tissues of the central nervous system, and correlations with clinical features and other MRI parameters. The adoption of DTI metrics to assess the outcome of prognostic measures may represent an extremely important step forward in the MS research field.

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  • Clinical studies frequently employ advanced tractography methods to reconstruct individual tract streamlines and obtain feasible results even when brain lesions are present.

    “clinical studies frequently employ advanced tractography methods to reconstruct individual tract streamlines (Sbardella et al., 2013) and obtain feasible results even when brain lesions are present (Lipp et al., 2020).”

    From Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review (2022) · cites this paper as Sbardella et al., 2013

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Cited by

Sorted by citations

Authors
Sbardella, E., Tona, F., Petsas, N., & Pantano, P.
Affiliations
  • Sapienza University of Rome (IT)
  • Department of Neurology and Psychiatry, Sapienza University, Viale dell’Università 30, 00185 Rome, Italy
Corresponding author
Sbardella, Emilia
ORCID
Venue
Multiple Sclerosis International
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-11
ISSN
  • 2090-2654 (ISSN-L)
  • 2090-2662
DOI
10.1155/2013/671730
PMC
PMC3628664
OpenAlex
W2069218189
Cited by
172
References
6
Citations by year
2026: 6 · 2025: 14 · 2024: 9 · 2023: 11 · 2022: 18 · 2021: 11 · 2020: 13 · 2019: 18 · 2018: 17 · 2017: 13 · 2016: 17 · 2015: 10 · 2014: 12 · 2013: 2 · 2012: 1
FWCI
10.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Multiple Sclerosis International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
multiple sclerosis, diffusion tensor imaging, demyelination, axonal loss, clinically isolated syndrome, white matter microstructure, grey matter, disability progression, prognostic factors, MRI parameters

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