Expression level of IL-6 secreted by bone marrow stromal cells in mice with aplastic anemia
Open accessAbstract
Parasecretion of the hematopoietic cytokines is considered as one of the mechanisms account for bone marrow hematopoiesis disorder. In this study, the level of IL-6 secreted by bone marrow stromal cells from a mouse model of aplastic anemia was analyzed. The aplastic anemia mouse model was established with cyclophosphamide in combination with chloramphenicol and (60)Co γ radiation. The impairment of bone marrow hematopoiesis induced by irradiation and chemotherapeutic drugs was subsequently characterized by peripheral blood cell count, pathomorphological changes, and apoptosis rate. Furthermore, the in vitro proliferation of bone marrow stromal cells (BMSC) and the IL-6 secretion levels of BMSC were analyzed. In our model of aplastic anemia, the number of peripheral blood cells and bone marrow cells (BMC) were notably decreased, and the apoptosis rate of BMC increased. Furthermore, the proliferation of BMSC was obviously impeded while the IL-6 secretion levels of BMSC significantly increased. The findings of our study suggested that the IL-6 secretion level may be enhanced to some extent by the induction of aplastic anemia caused by irradiation and chemotherapeutic drugs and that the abnormal level of IL-6 might probably interfere with the stability of the bone marrow hematopoietic microenvironment.
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Indirect effects of IFN-g on macrophages and MSCs contribute to high levels of accessory inflammatory cytokines like IL-6, IL-1b, and TNF-a.
“Indirect effects of IFN-g on macrophages and MSCs have been implied to contribute to high levels of accessory inflammatory cytokines like IL-6, IL-1b, and TNF-a.57”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [57]
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- Authors
- Chen, Y. F., Wu, Z. M., Xie, C., Bai, S., & Zhao, L. D.
- Affiliations
- Taizhou University (CN)
- Corresponding author
- Chen, Yong Feng
- Venue
- ISRN Hematology
- Publisher
- Hindawi Limited
- Published
- 2013-06-18
- Volume
- 2013
- Pages
- 1-6
- ISSN
- 2090-441X (ISSN-L)
- 2090-4428
- PMC
- PMC3703356
- OpenAlex
- W2156670244
- Cited by
- 21
- References
- 20
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2019: 4 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- ISRN Hematology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Zhejiang Provincial Natural Science Foundation of China (LY12C05002)
- Research Foundation of the Science and Technology Bureau of TaiZhou (LY12C05002)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Keywords
- interleukin-6, mesenchymal stem cells, aplastic anemia, hematopoiesis, cyclophosphamide, chloramphenicol, cobalt-60 irradiation, apoptosis, cell proliferation, hematopoietic growth factors
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