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Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar A β1–42to the Rat Brain
Open accessAbstract
Several animal models of Alzheimer’s disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fA β) peptide represents one of the most frequently used models, mimicking A β deposits in the brain. In our experiment synthetic fA β1–42 peptide was administered to rat hippocampus. The effect of the A β peptide on spatial memory and dendritic spine density was studied. The fA β1–42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fA β1–42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying A β-triggered neurodegeneration processes.
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Previous reports have detected a reduction in synaptic spines after injections of fibrillar Aβ42 in rat brain.
“Previous reports have looked at the effect of injections of fibrillar Aβ42 in rat brain and detected a reduction in synaptic spines [40]”
From Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease (2021) · cites this paper as [40]
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Davis, N., Mota, B. C., Stead, L., Palmer, E. O. C., Lombardero, L., Rodríguez-Puertas, R., de Paola, V., Barnes, S. J., & Sastre, M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02117-y · Cited by 65
Metadata
- Authors
- Borbély, E., Horváth, J., Furdan, S., Bozsó, Z., Penke, B., & Fülöp, L.
- Affiliations
- University of Szeged (HU)
- Corresponding author
- Fülöp, Lívia
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-9
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4094878
- OpenAlex
- W2069906799
- Cited by
- 21
- References
- 11
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Union Seventh Framework Programme Food (211696, 4.2.2/A-11/1/KONV-2012-0052)
- Hungarian research Grant TÁMOP (211696, 4.2.2/A-11/1/KONV-2012-0052)
- National Natural Science Foundation of China (211696, 4.2.2/A-11/1/KONV-2012-0052)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amyloid-beta 42, fibrillar amyloid-beta, Alzheimer's disease model, intrahippocampal injection, spatial memory, spatial learning, dendritic spine density, hippocampal CA1, neurodegeneration, Morris water maze
- MeSH terms
- Amyloid, Animals, Golgi Apparatus, Hippocampus, Male, Peptide Fragments, Amyloid beta-Peptides, Rats, Wistar, Pyramidal Cells, Maze Learning, Dendritic Spines, CA1 Region, Hippocampal, Spatial Memory
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