The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging
Open accessAbstract
The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with (OLSv= RP-loaded opaque liquid system andTLSv= RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied. Samples were characterized using polarized light microscopy (PLM) and rheology analysis.In vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays.In vitro antioxidant activity was performed by the DPPH method. PLM analysis showed the presence of lamellar LCS just to TLS. Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations. The results showed that the incorporation of RP in LCS improved the safety profile of the drug.In vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP. PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging.
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“Retinyl palmitate can be compounded with photostabilizers and UV filters and loaded onto nanotechnology-based drug-delivery systems to improve stability and drug penetration”
From Sunscreens and Photoaging: A Review of Current Literature (2021) · cites this paper as [72]
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Cites
Antioxidant Determinations by the Use of a Stable Free Radical
BLOIS, M. S. (1958) · Nature · doi:10.1038/1811199a0 · Cited by 12,994
Drug Development and Industrial Pharmacy
Rhodes, C. T. (1995) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049509070870 · Cited by 1,258
UV-light-induced signal cascades and skin aging
Rittié, L., & Gary Fisher, J. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00024-7 · Cited by 1,011
Nanotechnology-based drug delivery systems and herbal medicines: a review
Silva, P., Bonifácio, B., Ramos, M., Negri, K., Maria Bauab, T., & Chorilli, M. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s52634 · Cited by 678
Self-citationInfluence of microemulsions on cutaneous drug delivery
Kreilgaard, M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00116-3 · Cited by 629
Overview of skin aging and photoaging.
Helfrich, Y. R., Sachs, D. L., & Voorhees, J. J. (2008) · PubMed · Cited by 259
Antioxidants and vitamins in cosmetics
Lupo, M. P. (2001) · Clinics in Dermatology · doi:10.1016/s0738-081x(01)00188-2 · Cited by 239
Huang, Z.-R., Hua, S.-C., Yang, Y.-L., & Fang, J. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00829.x · Cited by 201
Rheological, mechanical, and bioadhesive behavior of hydrogels to optimize skin delivery systems
Carvalho, F. C., Calixto, G. M. F., Hatakeyama, I. N., da Luz, G. M., Gremião, M. P. D., & Chorilli, M. (2012) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2012.734510 · Cited by 186
Self-citationRheological behavior and the SPF of sunscreens
Gaspar, L. R., & Campos, P. M. B. G. M. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00462-3 · Cited by 172
Research works printed but not linked: 9
- 2008, Dermatology Nursing, 20, 177
- 2005, Revista Brasileira de Ciências Farmacêuticas, 41, 301
- 2007, Brazilian Journal of Pharmaceutical Sciences, 43
- 2011, Visão Acadêmica, 11
- 2003, Cosmetics and Toiletries, 118, 41
- 2003, Cosmetics & Toiletries, 15, 96
- 2013, Journal of Applied Pharmaceutical Science, 3, 1
- 10.1691/ph.2009.8232 · DOI
- 2014, Journal of Nanoscience and Nanotechnology, 14, 1, 10.1166/jnn.2014.9265 · DOI
Cited by
Sunscreens and Photoaging: A Review of Current Literature
Guan, L. L., Lim, H. W., & Mohammad, T. F. (2021) · American Journal of Clinical Dermatology · doi:10.1007/s40257-021-00632-5 · Cited by 313
Metadata
- Authors
- Oliveira, M. B., Prado, A. H. D., Bernegossi, J., Sato, C. S., Lourenço Brunetti, I., Scarpa, M. V., Leonardi, G. R., Friberg, S. E., & Chorilli, M.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Departament of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, UNESP, 14801-902 Araraquara, SP, Brazil
- Departament of Clinical Analysis, School of Pharmaceutical Sciences, UNESP, 14801-902 Araraquara, SP, Brazil, Brazil
- Universidade Federal de São Paulo (BR)
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Chorilli, Marlus
- ORCID
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-7
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3977527
- OpenAlex
- W1977124446
- Cited by
- 49
- References
- 37
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 3
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Programa de Apoio ao Desenvolvimento Científico
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- retinyl palmitate, skin aging, liquid crystalline systems, topical drug delivery, lamellar phase, rheological properties, shear thinning, cytotoxicity, hemolysis, antioxidant activity, nanotechnology-based drug delivery
- MeSH terms
- Retinyl Esters, Administration, Topical, Diterpenes, Drug Evaluation, Preclinical, Humans, Vitamin A, Skin Aging, Drug Delivery Systems, Nanotechnology
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
