The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Th17 Cells in Autoimmune and Infectious Diseases
Open accessAbstract
The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388
Functional Specialization of Interleukin-17 Family Members
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Interleukin 21: a cytokine/cytokine receptor system that has come of age
Leonard, W. J., Zeng, R., & Spolski, R. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0308149 · Cited by 122
IL-17RC: a partner in IL-17 signaling and beyond
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Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267
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Metadata
- Authors
- Zambrano-Zaragoza, J. F., Romo-Martínez, E. J., Durán-Avelar, M. D. J., García-Magallanes, N., & Vibanco-Pérez, N.
- Venue
- International Journal of Inflammation
- Publisher
- Hindawi Limited
- Published
- 2014
- Volume
- 2014
- Pages
- 1-12
- ISSN
- 2042-0099 (ISSN-L)
- 2090-8040
- OpenAlex
- W2161850401
- Cited by
- 209
- References
- 8
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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