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Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report
Abstract
Central pontine myelinolysis is a demyelinating disorder characterized by the loss of myelin in the center of the basis pontis usually caused by rapid correction of chronic hyponatremia. The clinical features vary depending on the extent of involvement. Demyelination can occur outside the pons as well and diagnosis can be challenging if both pontine and extrapontine areas are involved. We herein report a case of myelinolysis involving pons, lateral geniculate bodies, subependymal region, and spinal cord. To the best of our knowledge, this case represents the second case of spinal cord involvement in osmotic demyelination syndrome and the first case of involvement of thoracic region of spinal cord.
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“In CPM, characteristic MRI findings include symmetric, T2-weighted hyperintense and T1-weighted hypointense lesions located centrally within the pons.”
From Pediatric osmotic demyelination syndrome triggered by post-traumatic pituitary stalk injury: a case report (2026) · cites this paper as [18]
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Research works printed but not linked: 13
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- 1959, AMA Archives of Neurology & Psychiatry, 81, 154, 10.1001/archneurpsyc.1959.02340140020004 · DOI · Paper page
- 1987, Clinical Neuropathology, 6, 262
- 1987, Annals of Internal Medicine, 107, 656, 10.7326/0003-4819-107-5-656 · DOI · Paper page
- 1994, Journal of the American Society of Nephrology, 4, 1522, 10.1681/ASN.V481522 · doi:10.1681/asn.v481522
- 10.1016/j.amjmed.2007.09.001 · DOI · Paper page
- 10.1002/ana.410270110 · doi:10.1002/ana.410270110
- 2004, The American Journal of Neuroradiology, 25, 210
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- 2012, Frontiers in Neurology, 3
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Cited by
Sheng, M., Zhang, M., & Lu, W. (2026) · BMC Pediatrics · doi:10.1186/s12887-026-07049-1
Metadata
- Authors
- Jacob, S., Gupta, H., Nikolic, D., Gundogdu, B., & Ong, S.
- Affiliations
- Department of Neurology, Vanderbilt University, Nashville, TN, USA
- Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
- Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
- ORCID
- Gupta, Harsh
- Venue
- Case Reports in Neurological Medicine
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-5
- ISSN
- 2090-6668
- 2090-6676
- Cited by
- 4
- References
- 0
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
