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Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy
Open accessAbstract
Skeletal muscle inflammation and atrophy are closely associated with metabolic impairment such as insulin resistance. Quercetin, a natural polyphenol flavonoid, is known to elicit anti-inflammatory and antioxidant activities. In this study, we investigated its effect on obesity-induced skeletal muscle inflammation and atrophy in mice. Male C57BL/6 mice were fed a regular diet, a high-fat diet (HFD), and an HFD supplemented with quercetin for nine weeks. Quercetin reduced levels of inflammatory cytokines and macrophage accumulation in the skeletal muscle of the HFD-fed obese mice. It also reduced transcript and protein levels of the specific atrophic factors, Atrogin-1 and MuRF1, in the skeletal muscle of the HFD-fed obese mice, and protected against the reduction of muscle mass and muscle fiber size. In vitro, quercetin markedly diminished transcript levels of inflammatory receptors and activation of their signaling molecules (ERK, p38 MAPK, and NF-κB) in cocultured myotubes/macrophages, and this was accompanied by reduced expression of the atrophic factors. Together, these findings suggest that quercetin reduces obesity-induced skeletal muscle atrophy by inhibiting inflammatory receptors and their signaling pathway. Quercetin may be useful for preventing obesity-induced muscle inflammation and sarcopenia.
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“It is reported that quercetin could counteract the HFD-induced obesity in C57BL/6J mice [123].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [123]
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“Dietary supplementation with quercetin (3,3′,4′,5,7-pentahydroxyflavone), a natural flavonoid mainly present in apples, buckwheat, onions, and citrus fruits, protects against HFD-induced skeletal muscle inflammation and atrophy in C57BL/6 mice by inhibiting the expression of TNF-α, monocyte chemoattractant protein 1, MAFbx, and MuRF1 [123].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [123]
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Metadata
- Authors
- Le, N. H., Kim, C.-S., Park, T., Park, J. H. Y., Sung, M.-K., Lee, D. G., Hong, S.-M., Choe, S.-Y., Goto, T., Kawada, T., & Yu, R.
- Affiliations
- Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Republic of Korea
- University of Ulsan (KR)
- Yonsei University (KR)
- Hallym University (KR)
- Sookmyung Women's University (KR)
- Kyungpook National University (KR)
- Kyoto University (JP)
- Corresponding author
- Yu, Rina
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-10
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC4295595
- OpenAlex
- W2159198268
- Cited by
- 167
- References
- 41
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 20 · 2020: 10 · 2019: 19 · 2018: 12 · 2017: 11 · 2016: 9 · 2015: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (2012R1A2A4A01002702)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- quercetin, obesity, skeletal muscle atrophy, muscle inflammation, sarcopenia, high-fat diet, inflammatory cytokines, macrophage accumulation, atrogin-1, MuRF1, NF-κB signaling, MAPK signaling, myotubes, flavonoids, insulin resistance
- MeSH terms
- Tripartite Motif Proteins, Animals, Antioxidants, Atrophy, Base Sequence, Cell Line, Inflammation, Insulin Resistance, Macrophages, Male, Mice, Inbred C57BL, Muscle Proteins, Obesity, Quercetin, Signal Transduction, Cytokines, Muscle, Skeletal, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Mice, Sarcopenia
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