The history of toll-like receptors - redefining innate immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

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A Toll-like receptor recognizes bacterial DNA

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

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Function and Activation of NF-kappaB in the Immune System

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The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works

Approaching the asymptote? Evolution and revolution in immunology.Preprint

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Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

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The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

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Unresponsiveness of MyD88-deficient mice to endotoxin.

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Interleukin-1 and interleukin-1 antagonism

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

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A family of human receptors structurally related to Drosophila Toll.

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Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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Recognition of single-stranded RNA viruses by Toll-like receptor 7

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

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Structure and Function of Lipopolysaccharide Binding Protein

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The roles of TLRs, RLRs and NLRs in pathogen recognition

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Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )

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Oncogenically active MYD88 mutations in human lymphoma

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Sequence and specificity of two antibacterial proteins involved in insect immunity

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TLR9 signals after translocating from the ER to CpG DNA in the lysosome

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Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S., Lee, H., & Lee, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.008 · Cited by 1,352 · see citing works

The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor

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Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R. L., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.10 · Cited by 1,328 · see citing works

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

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Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

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Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6668 · Cited by 1,227 · see citing works

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,208 · see citing works

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

Lund, J. M., Sato, A., Akira, S., Medzhitov, R. M., & Iwasaki, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030162 · Cited by 1,197 · see citing works

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

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IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

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TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

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Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

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Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Mühlradt, P. F., Sato, S., Hoshino, K., & Akira, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5887 · Cited by 1,095 · see citing works

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

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TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., & Akira, S. (2003) · Nature Immunology · doi:10.1038/ni986 · Cited by 1,052 · see citing works

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

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Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

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A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

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TIRAP: an adapter molecule in the Toll signaling pathway

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Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

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cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

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Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

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Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

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Control of B-cell responses by Toll-like receptors

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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

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TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

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Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

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Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product

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dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

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Soluble CD14 participates in the response of cells to lipopolysaccharide.

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Drosophila Toll and IL-1 receptor

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Chemische Erforschung von Lipopolysacchariden gramnegativer Bakterien

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Structural Basis of TLR5-Flagellin Recognition and Signaling

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Structures of the Toll-like Receptor Family and Its Ligand Complexes

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Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum.

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The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling

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Recognition and plasma clearance of endotoxin by scavenger receptors

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Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8

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Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells

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Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

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Dif, a dorsal-related gene that mediates an immune response in Drosophila

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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

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Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

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Toll-like Receptors in the Vascular System: Sensing the Dangers Within

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Endothelial cells translate pathogen signals into G-CSF–driven emergency granulopoiesis

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Radiation and Inflammation

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Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

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Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

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Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk

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Gut microbiota and metabolic syndrome

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Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later

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RIP kinases: key decision makers in cell death and innate immunity

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Sweeten PAMPs: Role of sugar complexed PAMPs in innate immunity and vaccine biology

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TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes

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Innate immune sensing of coronavirus and viral evasion strategies

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TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

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TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

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Innate immune recognition of DNA: A recent history

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Obesity, diabetes, and the gut microbiome: an updated review

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Tomato receptor FLAGELLIN-SENSING 3 binds flgII-28 and activates the plant immune system

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Toll-like receptors and their role in persistent pain

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Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

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The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging

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TLR‐mediated activation of NK cells and their role in bacterial/viral immune responses in mammals

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Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism

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Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

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Mechanisms of Fever Production and Lysis: Lessons from Experimental LPS Fever

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Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

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Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants

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A guide to miRNAs in inflammation and innate immune responses

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Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

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Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

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Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression

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Anti-tumor Activity of Toll-Like Receptor 7 Agonists

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ERK1/2 in immune signalling

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Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950

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A dual-action peptide-containing hydrogel targets wound infection and inflammation

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Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns

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NF-κB: master regulator of cellular responses in health and disease

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MicroRNA as Type I Interferon-Regulated Transcripts and Modulators of the Innate Immune Response

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The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract

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Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy

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Nickel oxide nanoparticles induce inflammation and genotoxic effect in lung epithelial cells

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How the Innate Immune System Senses Trouble and Causes Trouble

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Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

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Exercise protects from cancer through regulation of immune function and inflammation

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The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules

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Nanoscale Metal–Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy

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Innate immunity's path to the N obel P rize 2011 and beyond

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Innate immunity and the 2011 Nobel Prize

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Of Flies and Men—The Discovery of TLRs

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Nagroda Nobla 2011: dwa rodzaje odporności

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2011 Nobel Prize in Physiology or Medicine

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