Inhibitory effect of veterinary antibiotics on denitrification in groundwater: a microcosm approach
Open accessAbstract
Veterinary antibiotics in groundwater may affect natural microbial denitrification process. A microcosm study was conducted to evaluate the influence of sulfamethazine and chlortetracycline at different concentrations (0, 0.01, 0.1, and 1.0 mg/L) on nitrate reduction in groundwater under denitrifying condition. Decrease in nitrate removal and nitrite production was observed with the antibiotics. Maximum inhibition of nitrate removal was observed after seven days of incubation with 0.01 mg/L sulfamethazine (17.0%) and 1.0 mg/L chlortetracycline (15.4%). The nitrite production was inhibited with 1.0 mg/L sulfamethazine to 82.0% and chlortetracycline to 31.1%. The initial/final nitrate concentrations indicated that 0.01 mg/L sulfamethazine and 1.0 mg/L chlortetracycline were most effective in inhibiting activity of denitrifying bacteria in groundwater. After 12 days of incubation, the sulfamethazine biodegradation was observed whereas chlortetracycline was persistent. Sulfamethazine and chlortetracycline in groundwater could inhibit the growth and capability of naturally occurring denitrifying bacteria, thereby threatening nitrate pollution in groundwater.
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Low levels of common antibiotics contaminate groundwater and soil and can disrupt bacterial denitrification.
“Recent ecological findings show that even low levels of common antibiotics contaminate groundwater and soil and can disrupt bacterial denitrification[424–426]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [426]
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- Authors
- Ahmad, M., Vithanage, M., Kim, K., Cho, J.-S., Lee, Y. H., Joo, Y. K., Lee, S. S., & Ok, Y. S.
- Affiliations
- Kangwon National University (KR)
- Kunsan National University (KR)
- Sunchon National University (KR)
- Gyeongsangnam-do Agricultural Research and Extension Services (KR)
- Yonsei University (KR)
- Corresponding author
- Lee, Sang Soo
- Ok, Yong Sik
- ORCID
- Venue
- The Scientific World JOURNAL
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-7
- ISSN
- 1537-744X (ISSN-L)
- 2356-6140
- PMC
- PMC3976856
- OpenAlex
- W1980960106
- Cited by
- 57
- References
- 27
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 4
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Scientific World JOURNAL (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- Kangwon National University
- Ministry of Environment
- Korea Basic Science Institute
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Physical Sciences › Environmental Science › Pollution › Wastewater Treatment and Nitrogen Removal
- Physical Sciences › Environmental Science › Pollution › Pesticide and Herbicide Environmental Studies
- Keywords
- veterinary antibiotics, sulfamethazine, chlortetracycline, denitrification inhibition, groundwater nitrate removal, nitrite production, denitrifying bacteria, antibiotic biodegradation, antibiotic persistence, groundwater nitrate contamination
- MeSH terms
- Animals, Anti-Bacterial Agents, Biodegradation, Environmental, Humans, Nitrates, Nitrites, Oxidation-Reduction, Water Pollutants, Chemical, Denitrification, Groundwater
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