The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Amyotrophic Lateral Sclerosis: A Focus on Disease Progression
Open accessAbstract
Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases. However, the molecular targets that directly influence its aggressive nature remain unknown. What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives.
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Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1971 · Cited by 1,107
Petri, S., Kiaei, M., Damiano, M., Hiller, A., Wille, E., Manfredi, G., Calingasan, N. Y., Szeto, H. H., & Beal, M. F. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04018.x · Cited by 166
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Metadata
- Authors
- Calvo, A. C., Manzano, R., Mendonça, D. M. F., Muñoz, M. J., Zaragoza, P., & Osta, R.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-12
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W1991716304
- Cited by
- 403
- References
- 3
- FWCI
- 27.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Calvo, A. C., Manzano, R., Mendonça, D. M. F., Muñoz, M. J., Zaragoza, P., & Osta, R. (2014). Amyotrophic Lateral Sclerosis: A Focus on Disease Progression. BioMed Research International. https://doi.org/10.1155/2014/925101
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