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Lower Urinary Tract Symptoms Are Associated with Increased Risk of Dementia among the Elderly: A Nationwide Study
Open accessAbstract
Studies show a strong association between dementia and lower urinary tract symptoms (LUTS). The aim of this study was to investigate whether LUTS are a risk factor for cognitive impairment. We enrolled 50-year-old and older subjects with LUTS (LUTS[+]) (n=6801) and controls without LUTS (LUTS[−]) (n=20,403) from Taiwan’s National Health Insurance Research Database. LUTS, dementia, and other confounding factors are defined by International Classification of Diseases, Ninth Revision, Clinical Modification Codes. Participants were recruited from 2000 to 2004 and then followed up until death or the end of 2011. The outcome was the onset of dementia, which was assessed using Poisson regression analysis, Cox hazards models, and Kaplan-Meier survival curves. The incidence of dementia was significantly higher in the LUTS[+]group than in the LUTS[−]group (124.76 versus 77.59/1000 person-years). The increased risk of dementia related to LUTS remained significant after adjustment for potential confounders (adjusted hazard ratio (AHR): 1.61, 95% confidence interval (CI) 1.47–1.76,P<0.0001) and higher than that related to cerebrovascular disease (AHR: 1.43, 95% CI 1.26–1.61,P<0.0001). The outcome suggests the need for early screening and appropriate intervention to help prevent cognitive impairment of patients with LUTS.
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Lower urinary tract symptoms themselves have been linked to future dementia incidence and may be a symptom of early neurodegeneration.
“Lower urinary tract symptoms themselves have been linked to future dementia incidence and may be a symptom of early neurodegeneration.42 43”
From Anticholinergic drugs and risk of dementia: case-control study (2018) · cites this paper as [42]
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Anticholinergic drugs and risk of dementia: case-control study
Richardson, K., Fox, C., Maidment, I., Steel, N., Loke, Y. K., Arthur, A., Myint, P. K., Grossi, C. M., Mattishent, K., Bennett, K., et al. (2018) · BMJ · doi:10.1136/bmj.k1315 · Cited by 520
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Metadata
- Authors
- Chiang, C.-H., Wu, M.-P., Ho, C.-H., Weng, S.-F., Huang, C.-C., Hsieh, W.-T., Hsu, Y.-W., & Chen, P.-J.
- Affiliations
- Chi Mei Medical Center (TW)
- Corresponding author
- Chen, Ping-Jen
- ORCID
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-7
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4531168
- OpenAlex
- W1937811769
- Cited by
- 43
- References
- 1
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- lower urinary tract symptoms, dementia, cognitive impairment, older adults, dementia risk factors, cerebrovascular disease
- MeSH terms
- Aged, Aged, 80 and over, Cognition Disorders, Female, Humans, Male, Middle Aged, Urinary Tract, Dementia, Vascular, Incidence, Survival Rate, Disease-Free Survival
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