The Pathogenicity of Anti-β 2GP1-IgG Autoantibodies Depends on Fc Glycosylation
Open accessAbstract
To analyze the glycosylation of anti-β 2GP1, we investigated purified IgG from healthy children, patients with APS, and asymptomatic adult carriers of antiphospholipid antibodies. We observed that in the sera of healthy children and of patients with APS, IgG3 and IgG2 were predominant, respectively. The potentially protective anti-β 2GP1-IgM was lower in the sera of healthy children. Although anti-β 2GP1-associated C1q did not differ between children and patients with antiphospholipid syndrome, the associated C3c was significantly higher in the sera of healthy children. This indicates a more efficient clearance of anti-β 2GP1 immune complexes in the healthy children. This clearance is not accompanied by inflammation or coagulatory events. It is likely that the most important pathogenic factor of the anti-β 2GP1-IgG is related to the different glycosylation observed in healthy and diseased individuals. We detected a significantly higher sialylation of anti-β 2GP1-IgG isolated from the sera of healthy children and asymptomatic adults when compared with that of patients with clinically apparent antiphospholipid syndrome. Low sialylated IgG reportedly ameliorates inflammation and inflammation promotes hyposialylation. Thus, both reactions create a vicious circle that precipitates the pathology of the antiphospholipid syndrome including thrombus-formation. We conclude that the increased sialylation of anti-β 2GP1-IgG of sera of healthy individuals limits their pathogenicity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
APS is considered heterogeneous not only in aPL profile but also in disease manifestations and potentially in physiopathology.
“APS is considered heterogeneous not only in aPL profile but also in the disease manifestations and potentially in the physiopathology. 26”
From Single or triple positivity for antiphospholipid antibodies in “carriers” or symptomatic patients: Untangling the knot (2021) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203 · see citing works
Self-citationAnti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
Kaneko, Y., Nimmerjahn, F., & Ravetch, J. V. (2006) · Science · doi:10.1126/science.1129594 · Cited by 1,754 · see citing works
Self-citationMcNeil, H. P., Simpson, R. J., Chesterman, C. N., & Krilis, S. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4120 · Cited by 1,595 · see citing works
The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins
Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., & Dwek, R. A. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141702 · Cited by 1,308 · see citing works
Tao, M., & Morrison, S. L. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.8.2595 · Cited by 531 · see citing works
Glycosylation of Recombinant Antibody Therapeutics
Jefferis, R. (2005) · Biotechnology Progress · doi:10.1021/bp040016j · Cited by 526 · see citing works
Schousboe, I. (1985) · Blood · doi:10.1182/blood.v66.5.1086.1086 · Cited by 362 · see citing works
Fabio Fischetti, I., Durigutto, P., Pellis, V., Debeus, A., Macor, P., Bulla, R., Bossi, F., Ziller, F., Sblattero, D., Meroni, P. L., et al. (2005) · Blood · doi:10.1182/blood-2005-03-1319 · Cited by 352 · see citing works
Mimura, Y., Church, S., Ghirlando, R., Ashton, P., Dong, S.-C., Goodall, M., Lund, J., & Jefferis, R. (2000) · Molecular Immunology · doi:10.1016/s0161-5890(00)00105-x · Cited by 337 · see citing works
A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs
Anthony, R. M., & Ravetch, J. V. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9405-6 · Cited by 317 · see citing works
Complement deficiencies and systemic lupus erythematosus
Truedsson, L., Bengtsson, A. A., & Sturfelt, G. (2007) · Autoimmunity · doi:10.1080/08916930701510673 · Cited by 315 · see citing works
Blank, M., Krause, I., Fridkin, M., Keller, N., Kopolovic, J., Goldberg, I., Tobar, A., & Shoenfeld, Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci12337 · Cited by 303 · see citing works
Huhn, C., Selman, M. H. J., Ruhaak, L. R., Deelder, A. M., & Wuhrer, M. (2009) · PROTEOMICS · doi:10.1002/pmic.200800715 · Cited by 301 · see citing works
Selective IgG subclass deficiency: quantification and clinical relevance
Jefferis, R., & Kumararatne, D. S. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05339.x · Cited by 266 · see citing works
Kaneko, Y., Nimmerjahn, F., Madaio, M. P., & Ravetch, J. V. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051900 · Cited by 246 · see citing works
Self-citationComplement activation in patients with primary antiphospholipid syndrome
Oku, K., Atsumi, T., Bohgaki, M., Amengual, O., Kataoka, H., Horita, T., Yasuda, S., & Koike, T. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.090670 · Cited by 219 · see citing works
(2004) · PubMed · Cited by 218 · see citing works
Lund, J., Takahashi, N., Pound, J. D., Goodall, M. D., & Jefferis, R. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.11.4963 · Cited by 216 · see citing works
de Laat, B., Derksen, R. H. W. M., van Lummel, M., Pennings, M. T. T., & de Groot, P. G. (2005) · Blood · doi:10.1182/blood-2005-05-1943 · Cited by 208 · see citing works
Infectious origin of the antiphospholipid syndrome
Shoenfeld, Y., Blank, M., Cervera, R., Font, J., Raschi, E., & Meroni, P. L. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.045443 · Cited by 206 · see citing works
Immunoglobulin G–mediated Inflammatory Responses Develop Normally in Complement-deficient Mice
Sylvestre, D. L., Clynes, R., Ma, M., Warren, H. B., Carroll, M. C., & Ravetch, J. V. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2385 · Cited by 198 · see citing works
Gharavi, A. E., Pierangeli, S. S., Espinola, R. G., Liu, X., Colden‐Stanfield, M., & Harris, E. N. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10130 · Cited by 174 · see citing works
Glycosylation and the Complement System
Ritchie, G. E., Moffatt, B. E., Sim, R. B., Morgan, B. P., Dwek, R. A., & Rudd, P. M. (2002) · Chemical Reviews · doi:10.1021/cr990294a · Cited by 170 · see citing works
Shi, T., Giannakopoulos, B., Yan, X., Yu, P., Berndt, M. C., Andrews, R. K., Rivera, J., Iverson, G. M., Cockerill, K. A., Linnik, M. D., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21968 · Cited by 167 · see citing works
Meroni, P. L., Raschi, E., Camera, M., Testoni, C., Nicoletti, F., Tincani, A., Khamashta, M. A., Balestrieri, G., Tremoli, E., & Hess, D. C. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0412 · Cited by 163 · see citing works
Self-citationThe significance of autoantibodies against β2-glycoprotein I
de Groot, P. G., & Urbanus, R. T. (2012) · Blood · doi:10.1182/blood-2012-03-378646 · Cited by 146 · see citing works
Immunoglobulin Subclasses in Normal Children
Schur, P. H., Rosen, F. S., & Norman, M. E. (1979) · Pediatric Research · doi:10.1203/00006450-197903000-00010 · Cited by 146 · see citing works
George, J., Blank, M., Levy, Y. M., Meroni, P. L., Damianovich, M., Tincani, A., & Shoenfeld, Y. (1998) · Circulation · doi:10.1161/01.cir.97.9.900 · Cited by 143 · see citing works
Self-citationSerum IgG subclass concentrations in healthy adults: a study using monoclonal antisera.
French, M. A., & Harrison, G. (1984) · PubMed Central · Cited by 126 · see citing works
Seed, P. T., Parmar, K., Moore, G. W., Stuart‐Smith, S., Hunt, B. J., & Breen, K. A. (2012) · Thrombosis and Haemostasis · doi:10.1160/th11-08-0554 · Cited by 111 · see citing works
Avčin, T., Ambrožič, A., Kuhar, M., Kveder, T., & Rozman, B. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.5.565 · Cited by 104 · see citing works
The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo
Anthony, R. M., & Nimmerjahn, F. (2010) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e328342538f · Cited by 92 · see citing works
Self-citationAndréoli, L., Nalli, C., Motta, M., Norman, G. L., Shums, Z., Encabo, S., Binder, W. L., Nuzzo, M. D., Frassi, M., Lojacono, A., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.137281 · Cited by 92 · see citing works
Self-citationRole of infectious agents in systemic rheumatic diseases.
Amital, H., Govoni, M., Maya, R., Meroni, P. L., Ori, B., Shoenfeld, Y., Tincani, A., Trotta, F., Sarzi‐Puttini, P., & Atzeni, F. (2008) · PubMed · Cited by 88 · see citing works
Self-citationInfections and vaccines in the etiology of antiphospholipid syndrome
Cruz‐Tapias, P., Blank, M., Anaya, J., & Shoenfeld, Y. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32835448b8 · Cited by 87 · see citing works
Antiphospholipid syndrome: pathogenic mechanisms
Espinosa, G., Cervera, R., Font, J., & Shoenfeld, Y. (2003) · Autoimmunity Reviews · doi:10.1016/s1568-9972(02)00144-1 · Cited by 81 · see citing works
Anti-beta2-glycoprotein I antibodies in children with atopic dermatitis
Ambrožič, A. (2002) · International Immunology · doi:10.1093/intimm/dxf043 · Cited by 74 · see citing works
Forastiero, R. R., Martinuzzo, M. E., Maclouf, J., & Carreras, L. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614216 · Cited by 62 · see citing works
IgG2 subclass restriction of anti-β2 glycoprotein 1 antibodies in autoimmune patients
Arvieux, J., Roussel, B., Ponard, D., & Colomb, M. G. (1994) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1994.tb06529.x · Cited by 59 · see citing works
Motta, M., Chirico, G., Rebaioli, C. B., Faden, D., Lojacono, A., Allegri, F., Migliori, C., & Tincani, A. (2006) · American Journal of Perinatology · doi:10.1055/s-2006-939533 · Cited by 56 · see citing works
Self-citationPolymorphism in the Human Complement C4 Genes and Genetic Susceptibility to Autoimmune Hepatitis
Doherty, D. G., Underhill, J. A., Donaldson, P. T., Manabe, K., Mieli‐Vergani, G., Eddleston, A. L. W. F., Vergani, D., Demaine, A. G., & Williams, R. L. (1994) · Autoimmunity · doi:10.3109/08916939409009525 · Cited by 49 · see citing works
B cells are critical for autoimmune pathology in Scurfy mice
Aschermann, S., Lehmann, C. H. K., Mihai, S., Schett, G. A., Dudziak, D., & Nimmerjahn, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313547110 · Cited by 48 · see citing works
Self-citationAnti-Beta 2-Glycoprotein I Antibody Isotype and IgG Subclass in Antiphospholipid Syndrome Patients
Guerin, J., Casey, E., Feighery, C., & Jackson, J. (1999) · Autoimmunity · doi:10.3109/08916939908994054 · Cited by 43 · see citing works
Fischer, M. J., Rauch, J., & Levine, J. S. (2007) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2006.09.006 · Cited by 40 · see citing works
Antiphospholipid syndrome in children
Avčin, T. (2008) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283060a8c · Cited by 38 · see citing works
Infections and the Antiphospholipid Syndrome
García‐Carrasco, M., Galarza-Maldonado, C. M., Pinto, C. M., Escarcega, R. O., & Cervera, R. (2008) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-008-8103-0 · Cited by 37 · see citing works
Anti‐β2‐glycoprotein I antibodies
Willis, R., & Pierangeli, S. S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12080 · Cited by 34 · see citing works
Samarkos, M., Davies, K. A., Gordon, C., Walport, M. J., & Loizou, S. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.9.1026 · Cited by 33 · see citing works
Blank, M., Krause, I., Fridkin, M., Keller, N., Kopolovic, J., Goldberg, I., Tobar, A., & Shoenfeld, Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200212337 · Cited by 27 · see citing works
Palarasah, Y., Skjødt, K., Brandt, J., Teisner, B., Koch, C., Vitved, L., & Skjoedt, M. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.09.024 · Cited by 26 · see citing works
von Landenberg, P., Döring, Y., Modrow, S., & Lackner, K. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1422.060 · Cited by 17 · see citing works
Odorczuk, M., KEIL, L. B., & DeBari, V. A. (1999) · Inflammation Research · doi:10.1007/s000110050497 · Cited by 7 · see citing works
Antiphospholipid syndrome and antiphospholipid antibodies in children: the two sides of the coin.
Nalli, C., Piantoni, S., Andréoli, L., Motta, M., & Tincani, A. (2012) · PubMed · Cited by 5 · see citing works
Self-citationMechanism of Thrombosis in Antiphospholipid Syndrome: Binding to Platelets
Reverter, J. C., & Tàssies, D. (2006) · Springer eBooks · doi:10.1007/1-84628-009-5_32 · Cited by 3 · see citing works
Wilson (1999) · doi:10.1002/1529-0131(199907)42:7
Flagged first, then by citations
Cited by
Sorted by citations
Immunoglobulin G glycosylation in aging and diseases
Gudelj, I., Lauc, G., & Pezer, M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.07.009 · Cited by 405 · see citing works
Seeling, M., Brückner, C., & Nimmerjahn, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.146 · Cited by 179 · see citing works
Self-citationNovel Concepts of Altered Immunoglobulin G Galactosylation in Autoimmune Diseases
Dekkers, G., Rispens, T., & Vidarsson, G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00553 · Cited by 111 · see citing works
Glycobiology of rheumatic diseases
Kissel, T., Toes, R. E. M., Huizinga, T. W. J., & Wuhrer, M. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00867-4 · Cited by 102 · see citing works
Kemna, M. J., Plomp, R., van Paassen, P., Koeleman, C. A. M., Jansen, B. C., Damoiseaux, J. G. M. C., Tervaert, J. W. C., & Wuhrer, M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.033 · Cited by 97 · see citing works
Sweet but dangerous – the role of immunoglobulin G glycosylation in autoimmunity and inflammation
Biermann, M. H. C., Griffante, G., Podolska, M. J., Boeltz, S., Stürmer, J., Munoz, L. E., Bilyy, R. O., & i, M. H. (2016) · Lupus · doi:10.1177/0961203316640368 · Cited by 85 · see citing works
Self-citationGenetic aspects of the antiphospholipid syndrome: An update
Sebastiani, G. D., Iuliano, A., Cantarini, L., & Galeazzi, M. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.01.005 · Cited by 46 · see citing works
Sialylated immunoglobulin G: a promising diagnostic and therapeutic strategy for autoimmune diseases
Li, D., Lou, Y., Zhang, Y., Liu, S., Li, J., & Tao, J. (2021) · Theranostics · doi:10.7150/thno.53961 · Cited by 44 · see citing works
Missing in action—The meaning of cell death in tissue damage and inflammation
Munoz, L. E., Leppkes, M., Fuchs, T. A., Hoffmann, M. H., & i, M. H. (2017) · Immunological Reviews · doi:10.1111/imr.12569 · Cited by 36 · see citing works
Magorivska, I., Munoz, L. E., Janko, C., Dumych, T. I., Rech, J., Schett, G. A., Nimmerjahn, F., Bilyy, R. O., & i, M. H. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12744 · Cited by 35 · see citing works
Self-citationβ2-Glycoprotein I-Reactive T Cells in Autoimmune Disease
Rauch, J., Salem, D., Subang, R., Kuwana, M., & Levine, J. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02836 · Cited by 33 · see citing works
Antiphospholipid syndrome's genetic and epigenetic aspects
Iuliano, A., Galeazzi, M., & Sebastiani, G. D. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102352 · Cited by 31 · see citing works
β2GP1, Anti-β2GP1 Antibodies and Platelets: Key Players in the Antiphospholipid Syndrome
Ho, Y. C., Ahuja, K., Körner, H., & Adams, M. J. (2016) · Antibodies · doi:10.3390/antib5020012 · Cited by 31 · see citing works
Stümer, J., Biermann, M. H. C., Knopf, J., Magorivska, I., Kastbom, A., Svärd, A., Janko, C., Bilyy, R. O., Schett, G. A., Sjöwall, C., et al. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.12987 · Cited by 30 · see citing works
Self-citationFlevaris, K., & Kontoravdi, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095180 · Cited by 29 · see citing works
Paryzhak, S. Y., Dumych, T. I., Mahorivska, I., Boichuk, M. O., Bila, G., Peshkova, S., Nehrych, T. I., & Bilyy, R. O. (2018) · Autoimmunity · doi:10.1080/08916934.2018.1514390 · Cited by 29 · see citing works
Self-citationHan, J., Zhou, Z.-C., Zhang, R., You, Y.-J., Guo, Z., Huang, J.-Y., Wang, F., Sun, Y., Liu, H.-L., Cheng, X.-B., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103883 · Cited by 27 · see citing works
Conrad, K., Andrade, L. E. C., Chan, E. K. L., Mähler, M., Meroni, P. L., Pruijn, G. J. M., Steiner, G. E., & Shoenfeld, Y. (2016) · Lupus · doi:10.1177/0961203316644337 · Cited by 24 · see citing works
Nalli, C., Somma, V., Andréoli, L., Büttner, T., Schierack, P., Mähler, M., Roggenbuck, D., & Tincani, A. (2018) · Autoimmunity Highlights · doi:10.1007/s13317-018-0106-0 · Cited by 23 · see citing works
Self-citationBertin, D., Camoin‐Jau, L., Veit, V., Resseguier, N., Lambert, M., Buffet Delmas, P., Heim, X., Mège, J., Morange, P., & Bardin, N. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15518 · Cited by 21 · see citing works
Anti-phospholipid Antibodies and Smoking: An Overview
Binder, S. R., & Litwin, C. M. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8565-4 · Cited by 21 · see citing works
Liu, T., Han, J., Zhang, R., Tang, Z., Yi, G., Gong, W., Wan, L., Hu, Q., Teng, J., Liu, H., et al. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab416 · Cited by 18 · see citing works
Glycosylation of random IgG distinguishes seropositive and seronegative rheumatoid arthritis
Magorivska, I., Döncző, B., Dumych, T. I., Karmash, A., Boichuk, M. O., Hychka, К. М., Mihalj, M., Szabó, M., Csánky, E., Rech, J., et al. (2018) · Autoimmunity · doi:10.1080/08916934.2018.1468886 · Cited by 15 · see citing works
Self-citationCiregia, F., Baiwir, D., Cobraiville, G., Dewael, T., Mazzucchelli, G., Badot, V., Romana, S. D., Sidiras, P., Sokolova, T., Durez, P., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-019-02188-9 · Cited by 14 · see citing works
Lambert, M., Brodovitch, A., Mège, J., Bertin, D., & Bardin, N. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103585 · Cited by 10 · see citing works
Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases
Knopf, J., Biermann, M. H. C., Munoz, L. E., & i, M. H. (2016) · Global Medical Genetics · doi:10.3934/genet.2016.4.280 · Cited by 10 · see citing works
Self-citationZhou, J., Hou, X., Zhang, H., Wang, T., & Cui, L. (2018) · Medical Science Monitor · doi:10.12659/msm.910369 · Cited by 8 · see citing works
Anti-inflammatory Activity of IgG-Fc
Beneduce, C., Kurtagic, E., & Bosques, C. J. (2019) · Current topics in microbiology and immunology · doi:10.1007/82_2019_148 · Cited by 5 · see citing works
Ho, Y. C., Ahuja, K., & Adams, M. J. (2017) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029617736384 · Cited by 5 · see citing works
Mechanisms of Action of the Antiphospholipid Antibodies
Chighizola, C. B., Raschi, E., Borghi, M. O., & Meroni, P. L. (2016) · Technical report · doi:10.1016/b978-0-444-63655-3.00003-x · Cited by 4 · see citing works
Immunoglobulin G Glycosylation in Diseases
Pezer, M. (2021) · Experientia supplementum · doi:10.1007/978-3-030-76912-3_13 · Cited by 4 · see citing works
Liou, L.-B., Wang, T.-Y., Liu, I.-J., Wu, H., Ke, P., Fang, Y., & Chen, Y. (2022) · Lupus · doi:10.1177/09612033221099766 · Cited by 2 · see citing works
Liou, L.-B., Tsai, P., Fang, Y., Chen, Y., Chen, C.-C., & Lai, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612998 · Cited by 2 · see citing works
Genetic and Epigenetic Aspects of Antiphospholipid Syndrome
Iuliano, A., Sebastiani, G. D., & Galeazzi, M. (2016) · Technical report · doi:10.1016/b978-0-444-63655-3.00005-3 · Cited by 1 · see citing works
Pathways of neutrophil activation by natural hydrophobic nanocrystals
Paryzhak, S. Y., Dumych, T. I., & Bilyy, R. O. (2018) · Experimental and Clinical Physiology and Biochemistry · doi:10.25040/ecpb2018.01.068 · Cited by 1 · see citing works
Self-citationHychka, К. М., Boichuk, M. O., Dumych, T. I., Paryzhak, S. Y., Билый, Р. О., & Nehrych, T. I. (2018) · Zaporozhye Medical Journal · doi:10.14739/2310-1210.2018.6.146558
- Authors
- Fickentscher, C., Magorivska, I., Janko, C., Biermann, M., Bilyy, R., Nalli, C., Tincani, A., Medeghini, V., Meini, A., Nimmerjahn, F., Schett, G., Muñoz, L. E., Andreoli, L., & Herrmann, M.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- National Academy of Sciences of Ukraine (UA)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy
- Department for Internal Medicine 3, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangen, Germany
- Venue
- Journal of Immunology Research
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-12
- ISSN
- 2314-7156 (ISSN-L)
- 2314-8861
- PMC
- PMC4491572
- OpenAlex
- W1603173612
- Cited by
- 37
- References
- 55
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 1
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Immunology Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- Friedrich-Alexander-Universität Erlangen-Nürnberg
- K. und R. Wucherpfennig-Stiftung
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- antiphospholipid syndrome, Fc glycosylation, sialylation, IgG subclasses, immune complexes, C3c, C1q, thrombosis, autoantibody pathogenicity, children
- MeSH terms
- Adolescent, Autoantibodies, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Glycosylation, Humans, Immunoglobulin G, Immunoglobulin M, Immunoglobulin Fc Fragments, Infant, Infant, Newborn, Male, Complement C1q, Complement C3c, Case-Control Studies, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, beta 2-Glycoprotein I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
