CoChat
Sign Up
Cited by 72Gastrointestinal motility and disordersGinger and Zingiberaceae researchComplementary and Alternative Medicine Studies

The Effect of Ginger ( Zingiber officinalis ) and Artichoke ( Cynara cardunculus ) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial

Open access
Giacosa, Attilio, Guido, Davide, Grassi, Mario, Riva, Antonella, Morazzoni, Paolo, Bombardelli, Ezio, Perna, Simone, Faliva, Milena A. +1 more·2015·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2015/915087PMC PMC4411465
Open this paper in CoChat — free accountOpen PDF

Abstract

Objective. Functional dyspepsia (FD) is a frequent clinical finding in western world. The aim of this study is to compare the efficacy of a ginger and artichoke supplementation versus placebo in the treatment of FD. Methods. A prospective multicentre, double blind, randomized, placebo controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was performed. Two capsules/day were supplied (before lunch and dinner) to 126 FD patients (supplementation/placebo: 65/61). Results . After 14 days of treatment, only supplementation group (SG) showed a significant amelioration (SG: α S = + 1.195 MCA score units (u), P = 0.017 ; placebo: α P = + 0.347 u, P = 0.513 ). The intercept ( α ) resulted to be significantly higher in SG than in placebo ( α S - α P = + 0.848 u, P < 0.001 ). At the end of the study, the advantage of SG versus placebo persists without variation ( β S - β P = + 0.077 u, P = 0.542 ). In SG, a significant advantage is observed for nausea ( β S - β P = - 0.398 u, P < 0.001 ), epigastric fullness ( β S - β P = - 0.241 , P < 0.001 ), epigastric pain ( β S - β P = - 0.173 u, P = 0.002 ), and bloating ( β S - β P = - 0.167 u, P = 0.017 ). Conclusions . The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2015/915087

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 35

  1. [1]Camilleri M. Dubois D. Coulie B. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US upper gastrointestinal study Clinical Gastroenterology and Hepatology 2005 3 6 543 552 10.1016/s1542-3565(05)00153-9 2-s2.0-20444502438 15952096 · DOI
  2. [2]Knill R. P. Jones R. P. Geografical differences in the prevalence of dyspepsia Scandinavian Journal of Gastroenterology 1991 26 17 24 1896825
  3. [3]Talley N. J. Zinsmeister A. R. Schleck C. D. Melton L. J. III Dyspepsia and dyspepsia subgroups: a population-based study Gastroenterology 1992 102 4 1259 1268 2-s2.0-0026547741 1551533
  4. [4]Holtmann G. E. H. Goebell H. Talley N. J. Dyspepsia in consulters and non-consulters: prevalence, health-care seeking behaviour and risk factors European Journal of Gastroenterology and Hepatology 1994 6 10 917 924 10.1097/00042737-199410000-00014 2-s2.0-0028025322 · DOI
  5. [5]Talley N. J. Stanghellini V. Heading R. C. Koch K. L. Malagelada J. R. Tytgat G. N. Functional gastroduodenal disorders Gut 1999 45 2 1137 1142 PMC1766695 10457043
  6. [6]Ford A. C. Bercik P. Morgan D. G. Bolino C. Pintos-Sanchez M. I. Moayyedi P. The Rome III criteria for the diagnosis of functional dyspepsia in secondary care are not superior to previous definitions Gastroenterology 2014 146 4 932 940 10.1053/j.gastro.2014.01.014 2-s2.0-84896444195 24417817 · DOI
  7. [7]Mahadeva S. Goh K. L. Epidemiology of dyspepsia: a global perspective World Journal of Gastroenterology 2006 12 17 2661 2666 16718749 PMC4130971
  8. [8]Haag S. Talley N. J. Holtmann G. Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consulters Gut 2004 53 10 1445 1451 10.1136/gut.2003.030049 2-s2.0-4644359907 15361493 PMC1774225 · DOI
  9. [9]Stanghellini V. de Ponti F. de Giorgio R. Barbara G. Tosetti C. Corinaldesi R. New developments in the treatment of functional dyspepsia Drugs 2003 63 9 869 892 10.2165/00003495-200363090-00003 2-s2.0-0038222635 12678573 · DOI
  10. [10]Talley N. J. Dyspepsia: management guidelines for the millennium Gut 2002 50 4 iv72 iv78 2-s2.0-0036116758 11953354 PMC1867696
  11. [11]Micklefield G. H. Redeker Y. Meister V. Jung O. Greving I. May B. Effects of ginger on gastroduodenal motility International Journal of Clinical Pharmacology and Therapeutics 1999 37 7 341 346 2-s2.0-0032785389 10442508
  12. [12]Ernst E. Pittler M. H. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials British Journal of Anaesthesia 2000 84 3 367 371 10.1093/oxfordjournals.bja.a013442 2-s2.0-0034000843 10793599 · DOI
  13. [13]Holtmann G. Adam B. Haag S. Collet W. Grünewald E. Windeck T. Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial Alimentary Pharmacology & Therapeutics 2003 18 11-12 1099 1105 10.1046/j.1365-2036.2003.01767.x 2-s2.0-0346433968 14653829 · DOI
  14. [15]Talley N. J. Haque M. Wyeth J. W. Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index Alimentary Pharmacology & Therapeutics 1999 13 2 225 235 10.1046/j.1365-2036.1999.00445.x 2-s2.0-0032992354 10102954 · DOI
  15. [19]Mair P. de Leeuw J. A general framework for multivariate analysis with optimal scaling: the R package aspect Journal of Statistical Software 2010 32 9 1 23 2-s2.0-77949337641
  16. [21]Rosseel Y. Lavaan: an R package for structural equation modeling Journal of Statistical Software 2012 48 2 1 36 2-s2.0-84863306901
  17. [23]Dobrilla G. Comberlato M. Steele A. Vallaperta P. Drug treatment of functional dyspepsia. A meta-analysis of randomized controlled clinical trials Journal of Clinical Gastroenterology 1989 11 2 169 177 10.1097/00004836-198904000-00011 2-s2.0-0024520544 2567747 · DOI
  18. [24]Futagami S. Shimpuku M. Yin Y. Pathophysiology of functional dyspepsia Journal of Nippon Medical School 2011 78 5 280 285 10.1272/jnms.78.280 2-s2.0-80054757237 22041874 · DOI
  19. [26]Wu K.-L. Rayner C. K. Chuah S.-K. Effects of ginger on gastric emptying and motility in healthy humans European Journal of Gastroenterology & Hepatology 2008 20 5 436 440 10.1097/meg.0b013e3282f4b224 2-s2.0-42149108064 18403946 · DOI · Paper page
  20. [27]Ali B. H. Blunden G. Tanira M. O. Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research Food and Chemical Toxicology 2008 46 2 409 420 10.1016/j.fct.2007.09.085 2-s2.0-37349127807 17950516 · DOI
  21. [28]Gebhardt R. Fausel M. Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes Toxicology in Vitro 1997 11 5 669 672 10.1016/s0887-2333(97)00078-7 2-s2.0-0030730138 20654368 · DOI
  22. [30]Brown J. E. Rice-Evans C. A. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro Free Radical Research 1998 29 3 247 255 10.1080/10715769800300281 2-s2.0-0031794962 9802556 · DOI
  23. [31]Pérez-García F. Adzet T. Cañigueral S. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes Free Radical Research 2000 33 5 661 665 10.1080/10715760000301171 2-s2.0-0034493209 11200096 · DOI
  24. [32]Rechner A. R. Pannala A. S. Rice-Evans C. A. Caffeic acid derivatives in artichoke extract are metabolised to phenolic acids in vivo Free Radical Research 2001 35 2 195 202 10.1080/10715760100300741 2-s2.0-0034908141 11697200 · DOI
  25. [33]Ishida K. Kojima R. Tsuboi M. Tsuda Y. Ito M. Effects of artichoke leaf extract on acute gastric mucosal injury in rats Biological and Pharmaceutical Bulletin 2010 33 2 223 229 10.1248/bpb.33.223 2-s2.0-76049108574 20118544 · DOI
  26. [34]Emendörfer F. Bellato F. Noldin V. F. Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum Biological and Pharmaceutical Bulletin 2005 28 5 902 904 10.1248/bpb.28.902 2-s2.0-19644384001 15863902 · DOI
  27. [35]Ding M. Leach M. Bradley H. The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review Women and Birth 2013 26 1 e26 e30 10.1016/j.wombi.2012.08.001 2-s2.0-84875403314 22951628 · DOI
  28. [36]Ryan J. L. Heckler C. E. Roscoe J. A. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients Supportive Care in Cancer 2012 20 7 1479 1489 10.1007/s00520-011-1236-3 2-s2.0-84863983534 21818642 PMC3361530 · DOI
  29. [37]Thomson M. Corbin R. Leung L. Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis Journal of the American Board of Family Medicine 2014 27 1 115 122 10.3122/jabfm.2014.01.130167 2-s2.0-84892594728 24390893 · DOI
  30. [38]Kirchhoff R. Beckers C. Kirchhoff G. Trinczek-Gärtner H. Petrowicz O. Reimann H. Increase in choleresis by means of artichoke extract. Results of a randomized placebo-controlled double blind study Phytomedicine 1994 1 2 107 115 10.1016/s0944-7113(11)80027-9 23195882 · DOI
  31. [39]Aggarwal A. Bhatt M. Commonly used gastrointestinal drugs Handbook of Clinical Neurology 2014 120 633 643 10.1016/b978-0-7020-4087-0.00043-7 2-s2.0-84890849639 24365343 · DOI
  32. [40]van Roeden S. E. Belle-van Meerkerk G. van Tuyl S. A. C. van De Ree M. A. Muller A. F. Domperidone and the risk of sudden cardiac death Nederlands Tijdschrift voor Geneeskunde 2013 157 46 A6770 2-s2.0-84891339777 24191928
  33. [41]Hondeghem L. M. Domperidone: limited benefits with significant risk for sudden cardiac death Journal of Cardiovascular Pharmacology 2013 61 3 218 225 10.1097/fjc.0b013e31827afd0d 2-s2.0-84875232401 23188128 · DOI
  34. [42]Michaud V. Turgeon J. Domperidone and sudden cardiac death: how much longer should we wait? Journal of Cardiovascular Pharmacology 2013 61 3 215 217 10.1097/fjc.0b013e31827e2573 2-s2.0-84875223232 23328387 · DOI
  35. [43]Kanji S. Stevenson A. Hutton B. Sudden cardiac death and ventricular arrhythmias associated with domperidone: evidence supporting health Canada’s warning The Canadian Journal of Hospital Pharmacy 2014 67 4 311 312 10.4212/cjhp.v67i4.1378 25214665 PMC4152973 · DOI

Cited by

Sorted by citations

Authors
Giacosa, A., Guido, D., Grassi, M., Riva, A., Morazzoni, P., Bombardelli, E., Perna, S., Faliva, M. A., & Rondanelli, M.
Affiliations
  • Department of Gastroenterology, Policlinico di Monza, 20900 Milan, Italy
  • University of Pavia (IT)
  • Indena (Italy) (IT)
Corresponding author
Rondanelli, Mariangela
ORCID
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-9
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
DOI
10.1155/2015/915087
PMC
PMC4411465
OpenAlex
W2092666048
Cited by
72
References
1
Citations by year
2026: 8 · 2025: 13 · 2024: 7 · 2023: 10 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 6
FWCI
5.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Keywords
functional dyspepsia, ginger extract, artichoke leaf extract, dietary supplementation, nausea, epigastric pain, bloating, epigastric fullness, complementary therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review