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A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls
Open accessAbstract
This study compared flow-mediated dilatation (FMD), peripheral artery tonometry (PAT), and serum nitric oxide (NO) measures of endothelial function in patients with peripheral artery disease (PAD) against age/gender matched controls. 25 patients (mean age: 72.4 years, M : F 18 : 7) with established PAD and an age/gender matched group of 25 healthy controls (mean age: 72.4 years, M : F 18 : 7) were studied. Endothelial function was measured using the % FMD, reactive hyperemia index (RHI) using PAT and serum NO (μ mol). Difference for each method between PAD and control patients and correlation between the methods were investigated. FMD and RHI were lower in patients with PAD (median FMD for PAD = 2.16% versus control = 3.77%,p=0.034and median RHI in PAD = 1.64 versus control = 1.92,p=0.005). NO levels were not significantly different between the groups (PAD median = 7.70 μ mol, control median = 13.05 μ mol,p=0.662). These results were obtained in elderly patients and cannot be extrapolated to younger individuals. FMD and PAT both demonstrated a lower hyperaemic response in patients with PAD; however, FMD results in PAD patients were unequivocally reduced whereas half the PAD patients had RHI values above the established threshold for endothelial dysfunction. This suggests that FMD is a more appropriate method for the measurement of NO-mediated endothelial function.
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“To assess endothelial function, PAT, a non-invasive technique similar to FMD, was used to measure the hyperemic response. This had certain limitations considering that the data generated by endoPAT have more variability in their results compared to the FMD technique [43].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [43]
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References 28 · Cited by 20
Metadata
- Authors
- Allan, R. B., Vun, S. V., & Spark, J. I.
- Affiliations
- Flinders University (AU)
- Corresponding author
- Spark, J. Ian
- Venue
- International Journal of Vascular Medicine
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-6
- ISSN
- 2090-2824 (ISSN-L)
- 2090-2832
- PMC
- PMC4752993
- OpenAlex
- W2290762340
- Cited by
- 20
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Vascular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Funders
- Heart Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- peripheral arterial disease, endothelial function, flow-mediated dilation, reactive hyperemia index, serum nitric oxide, endothelial dysfunction, elderly patients
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- Allan, R. B., Vun, S. V., & Spark, J. I. (2016). A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls. International Journal of Vascular Medicine. https://doi.org/10.1155/2016/2969740
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