Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy
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This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. Serum XOD activity, ischemia-modified albumin (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation end products (AGE), total free thiols, atherogenic index of plasma (AIP), and body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without DPN), and 30 nondiabetic control subjects. Duration of diabetes, hypertension, medication, and microalbuminuria was recorded. Serum XOD activities in controls, non-DPN, and DPN were5.7±2.4 U/L,20.3±8.6 U/L, and27.5±10.6 U/L (p<0.01), respectively. XOD activity was directly correlated to IMA, UA, BMI, HbA1c, and AGE, while inversely correlated to serum total free thiols. A multivariable logistic regression model, which included duration of diabetes, hypertension, AIP, HbA1c, UA, and XOD activity, revealed HbA1c [OR = 1.03 (1.00–1.05);p=0.034] and XOD activity [OR = 1.07 (1.00–1.14);p=0.036] as independent predictors of DPN. Serum XOD activity was well correlated to several other risk factors. These results indicate the role of XOD in the development of DPN among T2DM patients.
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The NOX enzymes together with mitochondrial superoxide represent the most important sources of ROS in diabetes mellitus and diabetic micro-/macro-vascular diseases.
“The NOX enzymes together with mitochondrial superoxide represent the most important sources of ROS in diabetes mellitus and diabetic micro-/macro-vascular diseases (Forbes et al. 2008; Miric et al. 2016).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Miric et al. 2016
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- Authors
- Miric, D. J., Kisic, B. M., Filipovic-Danic, S., Grbic, R., Dragojevic, I., Miric, M. B., & Puhalo-Sladoje, D.
- Affiliations
- University of Priština - Kosovska Mitrovica (XK)
- Institute of Biochemistry, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia
- Clinics for Neurology and Psychiatry, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia
- Clinics for General and Orthopedics Surgery, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia
- University of East Sarajevo (BA)
- Corresponding author
- Miric, Dijana J.
- Venue
- Journal of Diabetes Research
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-7
- ISSN
- 2314-6745 (ISSN-L)
- 2314-6753
- PMC
- PMC5124663
- OpenAlex
- W2552668956
- Cited by
- 70
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 10 · 2022: 3 · 2021: 12 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 5
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Diabetes Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Keywords
- xanthine oxidase, type 2 diabetes, diabetic peripheral neuropathy, serum enzyme activity, ischemia-modified albumin, uric acid, HbA1c, advanced glycation end products, atherogenic index of plasma, body mass index, risk factors, oxidative stress
- MeSH terms
- Serum Albumin, Human, Aged, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Female, Glycated Hemoglobin, Humans, Hypertension, Male, Middle Aged, Serum Albumin, Sulfhydryl Compounds, Time Factors, Uric Acid, Xanthine Oxidase, Biomarkers, Body Mass Index, Multivariate Analysis, Logistic Models, Case-Control Studies, Glycation End Products, Advanced
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