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The Role of Obesity in Sepsis Outcome among Critically Ill Patients: A Retrospective Cohort Analysis
Abstract
Background.The objective of this study was to assess the correlation between sepsis, obesity, and mortality of patients admitted to an Intensive Care Unit (ICU).Subjects and Methods.Data of all patients admitted to the ICU of a tertiary hospital during a 28-month period were retrospectively analyzed and included in the study.Results.Of 834 patients included, 163 (19.5%) were obese, while 25 (3.0%) were morbidly obese. Number of comorbidities (P<0.001), bloodstream infection (P 0.033), and carbapenemase-producing Klebsiella pneumoniae colonization during ICU stay (P 0.005) were significantly associated with obesity, while nonobese patients suffered more frequently from spontaneous intracranial hemorrhage (P 0.038). Total ICU mortality was 22.5%. Increased mortality among obese ICU patients was observed. Sepsis was the main condition of admission for which obese patients had statistically lower survival than normal weight subjects (76.3% versus 43.7%;P 0.001). Mortality of septic patients upon admission was independently associated with SOFA score upon ICU admission (P 0.003), obesity (P 0.014), pneumonia (P 0.038), and development of septic shock (P 0.015).Conclusions.Our study revealed that sepsis upon ICU admission is adversely influenced by obesity but further studies are needed in order to assess the role of obesity in sepsis outcome.
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“The next most common comorbidities are highly networked conditions strongly associated with social stress and economic marginalization including diabetes mellitus, hypertension, cardiovascular disease (CVD) and stroke, obesity, chronic kidney disease and chronic obstructive pulmonary disease (COPD)”
From On race, human variation, and who gets and dies of sepsis (2022) · cites this paper as Papadimitriou‐Olivgeris et al., 2016
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Metadata
- Authors
- Papadimitriou-Olivgeris, M., Aretha, D., Zotou, A., Koutsileou, K., Zbouki, A., Lefkaditi, A., Sklavou, C., Marangos, M., & Fligou, F.
- Affiliations
- Division of Infectious Diseases, School of Medicine, University of Patras, Rion, 26504 Patras, Greece
- Department of Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Rion, 26504 Patras, Greece
- ORCID
- Aretha, Diamanto
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-9
- ISSN
- 2314-6133
- 2314-6141
- PMC
- PMC5061945
- Cited by
- 42
- References
- 0
- Language
- en
- Funders
- Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Greece
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