The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Platelet-Rich Plasma: The Choice of Activation Method Affects the Release of Bioactive Molecules
Open accessAbstract
Platelet-Rich Plasma (PRP) is a low-cost procedure to deliver high concentrations of autologous growth factors (GFs). Platelet activation is a crucial step that might influence the availability of bioactive molecules and therefore tissue healing. Activation of PRP from ten voluntary healthy males was performed by adding 10% of CaCl 2, 10% of autologous thrombin, 10% of a mixture of CaCl 2+ thrombin, and 10% of collagen type I. Blood derivatives were incubated for 15 and 30 minutes and 1, 2, and 24 hours and samples were evaluated for the release of VEGF, TGF-β 1, PDGF-AB, IL-1 β, and TNF-α. PRP activated with CaCl 2, thrombin, and CaCl 2/thrombin formed clots detected from the 15-minute evaluation, whereas in collagen-type-I-activated samples no clot formation was noticed. Collagen type I produced an overall lower GF release. Thrombin, CaCl 2/thrombin, and collagen type I activated PRPs showed an immediate release of PDGF and TGF-β1that remained stable over time, whereas VEGF showed an increasing trend from 15 minutes up to 24 hours. CaCl 2 induced a progressive release of GFs from 15 minutes and increasing up to 24 hours. The method chosen to activate PRP influences both its physical form and the releasate in terms of GF amount and release kinetic.
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Cites
Platelet-Rich Plasma: From Basic Science to Clinical Applications
Foster, T. E., Puskas, B. L., Mandelbaum, B. R., Gerhardt, M. B., & Rodeo, S. A. (2009) · The American Journal of Sports Medicine · doi:10.1177/0363546509349921 · Cited by 1,323
Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration
Weibrich, G., Hansen, T., Kleis, W., Buch, R., & Hitzler, W. E. (2004) · Bone · doi:10.1016/j.bone.2003.12.010 · Cited by 628
Platelet-Rich Plasma: The PAW Classification System
DeLong, J. M., Russell, R. P., & Mazzocca, A. D. (2012) · Arthroscopy: The Journal of Arthroscopic & Related Surgery · doi:10.1016/j.arthro.2012.04.148 · Cited by 623
Zhu, Y., Yuan, M., Meng, H. Y., Wang, A. Y., Guo, Q. Y., Wang, Y., & Peng, J. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.07.017 · Cited by 366
Optimization of Leukocyte Concentration in Platelet-Rich Plasma for the Treatment of Tendinopathy
McCarrel, T. M., Minas, T., & Fortier, L. A. (2012) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.l.00019 · Cited by 358
Lopez-Vidriero, E., Goulding, K. A., Simon, D. A., Sanchez, M., & Johnson, D. H. (2010) · Arthroscopy: The Journal of Arthroscopic & Related Surgery · doi:10.1016/j.arthro.2009.11.015 · Cited by 314
Antimicrobial activity of platelet‐leukocyte gel against Staphylococcus aureus
Moojen, D. J. F., Everts, P. A. M., Schure, R., Overdevest, E. P., van Zundert, A., Knape, J. T. A., Castelein, R. M., Creemers, L. B., & Dhert, W. J. A. (2008) · Journal of Orthopaedic Research · doi:10.1002/jor.20519 · Cited by 298
Filardo, G., Kon, E., Roffi, A., Di Matteo, B., Merli, M. L., & Marcacci, M. (2015) · Knee Surgery, Sports Traumatology, Arthroscopy · doi:10.1007/s00167-013-2743-1 · Cited by 270
Self-citationPlatelet‐rich plasma (PRP) to treat sports injuries: evidence to support its use
Kon, E., Filardo, G., Di Martino, A., & Marcacci, M. (2011) · Knee Surgery, Sports Traumatology, Arthroscopy · doi:10.1007/s00167-010-1306-y · Cited by 253
Self-citationPlatelet Activation by Collagen Provides Sustained Release of Anabolic Cytokines
Harrison, S., Vavken, P., Kevy, S., Jacobson, M., Zurakowski, D., & Murray, M. M. (2011) · The American Journal of Sports Medicine · doi:10.1177/0363546511401576 · Cited by 221
Cited by
Chen, X., Jones, I. A., Park, C., & Vangsness, C. T. (2018) · The American Journal of Sports Medicine · doi:10.1177/0363546517743746 · Cited by 294
The potential of platelet-rich plasma injections and stem cell therapy for penile rejuvenation
Israeli, J. M., Lokeshwar, S. D., Efimenko, I. V., Masterson, T. A., & Ramasamy, R. (2022) · International Journal of Impotence Research · doi:10.1038/s41443-021-00482-z · Cited by 30
“AA-PRP is produced by introducing an exogenous activator such as calcium and is thought to contain higher concentrations of growth factors and cytokines [22].”
Background
Metadata
- Authors
- Cavallo, C., Roffi, A., Grigolo, B., Mariani, E., Pratelli, L., Merli, G., Kon, E., Marcacci, M., & Filardo, G.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-7
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2510968112
- Cited by
- 317
- References
- 26
- FWCI
- 23.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cavallo, C., Roffi, A., Grigolo, B., Mariani, E., Pratelli, L., Merli, G., Kon, E., Marcacci, M., & Filardo, G. (2016). Platelet-Rich Plasma: The Choice of Activation Method Affects the Release of Bioactive Molecules. BioMed Research International. https://doi.org/10.1155/2016/6591717
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