Characteristics of Human endometrium-derived mesenchymal stem cells and their tropism to endometriosis
Open accessAbstract
Human endometrial tissue has become an attractive source of mesenchymal stem cells (MSCs) for cell-based therapies because these MSCs can be easily harvested and have tumour tropism as well as reduced immunogenic and inflammatory properties. Our study aimed to obtain and characterise human endometrial mesenchymal stem cells (EMSCs) and assess their endometriosis tropism. EMSCs were successfully isolated from the endometrium of women undergoing laparoscopy for idiopathic infertility. The EMSCs presented a fibroblast-like morphology during culture. Flow cytometry analyses showed that the cells were positive for the specific stem cell markers CD73, CD90, CD105, CD166, and HLA-ABC (major histocompatibility complex class I (MHC I)) but negative for CD14, CD34, CD45, and HLA-DR (MHC II). Reverse transcription polymerase chain reaction results showed that the EMSCs expressed the stem cell marker OCT4. The EMSCs could differentiate into osteocytes, adipocytes, and chondrocytes under certain conditions. The EMSCs had a high tropism to endometriosis without tumourigenicity. This study enhances the possibility of using EMSCs as drug carriers in human cell-based therapies. Meanwhile, future research could also focus on developing targeted therapies for endometriosis.
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Mesothelial-to-mesenchymal transition in the peritoneal cavity is well known, with a specific role of platelets.
“Mesothelial-to-mesenchymal transition in the peritoneal cavity is well known (124, 125) with a specific role of platelets (48).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [125]
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Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766 · cited 1× · see citing works
“The cells also expressed high levels of CD73, CD90, CD105, and CD166, which are the main stem cell markers, but they lacked CD14, CD34, and CD45 expression; these results were in agreement with those of previous studies [6, 12, 30].”
ResultGiudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166 · see citing works
Eskenazi, B., & Warner, M. L. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70302-8 · Cited by 1,617 · see citing works
(1927) · PubMed Central · Cited by 1,008 · see citing works
Endometriosis and infertility: pathophysiology and management
de Ziegler, D., Borghese, B., & Chapron, C. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60490-4 · Cited by 836 · cited 1× · see citing works
“It is responsible for chronic pelvic pain, dyspareunia, dysmenorrhoea, and infertility in women of childbearing age [19, 20].”
BackgroundClonogenicity of Human Endometrial Epithelial and Stromal Cells1
Chan, R. W. S., Schwab, K. E., & Gargett, C. E. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.024109 · Cited by 653 · cited 2× · see citing works
“The medium was changed after 3 days to remove nonadherent cells [11].”
BackgroundMethodIsolation and Culture of Epithelial Progenitors and Mesenchymal Stem Cells from Human Endometrium1
Gargett, C. E., Schwab, K. E., Zillwood, R. M., Nguyen, H. P. T., & Wu, D. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.075226 · Cited by 476 · see citing works
Berkley, K. J., Rapkin, A. J., & Papka, R. E. (2005) · Science · doi:10.1126/science.1111445 · Cited by 455 · see citing works
Novel Sources of Fetal Stem Cells: Where do they Fit on the Developmental Continuum?
Pappa, K. I., & Anagnou, N. P. (2009) · Regenerative Medicine · doi:10.2217/rme.09.12 · Cited by 217 · see citing works
Sutton, M. T., Fletcher, D., Ghosh, S. K., Weinberg, A., Heeckeren, R. V., Kaur, S., Sadeghi, Z., Hijaz, A., Reese, J., Lazarus, H. M., et al. (2016) · Stem Cells International · doi:10.1155/2016/5303048 · Cited by 171 · cited 1× · see citing works
“MSCs are currently one of the most promising candidates for cell-based targeted therapies due to their low immunogenicity, nontumourigenicity, and tumour tropism [1, 8, 27].”
BackgroundOn the concept of stem cell and a model of functional-morphological structure of the endometrium
Prianishnikov, V. A. (1978) · Contraception · doi:10.1016/s0010-7824(78)80015-8 · Cited by 162 · cited 1× · see citing works
“Endometrial stem cells were first introduced by Prianishnikov in 1978 [10] and were separated from endometrial tissue by Chan et al.”
BackgroundDevelopment of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors
Rachakatla, R. S., Marini, F., Weiss, M. L., Tamura, M., & Troyer, D. L. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701077 · Cited by 125 · cited 1× · see citing works
“There have been studies on the antitumour effects of MSCs from the bone marrow and other sources [5, 8, 9], but few have focused on endometrial mesenchymal stem cells (EMSCs).”
BackgroundAmniotic Fluid and Amniotic Membrane Stem Cells: Marker Discovery
Roubelakis, M. G., Trohatou, O., & Anagnou, N. P. (2012) · Stem Cells International · doi:10.1155/2012/107836 · Cited by 120 · cited 1× · see citing works
“Much of the available literature demonstrates that MSCs have a tropism to tumour tissues and sites of inflammation [8, 33].”
BackgroundDarzi, S., Werkmeister, J. A., Deane, J. A., & Gargett, C. E. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0190 · Cited by 112 · cited 1× · see citing works
“The cells were capable of differentiating into adipocytes, osteocytes, and chondrocytes in vitro, which indicated their multipotency [12, 31].”
BackgroundStandardization and Safety of Alveolar Bone–derived Stem Cell Isolation
Mason, S. N., Tarlé, S. A., Osibin, W., Kinfu, Y., & Kaigler, D. (2013) · Journal of Dental Research · doi:10.1177/0022034513510530 · Cited by 89 · cited 1× · see citing works
“MSCs exhibit such characteristics as high proliferation, selfrenewal, multipotency, low immunogenicity, and nononcogenicity [6, 7].”
BackgroundLi, H., Yu, B., Li, J., Su, L., Yan, M., Zhang, J., Li, C., Zhu, Z., & Liu, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125013 · Cited by 84 · see citing works
Genetic Basis of Endometriosis
Bischoff, F. Z., & Simpson, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.030 · Cited by 82 · see citing works
Endometrial stem cells in regenerative medicine
Verdi, J., Tan, A., Shoae‐Hassani, A., & Seifalian, A. M. (2014) · Journal of Biological Engineering · doi:10.1186/1754-1611-8-20 · Cited by 79 · cited 1× · see citing works
“The utilisation of EMSCs has been studied in regenerative medicine [13, 28].”
Background(2008) · PubMed · Cited by 74 · see citing works
Wolff, E. F., Mutlu, L., Massasa, E. E., Elsworth, J. D., Redmond, D. E., & Taylor, H. S. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12433 · Cited by 66 · see citing works
Su, K. C., Edwards, S. L., Tan, K. S., White, J., Kandel, S., Ramshaw, J. A. M., Gargett, C. E., & Werkmeister, J. A. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.08.031 · Cited by 64 · see citing works
Bitsika, V., Roubelakis, M. G., Zagoura, D., Trohatou, O., Makridakis, M., Pappa, K. I., Marini, F. C., Vlahou, A., & Anagnou, N. P. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0151 · Cited by 57 · cited 1× · see citing works
“There have been studies on the antitumour effects of MSCs from the bone marrow and other sources [5, 8, 9], but few have focused on endometrial mesenchymal stem cells (EMSCs).”
BackgroundNigjeh, M. N., Amoabedini, G., Noroozi, A., Azami, M., Asmani, M. N., Ebrahimi‐Barough, S., Saberi, H., Ai, A., & Ai, J. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34921 · Cited by 57 · see citing works
Endometrial Mesenchymal Stem Cells Isolated from Menstrual Blood by Adherence
Du, X., Yuan, Q., Qu, Y., Zhou, Y., & Jia, B. (2015) · Stem Cells International · doi:10.1155/2016/3573846 · Cited by 49 · cited 1× · see citing works
“Louis, MO, USA) to assess osteogenesis, adipogenesis, and chondrogenesis, respectively [25].”
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse
Emmerson, S., & Gargett, C. E. (2016) · World Journal of Stem Cells · doi:10.4252/wjsc.v8.i5.202 · Cited by 48 · cited 1× · see citing works
“The utilisation of EMSCs has been studied in regenerative medicine [13, 28].”
BackgroundMesenchymal Stem Cells as Therapeutic Delivery Vehicles Targeting Tumor Stroma
Serakıncı, N., Christensen, R., Fahrioğlu, U., Sørensen, F. B., Dagnæs‐Hansen, F., Hájek, M., Jensen, T. H., Kølvraa, S., & Keith, W. N. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2011.1024 · Cited by 41 · cited 5× · see citing works
“MSC-based targeted drug delivery systems have a distinct advantage, that is, they have the unique characteristics of eosinophilic tumour sites, and compared with the platforms of other targeted drug delivery systems, MSCs can migrate to tumour sites [8] regardless of tumour size, location, or source.”
BackgroundInfluentialHigh OCT4 and Low p16 INK4A Expressions Determine In Vitro Lifespan of Mesenchymal Stem Cells
Piccinato, C. D. A., Sertie, A. L., Torres, N., Ferretti, M., & Antonioli, E. (2015) · Stem Cells International · doi:10.1155/2015/369828 · Cited by 40 · cited 2× · see citing works
“The PCR products were visualised on a 1% agarose gel with ethidium bromide [24].”
BackgroundMethodNajar, M., Raicevic, G., André, T., Fayyad‐Kazan, H., Pieters, K., Bron, D., Toungouz, M., & Lagneaux, L. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2015.11.013 · Cited by 36 · cited 1× · see citing works
“In our study, the cells we separated and cultured exhibited a long spindle shape and a swirling arrangement, similar to the features of other MSC types, as described elsewhere [6, 29].”
ResultSurgical History and the Risk of Endometriosis:A Hospital-Based Case-Control Study
Liu, X., Long, Q., & Guo, S. (2016) · Reproductive Sciences · doi:10.1177/1933719116632921 · Cited by 35 · cited 2× · see citing works
“Traditional surgical approaches can excise ectopic lesions, but the disease recurs in many patients [22, 23].”
BackgroundLi, L., Wang, D., Zhou, J., Cheng, Y., Liang, T., & Zhang, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123350 · Cited by 26 · cited 4× · see citing works
“The cells also expressed high levels of CD73, CD90, CD105, and CD166, which are the main stem cell markers, but they lacked CD14, CD34, and CD45 expression; these results were in agreement with those of previous studies [6, 12, 30].”
BackgroundMethodResultInfluentialLi, J., Peng, X., Zeng, X., Liu, B., Hao, Q., Yu, X., Zhu, L., & Hu, Q. (2015) · Scientific Reports · doi:10.1038/srep15286 · Cited by 22 · cited 1× · see citing works
“MSCs are currently one of the most promising candidates for cell-based targeted therapies due to their low immunogenicity, nontumourigenicity, and tumour tropism [1, 8, 27].”
BackgroundCheng, K., Rai, P., Lan, X., Plagov, A., Malhotra, A., Gupta, S. K., & Singhal, P. C. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.06.008 · Cited by 17 · see citing works
Lu, X.-E., Ning, W., Dong, M.-Y., Liu, A., Jin, F., & Huang, H. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.12.083 · Cited by 16 · cited 1× · see citing works
“In previous studies, the increased expression of VEGF facilitates the survival of ectopic tissue in the peritoneal cavity and the development of endometriotic lesions [36].”
BackgroundBiology and clinical applications of marrow mesenchymal stem cells
Carlo‐Stella, C., & Gianni, M. A. (2004) · Pathologie Biologie · doi:10.1016/j.patbio.2004.03.009 · Cited by 10 · see citing works
Piccirillo, N., Ausoni, G., Chiusolo, P., Sorà, F., Putzulu, R., Bianchi, M., Maresca, M., Fiore, A., Oppedisano, P., Sica, S., et al. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2012.12.003 · Cited by 7 · cited 1× · see citing works
“According to the definition provided by the Committee of the International Society for Cellular Therapy, MSCs are multipotent cells that are adhere to plastic; that express CD73, CD90, and CD105 instead of CD14, CD34, CD45, and HLA-DR; and that must be able to differentiate into osteoblasts, adipocytes, and chondrobla…”
Method[Medical treatment of endometriosis].
Derouich, S., Attia, L., Slimani, O., Bouzid, A., Mathlouthi, N., Temime, R. B., & Makhlouf, T. (2015) · PubMed · Cited by 7 · see citing works
[Establishment of endometriosis subcutaneous model in immunodeficient nude mice].
Ni, H. J., Zhang, Z., Dai, Y., & Zhang, S. Y. (2016) · PubMed · doi:10.3760/cma.j.issn.0376-2491.2016.33.016 · Cited by 3 · cited 1× · see citing works
“2ml of NS as the negative control [26].”
Method
Flagged first, then by citations
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Sorted by citations
Pathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241 · see citing works
Lin, Y.-H., Chen, Y.-H., Chang, H.-Y., Au, H., Tzeng, C., & Huang, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082385 · Cited by 187 · see citing works
“Although few studies have investigated endometrial MSCs, results suggest that they are a safe cell type that does not promote endometriosis progression [262,263].”
BackgroundNew Insights in Pathogenesis of Endometriosis
Signorile, P. G., Viceconte, R., & Baldi, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.879015 · Cited by 88 · see citing works
“In contrast to endometrial epithelial stem cells, mesenchymal stem cells not only are normally present in the endometrium (31), but they can be readily isolated and enriched (32).”
BackgroundCheng, S., Nethi, S. K., Rathi, S., Layek, B., & Prabha, S. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.259796 · Cited by 85 · see citing works
Single‐cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium
Kirkwood, P. M., Gibson, D. A., Smith, J. R., Wilson‐Kanamori, J. R., Kelepouri, O., Esnal‐Zufiaurre, A., Dobie, R., Henderson, N. C., & Saunders, P. T. K. (2021) · The FASEB Journal · doi:10.1096/fj.202002123r · Cited by 79 · see citing works
Endometriosis: A Comprehensive Review
Arafah, M., Rashid, S., & Akhtar, M. (2020) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000288 · Cited by 82 · see citing works
Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine
Lv, H., Hu, Y., Cui, Z., & Jia, H. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1067-y · Cited by 78 · see citing works
The known, the unknown and the future of the pathophysiology of endometriosis
Ochoa Bernal, M. A., & Fazleabas, A. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115815 · Cited by 59 · see citing works
“These types of cells are usually present in the endometrial tissue [37].”
BackgroundAsencio, F. D. A., Ribeiro, H. S. A. A., Ribeiro, P. A., Malzoni, M., Adamyan, L. V., Ussia, A., Gomel, V., Martin, D. C., & Koninckx, P. R. (2019) · Gynecological Surgery · doi:10.1186/s10397-019-1056-x · Cited by 53 · see citing works
Manaph, N. P. A., Sivanathan, K., Nitschke, J., Zhou, X.-F., Coates, P., & Drogemuller, C. (2019) · Stem cell research & therapeutics · doi:10.1186/s13287-019-1396-5 · Cited by 46 · see citing works
“Endometrium CD73, CD90, CD105, CD166, HLA-ABC, Oct-4, CD14, CD34, CD45, HLA-DR No [48]”
Cabezas, J. G., Rojas, D. M., Navarrete, F., Ortiz, R., Rivera, G., Saravia, F., Rodriguez-Alvarez, L., & Castro, F. O. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.09.035 · Cited by 43 · see citing works
Liu, Y., Zhang, Z., Yang, F., Wang, H., Liang, S., Wang, H., Yang, J., & Lin, J. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa011 · Cited by 43 · see citing works
“Furthermore, patients with endometriosis have more tissue shedding from the basal layer during menstruation than do healthy individuals, and EnSCEM-Eu also show more chemotaxis to ectopic lesions, which can enrich EnSCs for the formation of ectopic lesions [20, 55].”
BackgroundLiu, Y., Liang, S., Yang, F., Sun, Y., Niu, L., Ren, Y., Wang, H., He, Y., Du, J., Yang, J., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01856-8 · Cited by 41 · see citing works
“also indicated that endometrial MSCs exhibit high tropism to endometriotic lesions, and a recent study further demonstrated that endometriotic MSCs, rather than differentiated cells from endometriotic lesions, can enter the vascular circulation, potentially through the CXCL12/CXCR4 axis, and lead to haematogenous diss…”
BackgroundApplication of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases
Ryu, J., Jeong, E.-J., Kim, J., Park, S. J., Ju, W. S., Kim, C., Kim, J., & Choo, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218366 · Cited by 38 · see citing works
Penariol, L. B. C., Thomé, C. H., Tozetti, P. A., Paier, C. R. K., Buono, F. D. O., Peronni, K. C., Orellana, M. D., Covas, D. T., de Moraes, M. E. A., Silva, W. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911515 · Cited by 34 · see citing works
“Since the stem cells have tropism for endometriotic lesions [88], we selected patients who had presented diagnostic imaging suggestive of endometrioma at the time of collection as evidence of active disease in the pelvic cavity.”
BackgroundWang, S., Shi, C., Cai, X., Wang, Y., Chen, X., Han, H., & Shen, H. (2021) · Mediators of Inflammation · doi:10.1155/2021/5573594 · Cited by 34 · see citing works
Sahraei, S. S., Asl, F. D., Kalhor, N., Sheykhhasan, M., Fazaeli, H., Moud, S. S., & Sheikholeslami, A. (2022) · BioMed Research International · doi:10.1155/2022/7053521 · Cited by 32 · see citing works
Sabeh, M. E., Afrin, S., Singh, B., Miyashita‐Ishiwata, M., & Borahay, M. A. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10075-w · Cited by 26 · see citing works
de Oliveira, R. Z., Buono, F. D. O., Cressoni, A. C. L., Penariol, L. B. C., Padovan, C. C., Tozetti, P. A., Poli‐Neto, O. B., Ferriani, R. A., Orellana, M. D., Silva, J. C. R. E., et al. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00860-y · Cited by 24 · see citing works
“The presence of endometriotic lesions in the cavity can influence stem cell tropism [25, 26].”
BackgroundPonandai‐Srinivasan, S., Andersson, K. L., Nistér, M., Saare, M., Hassan, H. A., Varghese, S. J., Peters, M., Salumets, A., Gemzell‐Danielsson, K., & Lalitkumar, P. G. (2018) · Human Reproduction · doi:10.1093/humrep/dey241 · Cited by 23 · see citing works
“Previous studies have shown a key role for stem cells/progenitors (SC) in aetiology of endometriosis (Cheng et al., 2017).”
BackgroundEndometriosis — insights into a multifaceted entity
Amălinei, C., Păvăleanu, I., Lozneanu, L., Balan, R. A., Giuşcă, S. E., & Căruntu, I.-D. (2018) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2018.0013 · Cited by 16 · see citing works
EndMT-derived mesenchymal stem cells: a new therapeutic target to atherosclerosis treatment
Zhang, X., Ren, Z., & Jiang, Z. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04544-8 · Cited by 16 · see citing works
Therapeutic restoration of female reproductive and endocrine dysfunction using stem cells
Liu, X., Li, J., Wang, W., Ren, X., & Hu, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121658 · Cited by 18 · see citing works
Biglari, N., Mehdizadeh, A., Mastanabad, M. V., Gharaeikhezri, M. H., Afrakoti, L. G. M. P., Pourbala, H., Yousefi, M., & Soltani‐Zangbar, M. S. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154541 · Cited by 15 · see citing works
Chen, K., Wang, H., Zhao, X., Wang, J., Jin, Q., Tong, X., & Zheng, S. (2024) · Reproductive Sciences · doi:10.1007/s43032-024-01458-2 · Cited by 15 · see citing works
de Jolinière, J. B., Major, A. L., Ayoubi, J. M., Cabry, R., Khomsi, F., Lesec, G., Frydman, R., & Féki, A. (2019) · Frontiers in Surgery · doi:10.3389/fsurg.2019.00027 · Cited by 14 · see citing works
“Overexpression of estrogen receptors (ER), receptor resistance to progesterone, and deregulation of NF-kappa activation leads to increased proliferation of endometrial cells, inflammation, and angiogenesis (35).”
BackgroundRahnama, M., Ghasemzadeh, N., Latifi, Z., Kheradmand, F., Koukia, F. A., Sharun, K., & Golchin, A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177726 · Cited by 13 · see citing works
Cheng, Y., Guo, Q., Cheng, Y., Wang, D., Sun, L., Liang, T., Wang, J., Wu, H., Peng, Z., & Zhang, G. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae079 · Cited by 14 · see citing works
“31 Adult stem are rare, undifferentiated cells found in mature tissues and organs.”
InfluentialGuan, X., Chen, P., Zhao, X., Hao, X., Chen, F., Ji, M., Wen, X., Lin, H., Ye, L., & Chen, H. (2019) · Stem Cell Research · doi:10.1016/j.scr.2019.101593 · Cited by 13 · see citing works
Khodayari, S., Khodayari, H., Ebrahimi‐Barough, S., Khanmohammadi, M., Islam, M. S., Vesovic, M., Goodarzi, A., Mahmoodzadeh, H., Nayernia, K., Aghdami, N., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.834754 · Cited by 14 · see citing works
Farahani, Z. K., Taherianfard, M., Naderi, M. M., & Ferrero, H. (2021) · Physiological Reports · doi:10.14814/phy2.15117 · Cited by 12 · see citing works
“It has a prevalence of 15%– 25%; however, it is seen in about 50% of the infertile women (Cheng et al., 2017; Foti et al., 2018; Zhang et al., 2017).”
BackgroundApplication progress of single-cell sequencing technology in mesenchymal stem cells research
Li, H., Wang, Y., Zhu, G., Ma, Q., Huang, S., Guo, G., & Zhu, F. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1336482 · Cited by 10 · see citing works
Cressoni, A. C. L., Penariol, L. B. C., Padovan, C. C., Orellana, M. D., Silva, J. C. R. E., Poli‐Neto, O. B., Ferriani, R. A., de Paz, C. C. P., & Meola, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065963 · Cited by 9 · see citing works
“Stem cells have a tropism for endometriotic lesions [73].”
BackgroundNon-invasive blood tests for earlier diagnosis and treatment of endometriosis
Oskouei, B. S., Asadi, Z., & Jahanban‐Esfahlan, R. (2025) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2025.104521 · Cited by 8 · see citing works
Non-gynaecological Applications of Menstrual-derived Stem Cells: A Systematic Review
Galea, C., Riva, N., & Calleja‐Agius, J. (2022) · Avicenna Journal of Medical Biotechnology · doi:10.18502/ajmb.v14i1.8166 · Cited by 8 · see citing works
Wang, D., Wu, X.-M., Chen, J.-S., Cai, Z.-G., An, J., Zhang, M., Li, Y., Li, F., Hou, R., & Liu, Y. (2022) · Conservation Physiology · doi:10.1093/conphys/coac004 · Cited by 8 · see citing works
“Moreover, eMSCs could generate endometrial stroma in xenograft assays (Masuda et al., 2010). eMSCs have been harvested and characterized from humans (Cheng et al., 2017; Queckborner et al., 2020), pigs (Miernik & Karasinski, 2012), heifers (Calle et al., 2019; de Moraes et al., 2016), horses…”
BackgroundHe, Y., Wang, J.-K., Jiang, X., Gao, J., Cheng, Y., Liang, T., Zhou, J. Y., Sun, L., & Zhang, G. (2022) · BMC Molecular and Cell Biology · doi:10.1186/s12860-022-00426-5 · Cited by 7 · see citing works
“Macroscopic observation and H&E staining were used to assess lesion formation [20].”
MethodMesenchymal stem cells: Guardians of women's health
Gao, G., Li, L., Li, C., Liu, D., Wang, Y., & Li, C. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.10.011 · Cited by 6 · see citing works
Sadiasa, A., Werkmeister, J. A., Gurung, S., & Gargett, C. E. (2025) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2025.2465826 · Cited by 4 · see citing works
Farahani, Z. K., Taherianfard, M., Naderi, M. M., & Ferrero, H. (2021) · Journal of Family & Reproductive Health · doi:10.18502/jfrh.v14i4.5210 · Cited by 4 · see citing works
“Pelvic pain, dyspareunia, and dysuria, dyschezia, as well as infertility, are the primary signs and symptoms of endometriosis (1-4).”
BackgroundHacimoto, S. Y. S., Cressoni, A. C. L., da Silva, L. E. C. M., Padovan, C. C., Ferriani, R. A., Silva, J. C. R. E., & Meola, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306657 · Cited by 5 · see citing works
“Since stem cells have tropism for endometriotic lesions [48], the patients selected for this group had an imaging diagnosis suggestive of endometrioma during sample collection as evidence of active disease in the pelvic cavity.”
Human Endometrial Regenerative Cells for Neurological Disorders: Hype or Hope?
Momeni, J., Naserzadeh, E., Sepehrinezhad, A., Ahmadabad, R. A., & Negah, S. S. (2024) · International Journal of Stem Cells · doi:10.15283/ijsc23091 · Cited by 3 · see citing works
Characteristic and Regenerative Potential of Human Endometrial Stem Cells and Progenitors
Ghamari, A., Daghigh, F., Mohebbi, A., Rahimi, Y., Shojaie, L., & Zolbin, M. M. (2021) · Springer eBooks · doi:10.1007/978-981-16-0301-3_3 · Cited by 2 · see citing works
Therapeutic application of mesenchymal stem cells in endometriosis
Varela-Pombo, C., López-Viñas, B., Tustain, S. Q., Maquieira, C. G., Mateos, J., Fafián‐Labora, J., & Arufe, M. C. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123851 · Cited by 2 · see citing works
Gogusev, J., Lepelletier, Y., Khattabi, L. E., Grigoroiu, M., & Validire, P. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00193-8 · Cited by 2 · see citing works
“For comparison, the revealed CD9, CD13, CD73, CD90, and CD105 cell markers in TH-EM1 cell line were also observed in both immortalized endometrial stromal cells and endometrial mesenchymal stem cells established from lesions and eutopic endometrium.(10,33,34) However, the coexpression of hematopoietic and embryonic ma…”
ResultGogusev, J., Lepelletier, Y., Khattabi, L. E., Grigoroiu, M., & Validire, P. (2019) · Reproductive Sciences · doi:10.1177/1933719119833475 · Cited by 1 · see citing works
Feasibility of serum-free culture in isolating endometriotic stem cells
Liu, S., Tian, X., Cui, H., Zhang, Q., & Hua, K. (2019) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog4921.2019
“The pathogenesis of endometriosis is yet not fully understood and the stem cell theory of endometriosis has obtained increasing focus with the rapid development in the stem cell research field [3, 4].”
BackgroundBal, M., Salunke, V., Pande, S., Sachdeva, G., & Das, D. K. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11216-3
- Authors
- Cheng, Y., Li, L., Wang, D., Guo, Q., He, Y., Liang, T., Sun, L., Wang, X., Cheng, Y., & Zhang, G.
- Affiliations
- Harbin Engineering University (CN)
- Harbin Medical University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Corresponding author
- Zhang, Guangmei
- ORCID
- Venue
- Stem Cells International
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-9
- ISSN
- 1687-966X (ISSN-L)
- 1687-9678
- PMC
- PMC5518492
- OpenAlex
- W2733985300
- Cited by
- 48
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 2
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cells International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- State Key Basic Research and Development Project of China (2012CB526700, YJSCX2015-23HYD, 81242092)
- Harbin Medical University (2012CB526700, YJSCX2015-23HYD, 81242092)
- National Natural Science Foundation of China (2012CB526700, YJSCX2015-23HYD, 81242092)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- endometrial mesenchymal stem cells, endometriosis, stem cell isolation, stem cell markers, Oct4, osteogenic differentiation, adipogenesis, chondrogenic differentiation, drug carriers, cell therapy, unexplained infertility
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