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Cited by 46Mitochondrial Function and PathologyPluripotent Stem Cells ResearchAutophagy in Disease and Therapy

Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells

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Woods, D. C.·2017·Stem Cells International
DOI 10.1155/2017/7068567PMC PMC5516713
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Abstract

Although traditionally viewed as the “powerhouse” of the cell, an accruing body of evidence in the rapidly growing field of mitochondrial biology supports additional roles of mitochondria as key participants in a multitude of cellular functions. While it has been well established that mitochondria in different tissues have distinctive ultrastructural features consistent with differential bioenergetic demands, recent and emerging technical advances in flow cytometry, imaging, and “-omics”-based bioinformatics have only just begun to explore the complex and divergent properties of mitochondria within tissues and cell types. Moreover, contemporary studies evaluating the role of mitochondria in pluripotent stem cells, cellular reprogramming, and differentiation point to a potential importance of mitochondrial subpopulations and heterogeneity in the field of stem cell biology. This review assesses the current literature regarding mitochondrial subpopulations within cell and tissue types and evaluates the current understanding of how mitochondrial diversity and heterogeneity might impact cell fate specification in pluripotent stem cells.

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  • Less dense cristae is an indicator of impaired mitochondrial activity.

    “less dense cristae, which is another indicator of impaired mitochondrial activity37,38”

    From Altered mitochondrial dynamics and function in APOE4-expressing astrocytes (2020) · cites this paper as [37]

    In §1, “Mitochondrial Structure and Diversity” (page not provided), the paper associates low cristae density with slow respiration and describes stem-cell mitochondria with few cristae as having limited oxidative capacity. That supports a link to lower mitochondrial activity, but the paper also presents sparse cristae as a normal feature of stem cells, not necessarily an indicator of impairment. (LLM, conf=0.84)

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  • APOE4 astrocytes exhibit less dense cristae.

    “and by less dense cristae, which is another indicator of impaired mitochondrial activity37,38 (Fig. 5d).”

    From Altered mitochondrial dynamics and function in APOE4-expressing astrocytes (2020) · cites this paper as [37]

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Authors
Woods, D. C.
Affiliations
Northeastern University (US)
Corresponding author
Woods, D. C.
ORCID
Woods, D. C.
Venue
Stem Cells International
Publisher
Wiley
Published
2017
Volume
2017
Pages
1-7
ISSN
  • 1687-966X (ISSN-L)
  • 1687-9678
DOI
10.1155/2017/7068567
PMC
PMC5516713
OpenAlex
W2726817246
Cited by
46
References
4
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 1
FWCI
0.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cells International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial heterogeneity, mitochondrial subpopulations, stem cells, pluripotent stem cells, cellular reprogramming, cell differentiation, cell fate specification, mitochondrial ultrastructure, mitochondrial bioenergetics, mitochondrial dynamics

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