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Cited by 21

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Optimization of the Time Window of Interest in Ovariectomized Imprinting Control Region Mice for Antiosteoporosis Research

Song, Lei, Bi, Ya-nan, Zhang, Pan-yang, Yuan, Xiao-mei, Liu, Ying, Zhang, Yue, Huang, Ju-yang, Zhou, Kun·2017·BioMed Research International
DOI 10.1155/2017/8417814PMC PMC5651096
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Abstract

This study was performed to determine the optimal window of time during which the properties of osteoporosis are obvious and to explore the best region of interest for microstructural evaluation in antiosteoporosis research in an ovariectomized mouse model by examining changes in micro-computed tomography parameters and serum indices. Ovariectomized mice and sham-operated mice were randomly divided into five groups. At the end of the 4th, 8th, 12th, 16th, and 20th weeks after ovariectomy, the microstructure of the proximal tibia and distal femur was scanned by micro-computed tomography and blood samples were collected to detect serum biochemical indicators including alkaline phosphatase, osteocalcin, N-terminal propeptide of type I procollagen (P1NP), and C-terminal telopeptide fragment of type I collagen (CTX1). The trabecular number and connectivity density decreased while the trabecular thickness and trabecular separation increased, indicating substantial changes in the trabecular microstructure of both the tibia and femur and significant changes in bone turnover after ovariectomy, as indicated by lower levels of serum alkaline phosphatase, osteocalcin, and P1NP and higher level of CTX1 in the ovariectomy than sham group. The proximal tibia from weeks 8 to 16 after ovariectomy was optimal for osteoporosis research in this model.

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Figures

Figure 1 Average body weight of mice during 20-week study period. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point, but no significant differences were observed.
Figure 1 Average body weight of mice during 20-week study period. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point, but no significant differences were observed.CC BY · PubMed Central
Figure 2 Tibial 3D images at different time points. Tibial 3D images in the sham and OVX groups were built and are presented in pairs at different time points.
Figure 2 Tibial 3D images at different time points. Tibial 3D images in the sham and OVX groups were built and are presented in pairs at different time points.CC BY · PubMed Central
Figure 3 Structural parameters of the tibia. The structural parameters of the trabecular bone of the tibia were measured with micro-CT. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point. ∗p < 0.05; ∗∗p < 0.01 versus sham. Tb.N∗, Tb.Th∗, and Tb.Sp∗ indicate that the algorithm was recommended by the software.
Figure 3 Structural parameters of the tibia. The structural parameters of the trabecular bone of the tibia were measured with micro-CT. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point. ∗p < 0.05; ∗∗p < 0.01 versus sham. Tb.N∗, Tb.Th∗, and Tb.Sp∗ indicate that the algorithm was recommended by the software.CC BY · PubMed Central
Figure 4 Changes in the tibial microstructure. The ratios (OVX/sham) of bone parameters measured by micro-CT were analyzed to observe the relative changes in each parameter. Tb.N∗, Tb.Th∗, and Tb.Sp∗ mean that the algorithm was recommended by the software.
Figure 4 Changes in the tibial microstructure. The ratios (OVX/sham) of bone parameters measured by micro-CT were analyzed to observe the relative changes in each parameter. Tb.N∗, Tb.Th∗, and Tb.Sp∗ mean that the algorithm was recommended by the software.CC BY · PubMed Central
Figure 5 Femoral 3D images at different time points. Femoral 3D images in the sham and OVX groups were built and are presented in pairs at different time points.
Figure 5 Femoral 3D images at different time points. Femoral 3D images in the sham and OVX groups were built and are presented in pairs at different time points.CC BY · PubMed Central
Figure 6 Structural parameters of the femur. The structural parameters of the trabecular bone of the femur were measured with micro-CT. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point. ∗p < 0.05; ∗∗p < 0.01 versus sham. Tb.N∗, Tb.Th∗, and Tb.Sp∗ mean that the algorithm was recommended by the software.
Figure 6 Structural parameters of the femur. The structural parameters of the trabecular bone of the femur were measured with micro-CT. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point. ∗p < 0.05; ∗∗p < 0.01 versus sham. Tb.N∗, Tb.Th∗, and Tb.Sp∗ mean that the algorithm was recommended by the software.CC BY · PubMed Central
Figure 7 Changes in the microstructure of the femur. The ratios (OVX/sham) of bone parameters measured by micro-CT were analyzed to observe the relative changes in each parameter. Tb.N∗, Tb.Th∗, and Tb.Sp∗ mean that the algorithm was recommended by the software.
Figure 7 Changes in the microstructure of the femur. The ratios (OVX/sham) of bone parameters measured by micro-CT were analyzed to observe the relative changes in each parameter. Tb.N∗, Tb.Th∗, and Tb.Sp∗ mean that the algorithm was recommended by the software.CC BY · PubMed Central
Figure 8 Serum levels of OC, ALP, P1NP, and CTX1. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point. ∗p < 0.05; ∗∗p < 0.01 versus sham.
Figure 8 Serum levels of OC, ALP, P1NP, and CTX1. Sham, sham-operated group (control group); OVX, ovariectomized group (experimental group). The OVX and sham groups were compared at each time point. ∗p < 0.05; ∗∗p < 0.01 versus sham.CC BY · PubMed Central
Figure 9 Ratios (OVX/sham) of OC, ALP, P1NP, and CTX1. To observe the relative change of the parameters, the ratio (OVX/sham) derived from bone turnover markers was presented.
Figure 9 Ratios (OVX/sham) of OC, ALP, P1NP, and CTX1. To observe the relative change of the parameters, the ratio (OVX/sham) derived from bone turnover markers was presented.CC BY · PubMed Central

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Citations

Cites

Research works printed but not linked: 27

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Cited by

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Metadata

Authors
Song, L., Bi, Y.-N., Zhang, P.-Y., Yuan, X.-M., Liu, Y., Zhang, Y., Huang, J.-Y., & Zhou, K.
Venue
BioMed Research International
Publisher
Wiley
Published
2017
Volume
2017
Pages
1-10
ISSN
  • 2314-6133
  • 2314-6141
DOI
10.1155/2017/8417814
PMC
PMC5651096
Cited by
21
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)
Funders
  • National Natural Science Foundation of China (81673826, 2011ZX09201-201-21)
  • National Science and Technology Major Projects (81673826, 2011ZX09201-201-21)

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