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Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview
Abstract
Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo .
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Metadata
- Authors
- Rowdhwal, S. S. S., & Chen, J.
- Affiliations
- Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2018
- Volume
- 2018
- Pages
- 1-10
- ISSN
- 2314-6133
- 2314-6141
- PMC
- PMC5842715
- Cited by
- 456
- References
- 1
- Language
- en
- Funders
- National Natural Science Foundation of China (81360098, 81660255, 81200433, 0153BCB23032)
- Young Scientist Training Project of Jiangxi Province (81360098, 81660255, 81200433, 0153BCB23032)
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