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Cited by 62Vestibular and auditory disordersHearing, Cochlea, Tinnitus, GeneticsSystemic Lupus Erythematosus Research

The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss

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Li, Guangfei, You, Dan, Ma, Jiaoyao, Li, Wen, Li, Huawei, Sun, Shan·2018·Neural Plasticity
DOI 10.1155/2018/7691473PMC PMC6020465
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Abstract

Sudden sensorineural hearing loss (SSHL) is a clinically common acute symptom in otolaryngology. Although the incidence of SSHL has increased around the world in recent years, the etiology of the disease is still unclear. It has been reported that infections, ototoxic drugs, membrane labyrinth rupture, carcinomas, circulatory system diseases, autoimmune diseases, brain lesions, mental diseases, congenital or inherited diseases, and so on, are all risk factors for SSHL. Here, we discuss the autoimmune mechanisms behind SSHL, which might be induced by type II–IV allergic reactions. We also introduce the main immunosuppressive medications that have been used to treat SSHL, which will help us to identify potential targets for immune therapy.

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  • Although some hypotheses have been proposed regarding the causes of SSNHL, such as vascular insufficiency, virus infection, and immune dysfunction, none of these can explain SSNHL in all patients.

    “Although some hypotheses have been proposed regarding the causes of SSNHL, such as vascular insufficiency, 22 virus infection, 28 and immune dysfunction, 29 none of these can explain SSNHL in all patients.”

    From Recurrent sudden sensorineural hearing loss—A literature review (2022) · cites this paper as [29]

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  91. [93]Bilate A. M. Lafaille J. J. Induced CD4+Foxp3+ regulatory T cells in immune tolerance Annual Review of Immunology 2012 30 1 733 758 10.1146/annurev-immunol-020711-075043 2-s2.0-84859390119 22224762 · DOI · Paper page

Cited by

Sorted by citations

Authors
Li, G., You, D., Ma, J., Li, W., Li, H., & Sun, S.
Affiliations
Shanghai Medical College of Fudan University (CN)
Corresponding author
  • Li, Huawei
  • Sun, Shan
ORCID
Venue
Neural Plasticity
Publisher
Wiley
Published
2018-06-13
Volume
2018
Pages
1-9
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2018/7691473
PMC
PMC6020465
OpenAlex
W2808645156
Cited by
62
References
0
Citations by year
2026: 6 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 9 · 2019: 5
FWCI
0.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Shanghai Pujiang Talents Plan (18PJ1401700, 81620108005, 81570913, 2016YFC0905200, 2017YFA0103900)
  • National Natural Science Foundation of China (18PJ1401700, 81620108005, 81570913, 2016YFC0905200, 2017YFA0103900)
  • National Key R&D Program of China (18PJ1401700, 81620108005, 81570913, 2016YFC0905200, 2017YFA0103900)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords
sudden sensorineural hearing loss, autoimmunity, autoimmune mechanisms, delayed-type hypersensitivity, immunosuppressive therapy, risk factors, ototoxic drugs
MeSH terms
Hearing Loss, Sudden, Humans, Immunosuppressive Agents, Autoimmunity, Treatment Outcome

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