The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Role of Histamine in Modulating the Immune Response and Inflammation
Open accessAbstract
Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chemically induced mouse models of intestinal inflammation
Wirtz, S., Neufert, C., Weigmann, B., & Neurath, M. F. (2007) · Nature Protocols · doi:10.1038/nprot.2007.41 · Cited by 1,567
Microbiome-wide association studies link dynamic microbial consortia to disease
Gilbert, J. A., Quinn, R. A., Debelius, J., Xu, Z. Z., Morton, J., Garg, N., Jansson, J. K., Dorrestein, P. C., & Knight, R. (2016) · Nature · doi:10.1038/nature18850 · Cited by 718
Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors
Jutel, M., Watanabe, T., Klunker, S., Akdis, M., Thomet, O. A. R., Malolepszy, J., Zak-Nejmark, T., Koga, R., Kobayashi, T., Blaser, K., et al. (2001) · Nature · doi:10.1038/35096564 · Cited by 587
Human Microbiome in Health and Disease
Pflughoeft, K. J., & Versalovic, J. (2012) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132421 · Cited by 529
Thomas, C. M., Hong, T., van Pijkeren, J. P., Hemarajata, P., Trinh, D. V., Hu, W., Britton, R. A., Kalkum, M., & Versalovic, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031951 · Cited by 491
Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells
Hofstra, C. L., Desai, P. J., Thurmond, R. L., & Fung-Leung, W.-P. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046581 · Cited by 469
Mazzoni, A., Young, H. A., Spitzer, J. H., Visintin, A., & Segal, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13930 · Cited by 354
Regulation of the immune response and inflammation by histamine and histamine receptors
O’Mahony, L., Akdis, M., & Akdis, C. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.051 · Cited by 313
Dunford, P. J., Williams, K. N., Desai, P. J., Karlsson, L., McQueen, D., & Thurmond, R. L. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.08.034 · Cited by 308
Dunford, P. J., O’Donnell, N., Riley, J. P., Williams, K. N., Karlsson, L., & Thurmond, R. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.7062 · Cited by 290
Cited by
Aslam, H., Trakman, G., Dissanayake, T., Todd, E., Harrison, P., Alby, C., Jabeen, T., Gamage, E., Travica, N., Marshall, S., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07428-9 · Cited by 30
Velho, R. V., Freitag, J. H., Brueckner, A. M., Thalmeier, L., Pohl, J., & Mechsner, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010212 · Cited by 7
Calvanese, C. M., Valentino, V., De Prisco, A., Allesina, S., Amoruso, A., Deidda, F., Visciglia, A., Ercolini, D., Pane, M., & De Filippis, F. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06107-2 · Cited by 2
“Beyond direct translocation, indirect interactions involv - ing metabolites or immunoglobulin production, as well as the ability of gut microbes of metabolizing estrogens may be also implicated in the gut-vagina communication [52, 57–59].”
Metadata
- Authors
- Branco, A. C. C. C., Yoshikawa, F. S. Y., Pietrobon, A. J., & Sato, M. N.
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2018-08-27
- Volume
- 2018
- Pages
- 1-10
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- OpenAlex
- W2889432911
- Cited by
- 388
- References
- 75
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Role of Histamine in Modulating the Immune Response and Inflammation. https://app.cochat.ai/papers/10.1155/2018/9524075
- The paper
- Branco, A. C. C. C., Yoshikawa, F. S. Y., Pietrobon, A. J., & Sato, M. N. (2018). Role of Histamine in Modulating the Immune Response and Inflammation. Mediators of Inflammation. https://doi.org/10.1155/2018/9524075
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
