Cited by 193Mesenchymal stem cell researchNeonatal Respiratory Health ResearchTransplantation: Methods and Outcomes

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Mesenchymal Stem Cell-Based Therapy of Inflammatory Lung Diseases: Current Understanding and Future Perspectives

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Harrell, C. Randall, Sadikot, Ruxana, Pascual, Jose, Fellabaum, Crissy, Jankovic, Marina Gazdic, Jovicic, Nemanja, Djonov, Valentin, Arsenijevic, Nebojsa, Volarevic, Vladislav·2019·Stem Cells International

DOI 10.1155/2019/4236973PMC PMC6525794

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Abstract

During acute or chronic lung injury, inappropriate immune response and/or aberrant repair process causes irreversible damage in lung tissue and most usually results in the development of fibrosis followed by decline in lung function. Inhaled corticosteroids and other anti-inflammatory drugs are very effective in patients with inflammatory lung disorders, but their long-term use is associated with severe side effects. Accordingly, new therapeutic agents that will attenuate ongoing inflammation and, at the same time, promote regeneration of injured alveolar epithelial cells are urgently needed. Mesenchymal stem cells (MSCs) are able to modulate proliferation, activation, and effector function of all immune cells that play an important role in the pathogenesis of acute and chronic inflammatory lung diseases. In addition to the suppression of lung-infiltrated immune cells, MSCs have potential to differentiate into alveolar epithelial cells in vitro and, accordingly, represent new players in cell-based therapy of inflammatory lung disorders. In this review article, we described molecular mechanisms involved in MSC-based therapy of acute and chronic pulmonary diseases and emphasized current knowledge and future perspectives related to the therapeutic application of MSCs in patients suffering from acute respiratory distress syndrome, pneumonia, asthma, chronic obstructive pulmonary diseases, and idiopathic pulmonary fibrosis.

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RETRACTED: Ischemia postconditioning and mesenchymal stem cells engraftment synergistically attenuate ischemia reperfusion-induced lung injury in rats
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Authors: Harrell, C. R., Sadikot, R., Pascual, J., Fellabaum, C., Jankovic, M. G., Jovicic, N., Djonov, V., Arsenijevic, N., & Volarevic, V.
Affiliations: Regenerative Processing Plant, LLC, 34176 UD Highway 19 N Palm Harbor, Palm Harbor, Florida, USA
Emory University (US)
Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, Serbia
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia
University of Bern (CH)
West Pasco Pulmonary Associates, 7545 Medical Dr, Hudson, Florida, USA
Institute of Anatomy, University of Bern, 2 Baltzerstrasse, Switzerland
ORCID: Harrell, C. Randall
Sadikot, Ruxana
Fellabaum, Crissy
Jovicic, Nemanja
Djonov, Valentin
Volarevic, Vladislav
Venue: Stem Cells International
Publisher: Wiley
Published: 2019-05-02
Volume: 2019
Pages: 1-14
ISSN: 1687-966X (ISSN-L)
1687-9678
DOI: 10.1155/2019/4236973
PMC: PMC6525794
OpenAlex: W2943233832
Cited by: 193
References: 126
Citations by year: 2026: 3 · 2025: 14 · 2024: 18 · 2023: 22 · 2022: 37 · 2021: 58 · 2020: 34 · 2019: 7
FWCI: 4.14
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Stem Cells International (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
BORIS (University Library Bern) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Open Access CRIS of the University of Bern
Funders: University of Kragujevac (MP01/18, ON175103, ON175069, 16C197)
Serbian Ministry of Science (MP01/18, ON175103, ON175069, 16C197)
Novartis Foundation (MP01/18, ON175103, ON175069, 16C197)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords: mesenchymal stem cells, cell therapy, inflammatory lung disease, pulmonary fibrosis, acute respiratory distress syndrome, pneumonia, asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, immunomodulation, lung injury

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