Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

Cites (313)

Items 201–313 of 313

1. Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL‐2 knockdown in human malignant neuroblastoma SK‐N‐DZ cells
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2. PCDH17 gene promoter demethylation and cell cycle arrest by genistein in gastric cancer.
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3. Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer.
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4. Sensitization of the apoptotic effect of gamma-irradiation in genistein-pretreated CaSki cervical cancer cells.
   Jang‐In Shin, Jung‐Hyun Shim, Ki Hong Kim · 2008 · PubMed
5. Immunohistochemical expression of TGF beta (TGF-β), TGF beta receptor 1 (TGFBR1), and Ki67 in intestinal variant of gastric adenocarcinomas.
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6. The Burden of the Serious and Difficult-to-Treat Infections and a New Antibiotic Available: Cefiderocol
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7. Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial
   Kenneth F. Adams, Paul D. Lampe, Katherine M. Newton · 2005 · American Journal of Clinical Nutrition
8. Genistein reduces the noxious effects of in utero bisphenol A exposure on the rat prostate gland at weaning and in adulthood
   Bruna Dias Bernardo, Joyce Zalotti Brandt, Tony Fernando Grassi, Lívia Teresa Ribeiro da Silveira, Wellerson Rodrigo Scarano, Luı́s Fernando Barbisan · 2015 · Food and Chemical Toxicology
9. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells
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10. Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification
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11. Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial
    Kenneth F. Adams, Paul D. Lampe, Katherine M. Newton · 2005 · American Journal of Clinical Nutrition
12. Modulation of Oxidative Stress by 17 β-Estradiol and Genistein in Human Hepatic Cell Lines In Vitro
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13. Genistein represses PEPCK‐C expression in an insulin‐independent manner in HepG2 cells and in alloxan‐induced diabetic mice
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14. A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals
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15. Genistein induces apoptosis by stabilizing intracellular p53 protein through an APE1-mediated pathway
    Jianwu Zhu, Chong Zhang, Yi Qing · 2015 · Free Radical Biology and Medicine
16. Soy and the soy isoflavone genistein promote adipose tissue development in male mice on a low-fat diet
    Isabella Zanella, Eleonora Marrazzo, Giorgio Biasiotto, Marialetizia Penza, Annalisa Romani, Pamela Vignolini, Luigi Caimi, Diego Di Lorenzo · 2014 · European Journal of Nutrition
17. 7-difluoromethoxyl-5,4′-di-n-octyl genistein inhibits ovarian cancer stem cell characteristics through the downregulation of FOXM1
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18. Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women
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20. Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition
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21. Genistein affects the morphology of pituitary ACTH cells and decreases circulating levels of ACTH and corticosterone in middle-aged male rats
    VLADIMIR Z AJDŽANOVI, BRANKA T ŠOŠI-JURJEVI, Branko Filipovi · 2009 · Biological Research
22. The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase
    Tzu‐Chin Wu, Yi‐Chin Lin, Hsiao‐Ling Chen, Pei-Ru Huang, Shangyu Liu, Shu-Lan Yeh · 2016 · Toxicology and Applied Pharmacology
23. 7-Difluoromethoxyl-5,4′-di-n-octyl genistein inhibits the stem-like characteristics of gastric cancer stem-like cells and reverses the phenotype of epithelial-mesenchymal transition in gastric cancer cells
    Xiaozheng Cao, Kaiqun Ren, Zhenwei Song · 2016 · Oncology Reports
24. Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway
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25. Antigenotoxic effect of genistein against 7,12-dimethylbenz[a]anthracene induced genotoxicity in bone marrow cells of female wistar rats
    Pachaiappan Pugalendhi, Shanmugam Manoharan, Panjamurthy Kuppusamy · 2009 · Pharmacological Reports
26. The effects of genistein and daidzein on cell proliferation kinetics in HT29 colon cancer cells: the expression of CTNNBIP1 (β-catenin), APC (adenomatous polyposis coli) and BIRC5 (survivin)
    Sandra Regina Lepri, Leonardo Campos Zanelatto, Patricia Benites Goncalves da Silva · 2014 · Human Cell
27. C/EBPβ promotes angiogenesis through secretion of IL‐6, which is inhibited by genistein, in EGFRvIII‐positive glioblastoma
    Xujie Liu, Kaiyu Liu, Jiazhen Qin, Limin Hao, Xiaoxia Li, Yinan Liu, Xiaoyan Zhang, Xiuxiu Liu, Peng Li, Shuo Han et al. · 2014 · International Journal of Cancer
28. IGF-I receptor signaling pathway is involved in the neuroprotective effect of genistein in the neuroblastoma SK-N-SH cells
    Quan‐Gui Gao, Junxia Xie, Man‐Sau Wong · 2011 · European Journal of Pharmacology
29. Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1
    Tzu‐Chin Wu, Ying-Chihi Yang, Pei-Ru Huang, Yu-Der Wen, Shu-Lan Yeh · 2012 · Toxicology and Applied Pharmacology
30. Effect of the Isoflavone Genistein on Tumor Size, Metastasis Potential and Melanization in a B16 Mouse Model of Murine Melanoma
    Corina Danciu, Florin Borcan, Florina Maria Bojin, István Zupkó, Cristina Adriana Dehelean · 2013 · Natural Product Communications
31. Genistein treatment duration effects biomarkers of cell motility in human prostate
    Hu Zhang, Ryan R. Gordon, Wenqi Li et al. · 2019 · PLoS ONE
32. Thinking Outside the Ischemia Box: Advancements in the Use of Multiple Sclerosis Drugs in Ischemic Stroke
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33. Inhibitory effect of genistein on PLC/PRF5 hepatocellular carcinoma cell line
    Mehdi Nikbakht Dastjerdi, Fraidoon Kavoosi, Ali Valiani, Ebrahim Esfandiari, Masumeh Sanaei, Saeed Sobhanian, Mazdak Ganjalıkhani-Hakemi, Maryam Mobarakian · 2015 · International Journal of Preventive Medicine
34. Orally Administered Isoflavones Are Present as Glucuronides in the Human Prostate
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35. Antiangiogenic and Toxic Effects of Genistein, Usnic Acid, and Their Copper Complexes in Zebrafish Embryos at Different Developmental Stages
    Heidrun Draut, Tobias Rehm, Gerrit Begemann, Rainer Schobert · 2016 · Chemistry & Biodiversity
36. In vitro investigation of antioxidant, anti‐Inflammatory, and antiplatelet adhesion properties of genistein‐modified poly(ethersulfone)/poly(vinylpyrrolidone) hemodialysis membranes
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37. Effect of genistein administration on the recovery of spermatogenesis in the busulfan-treated rat testis
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38. Genistein-induced apoptosis is mediated by endoplasmic reticulum stress in cervical cancer cells.
    Yang Ym, Yi Yang, Dai Ww · 2016 · PubMed
39. Equol producer status, salivary estradiol profile and urinary excretion of isoflavones in Irish Caucasian women, following ingestion of soymilk
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40. Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures
    Brante P. Sampey, Terrence D. Lewis, Claire Barbier, Liza Makowski, David G. Kaufman · 2011 · Experimental and Molecular Pathology
41. Soybean isoflavones attenuate the expression of genes related to endometrial cancer risk
    Adriana Aparecida Ferraz Carbonel, Michele Longoni Calió, Miriam Aparecida dos Santos · 2014 · Climacteric
42. Genistein Reinforces the Inhibitory Effect of Cisplatin on Liver Cancer Recurrence and Metastasis after Curative Hepatectomy
    Peng Chen, Mingdao Hu, Xiaofan Deng · 2013 · Asian Pacific Journal of Cancer Prevention
43. In vitro exposure to quercetin and genistein alters lipid peroxides and prevents the loss of glutathione in human progenitor mononuclear (U937) cells
    William Yaw Boadi, Peter Abeta Iyere, Samuel Evans Adunyah · 2005 · Journal of Applied Toxicology
44. Potential therapeutic mechanism of genistein in breast cancer involves inhibition of cell cycle regulation
    Ling Zhang, Bo Yang, Ke Zhou · 2014 · Molecular Medicine Reports
45. Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells
    Chandler Schexnayder, Robert E. Stratford · 2015 · International Journal of Environmental Research and Public Health
46. A Biotransformation Process for Production of Genistein from Sophoricoside by a Strain of Rhizopus oryza
    Jianfeng Mei, Xiang Chen, Jianghua Liu · 2019 · Scientific Reports
47. Inhibition of proliferation and induction of G1-phase cell-cycle arrest by dFMGEN, a novel genistein derivative, in lung carcinoma A549 cells
    Bo Peng, Jianguo Cao, Sisi Yi · 2012 · Drug and Chemical Toxicology
48. The effects of genistein on transforming growth factor-β1-induced invasion and metastasis in human pancreatic cancer cell line Panc-1 in vitro.
    Lei Han, Hongwei Zhang, Wenping Zhou · 2012 · PubMed
49. Germinated and Ungerminated Seeds Extract from Two Lupinus Species: Biological Compounds Characterization and In Vitro and In Vivo Evaluations
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50. Additivity, antagonism, and synergy in arsenic trioxide-induced growth inhibition of C6 glioma cells: Effects of genistein, quercetin and buthionine-sulfoximine
    Ellen Klauser, Michael Gülden, Edmund Maser · 2014 · Food and Chemical Toxicology
51. 7-difluoromethoxyl-5,4’-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1
    Honglin Xiang · 2012 · World Journal of Gastroenterology
52. H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells
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53. Glycone-rich Soy Isoflavone Extracts Promote Estrogen Receptor Positive Breast Cancer Cell Growth
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54. Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity
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55. Isoflavones in soy flour diet have different effects on whole‐genome expression patterns than purified isoflavone mix in human MCF‐7 breast tumors in ovariectomized athymic nude mice
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56. Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training
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57. Metabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective
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58. Estrogen-mimicking isoflavone genistein prevents bone loss in a rat model of obstructive sleep apnea-hypopnea syndrome.
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59. Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitro
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60. Effect of quercetin, genistein and kaempferol on glutathione and glutathione-redox cycle enzymes in 3T3-L1 preadipocytes
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61. Colorectal Cancer and Inflammatory Bowel Disease
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62. Novel effects of phytoestrogenic soy isoflavones on serum calcium and chloride in premenopausal women: A 2-year double-blind, randomized, placebo-controlled study
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63. Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells
    Yinan K. Wei, Irene Gamra, Andrew Davenport · 2015 · Journal of Environmental Pathology Toxicology and Oncology
64. Effect of genistein on steroidogenic response of granulosa cell populations from porcine preovulatory follicles.
    Anna Nynca, Renata E. Ciereszko · 2006 · PubMed
65. In vitro‐in silico‐based analysis of the dose‐dependentin vivooestrogenicity of the soy phytoestrogen genistein in humans
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66. Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts
    Surajit Karmakar, Subhasree Roy Choudhury, Naren Lal Banik, Swapan K. Ray · 2009 · Neuroscience
67. Novel Approach for Evaluation of Estrogenic and Anti‐Estrogenic Activities of Genistein and Daidzein using B16 Melanoma Cells and Dendricity Assay
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68. ATRA and Genistein synergistically inhibit the metastatic potential of human lung adenocarcinoma cells.
    Ji Cheng, Jun Qi, Xuetao Li · 2015 · PubMed
69. The Effects of Phytoestrogen Genistein on Steroidogenesis and Estrogen Receptor Expression in Porcine Granulosa Cells of Large Follicles
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70. Genistein Suppresses Spontaneous Oviduct Tumorigenesis in Quail
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71. Genistein Enhances the Cisplatin‐Induced Inhibition of Cell Growth and Apoptosis in Human Malignant Melanoma Cells
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72. Soya and isoflavone intakes associated with reduced risk of oesophageal cancer in north-west China
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73. Genistein ameliorates parathyroid hormone-induced epithelial-to-mesenchymal transition and inhibits expression of connective tissue growth factor in human renal proximal tubular cells
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74. Transcripional activity of genes encoding MMPs and TIMPs in breast cancer cells treated by genistein and in normal cancer-associated fibroblasts--in vitro studies.
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75. The combined effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phytoestrogen genistein on steroid hormone secretion, AhR and ERβ expression and the incidence of apoptosis in granulosa cells of medium porcine follicles
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76. Visfatin correlates with hot flashes in postmenopausal women with metabolic syndrome: effects of genistein
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77. Genistein Selectively Inhibits Estrogen-Induced Cell Proliferation and Other Responses to Hormone Stimulation in the Prepubertal Rat Uterus
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78. Effects of genistein on insulin pathway-related genes in mouse differentiated myoblast C2C12 cell line: evidence for two independent modes of action
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79. Dietary Genistein Rescues Reduced Basal Chloride Secretion in Diabetic Jejunum via Sex-Dependent Mechanisms
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80. A Bivalent Role of Genistein in Sprouting Angiogenesis
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81. Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells
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82. Reduction of leptin secretion by soy isoflavonoids in murine adipocytes in vitro
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83. Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation
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84. The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
    Bidur Parajuli, So‐Jin Shin, Sang‐Hoon Kwon · 2013 · Journal of Korean Medical Science
85. Biomarkers of Dietary Exposure Are Associated with Lower Risk of Breast Fibroadenomas in Chinese Women ,
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86. Isoflavone Genistein Modulates the Protein Expression of Toll-like Receptors in Cancerous Human Endometrial Cells.
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87. Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats
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88. Effects of Glucose on Cell Viability and Antioxidant and Anti-inflammatory Properties of Phytochemicals and Phytochemically Modified Membranes
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89. A novel approach regarding the anti‑aging of facial skin through collagen reorganization
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90. Effects of a phyto complex on well‐being of climacteric women
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91. Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms.
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92. Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells
    Nishant Mohan, Surajit Karmakar, Subhasree Roy Choudhury · 2009 · Brain Research
93. Genistein inhibits osteolytic bone metastasis and enhances bone mineral in nude mice
    Yanyan Zhang, Guoying Zhu, Shuzhu Gu · 2010 · Environmental Toxicology and Pharmacology
94. Effects of High-Order Interactions among IGFBP-3 Genetic Polymorphisms, Body Mass Index and Soy Isoflavone Intake on Breast Cancer Susceptibility
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95. The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism
    María Pérez‐Alonso, Laisa-Socorro Briongos, Marta Ruiz‐Mambrilla · 2017 · Lifestyle Genomics
96. Effect of the genistein metabolite on leptin secretion in murine adipocytes in vitro
    Toshio Niwa, Shin‐ichiro Yokoyama, Toshihiko Osawa · 2012 · Food Chemistry
97. Combination of Genistein and Cisplatin with Two Designed Monofunctional Platinum Agents in Human Ovarian Tumour Models.
    Laila Arzuman, Philip James Beale, Nick Proschogo · 2015 · PubMed
98. Genistein inhibits estradiol- and environmental endocrine disruptor-induced growth effects on neuroblastoma cells in vitro
    Jicui Zheng, Hui Li, Haitao Zhu · 2013 · Oncology Letters
99. Dietary Genistein Influences Number of Acetylcholine Receptors in Female Diabetic Jejunum
    Sydney Schacht, Faisal Masood, Shawn Catmull · 2017 · Journal of Diabetes Research
100. Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells
     Yitong Liu, Michael F. Santillo, Thomas J. Flynn · 2014 · In Vitro Cellular & Developmental Biology - Animal
101. Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4′7-O-dioleate in monkeys
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102. [Antimetastatic effects of genistein on salivary adenoid cystic carcinoma in vivo].
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104. Effect of cisplatin treatment on the urinary excretion of guanidinoacetic acid, creatinine and creatine in patients with urinary tract neoplasm, and on superoxide generation in human neutrophils.
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107. [Effects of genistein on the expressions of cell cycle proteins in salivary adenoid cystic carcinoma cell line SACC-83].
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108. [Effects of Genistein on the proliferation and expression of survivin in salivary adenoid cystic carcinoma cell line SACC-83].
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109. [Effects of genistein on apoptosis in HCT-116 human colon cancer cells and its mechanism].
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111. Two Case Reports on the Use of Genistein Combined Polysaccharide (GCP) Against Bladder Cancer Recurrence
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112. [Experimental studies of genistein on the proliferation and apoptosis of human prolactinoma cells cultured in vitro].
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113. IMPACT OF GENISTEIN AND PHYTIC ACID ON THE VIABILITY AND PROLIFERATION ACTIVITY OF NASAL POLYPS' CELLS IN AN IN VITRO MODEL.
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