The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Acyclovir Suppression to Prevent Recurrent Genital Herpesat Delivery
Open accessAbstract
OBJECTIVE: To determine if suppressive acyclovir near term decreased the frequency of clinical recurrences at delivery in women with recurrent genital herpes simplex virus (HSV) infection. METHODS: We conducted a prospective, double-blind, randomized trial in 234 women with recurrent genital herpes. Women with genital infection of any frequency were enrolled. Patients received either suppressive oral acyclovir 400 mg three times daily or an identical placebo after 36 weeks' gestation. Clinical lesions were identified, and HSV cultures were obtained at delivery. The frequencies of clinical and subclinical HSV recurrences at delivery were evaluated. RESULTS: Six percent of patients treated with acyclovir, and 14% of patients treated with placebo had clinical HSV at delivery (p = 0.046). No patients in the acyclovir group had positive HSV cultures, compared with 6% of placebo-treated patients (p = 0.029). There was no significant difference in subclinical HSV shedding in the acyclovir group (0%) compared with the placebo-treated group (3%) (p = 0.102). CONCLUSIONS: Suppressive acyclovir therapy significantly decreased the incidence of clinical genital herpes and the overall incidence of HSV excretion at delivery in patients with previous herpes infection.
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Suppressive acyclovir treatment starting at 36 weeks' gestation reduces the frequency of cesarean delivery among women who have recurrent genital herpes by diminishing the frequency of recurrences at term.
“Suppressive acyclovir treatment starting at 36 weeks’ gestation reduces the frequency of cesarean delivery among women who have recurrent genital herpes by diminishing the frequency of recurrences at term (521–523).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [523]
The Abstract reports that acyclovir given after 36 weeks reduced clinical herpes recurrences at delivery in women with recurrent genital herpes (6% versus 14%). The Results and Discussion say the lower frequency of cesarean delivery was not statistically significant, so the paper does not establish the claimed reduction in cesarean delivery. (LLM, conf=0.88)
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Cites
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Research works printed but not linked: 1
- Randolph AG, Washington AE, Prober CG. Cesarean delivery for women presenting with genital herpes lesions. J Am Med Assoc 1993;270: 77-82
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Metadata
- Authors
- Scott, L. L., Hollier, L. M., McIntire, D., Sanchez, P. J., Jackson, G. L., & Wendel, G. D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Scott, L. L.
- ORCID
- McIntire, D.
- Venue
- Infectious Diseases in Obstetrics and Gynecology
- Publisher
- Wiley
- Published
- 2001-11-30
- Volume
- 10
- Issue
- 2
- Pages
- 71-77
- ISSN
- 1064-7449 (ISSN-L)
- OpenAlex
- W2081558402
- Cited by
- 86
- References
- 26
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 1 · 2014: 7 · 2013: 4
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Infectious Diseases in Obstetrics and Gynecology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- acyclovir, suppressive antiviral therapy, recurrent genital herpes, herpes simplex virus, pregnancy, near-term pregnancy
- MeSH terms
- Acyclovir, Cesarean Section, Double-Blind Method, Female, Gestational Age, Herpes Genitalis, Humans, Infant, Newborn, Male, Placebos, Pregnancy, Prospective Studies, Recurrence, Virus Shedding, Simplexvirus, Infectious Disease Transmission, Vertical, Delivery, Obstetric
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